Boosting the catalytic performance of zinc linked amino acid complex as an eco‐friendly for synthesis of novel pyrimidines in aqueous medium

Ahmed, Eman A.; Soliman, Ahmed M.; Ali, Ali M.; El‐Remaily, Mahmoud Abd El Aleem Ali Ali

doi:10.1002/aoc.6197

Cited by 33 publications

(16 citation statements)

References 42 publications

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“…Other examples of one-pot chalcone derivatizations are those reported by Ahmed et al , which were aimed at synthesizing novel pyrimidine-based compounds. They developed a one-pot procedure where ketones and aldehydes were allowed to react to form the intermediate chalcone, then the properly functionalized guanidine was added to finalize the one-pot reaction, catalyzed in water media by green bio-organic Zn ( l -proline) 2 catalyst complex ( Ahmed et al, 2021 ). Khalili and colleagues proposed graphene oxide (GO) as a catalyst for the sequential formation of chalcone and derivatization thereof by aza-Michael addition of the desired amines to form β-amino ketones ( Khalili et al, 2020 ).…”

Section: Tools and Strategies For Improving The Efficiency Of Chalcon...mentioning

confidence: 99%

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Marotta

Rossi²,

Ibba³

et al. 2022

Front. Chem.

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The sustainable use of resources is essential in all production areas, including pharmaceuticals. However, the aspect of sustainability needs to be taken into consideration not only in the production phase, but during the whole medicinal chemistry drug discovery trajectory. The continuous progress in the fields of green chemistry and the use of artificial intelligence are contributing to the speed and effectiveness of a more sustainable drug discovery pipeline. In this light, here we review the most recent sustainable and green synthetic approaches used for the preparation and derivatization of chalcones, an important class of privileged structures and building blocks used for the preparation of new biologically active compounds with a broad spectrum of potential therapeutic applications. The literature here reported has been retrieved from the SciFinder database using the term “chalcone” as a keyword and filtering the results applying the concept: “green chemistry”, and from the Reaxys database using the keywords “chalcone” and “green”. For both databases the time-frame was 2017–2022. References were manually selected based on relevance.

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Section: Tools and Strategies For Improving The Efficiency Of Chalcon...mentioning

confidence: 99%

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Marotta

Rossi²,

Ibba³

et al. 2022

Front. Chem.

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“…We have been working on the development of novel tools and methodology for bioactive molecules synthesized utilizing green methodologies for the past few years. − …”

Section: Introductionmentioning

confidence: 99%

Efficient and Recoverable Bio-Organic Catalyst Cysteine for Synthesis, Docking Study, and Antifungal Activity of New Bio-Active 3,4-Dihydropyrimidin-2(1H)-ones/thiones Under Microwave Irradiation

et al. 2022

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An eco-friendly green bio-organic catalyst and low-cost 3,4-dihydropyrimidin-2(1 H )-ones/thione derivatives 4–7 have been synthesized using a high-yield, synthetic method via a one-pot, three-component process between 4-formylphenyl-4-methylbenzenesulfonate ( 1 ), thiourea, or urea and ethyl acetoacetate or acetylacetone under microwave irradiation in aqueous media of water and ethanol (3:1 ratio) as a green solvent in the presence of cysteine as a new green bio-organic catalyst. The reaction between compound 1 , 4-(carbamothioylhydrazono) methyl]phenyl 4-methyl benzenesulfonate ( 3c ), and ethyl acetoacetate or acetylacetone under the same condition afforded novel pyrimidines. Similarly, compound 1 was allowed to react with a mixture of 4-(carbamothioylhydrazono)methyl]phenyl 4-methyl benzenesulfonate ( 3c ) and ethyl acetoacetate or acetylacetone under the same condition to afford pyrimidine derivatives 8 and 9 . Excellent yields (90–98%) were obtained within short reaction times, and problems associated with the toxic solvents used (cost, safety, and pollution) were avoided. The structures of the new compounds were elucidated by elemental and spectral analyses. All compounds were studied using molecular docking, and their antifungal activity was investigated.

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“…Therefore, in view of these observations and in conjunction with our previous interest in the synthesis of heterocyclic rings, − we aimed here to find new insecticides for the synthesis of novel chalcone derivatives and the subsequent assessment of their toxicological and biological bio-efficacy against S. frugiperda.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and SAR Studies of Some Novel Chalcone Derivatives for Potential Insecticidal Bioefficacy Screening on Spodoptera frugiperda (Lepidoptera: Noctuidae)

et al. 2022

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Spodoptera frugiperda is a species of the order Lepidoptera. It is one of the species of fall armyworm moths distinguished by its larval life stage, is found in different regions of Africa, and can cause incredible damage. This is the first report produced by the preparation of an indexed combinatorial library of novel chalcone derivatives 3a−k via treatment of 4-formylphenyl4methylbenzenesulfonate (1) with some acetyl compounds 2a−k in the presence of NaOH. The structures of the synthesized compounds were proven by different spectroscopic techniques such as infrared, 1 H NMR, 13 C NMR, and elemental analyses. In this work, we studied their toxicity effect against S. frugiperda, followed by a structure−reaction relationship. Moreover, newly prepared chalcone derivatives were tested as insecticides using S. frugiperda. It has been found that most compounds have good to excellent potential effectiveness. Among all of the compounds, 3b, 3g, and 3j exhibited excellent effectiveness. Furthermore, compound 3c showed the most activity, with LC 50 = 9.453 ppm of the second instar larva and LC 50 = 66.930 of the fourth instar larva .

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Boosting the catalytic performance of zinc linked amino acid complex as an eco‐friendly for synthesis of novel pyrimidines in aqueous medium

Cited by 33 publications

References 42 publications

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Efficient and Recoverable Bio-Organic Catalyst Cysteine for Synthesis, Docking Study, and Antifungal Activity of New Bio-Active 3,4-Dihydropyrimidin-2(1H)-ones/thiones Under Microwave Irradiation

Design, Synthesis, and SAR Studies of Some Novel Chalcone Derivatives for Potential Insecticidal Bioefficacy Screening on Spodoptera frugiperda (Lepidoptera: Noctuidae)

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