Bootstrapping

Mooney, Christopher Z.; Duval, Robert D.

doi:10.4135/9781412983532

Cited by 842 publications

(73 citation statements)

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“…Using a bootstrap analysis we have determined the sensitivity of the solution to the existing collection of samples. The residuals from the OMP solution were randomly sampled, with 1500 iterations, to reconstruct the water mass fractions [ Mooney and Duval , 1993]. This produces a nonparametric distribution of the mean and maximum GMW fractions, which are presented at the 95% confidence.…”

Section: Discussionmentioning

confidence: 99%

An optimized estimate of glacial melt from the Ross Ice Shelf using noble gases, stable isotopes, and CFC transient tracers

et al. 2009

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[1] Isotopes of helium and neon and the H 2 18 O/H 2 16 O ratio of water are proven proxies for melt from glacial ice beneath floating ice shelves and at ice shelf fronts. Their high concentrations in glacial meltwater, compared to other environmental sources, make them ideal tracers for studies of the pathways of glacial meltwater from its origins into the ocean interior. We combine noble gas and stable isotopes with temperature, salinity, and dissolved oxygen measurements from three cruises (along the Ross Ice Shelf during the austral summers of 1993-1994 and 1999-2000 and to the Ross Sea in [2000][2001] and use optimal multiparameter analysis to compute the water mass concentration, including glacial meltwater. The distribution of meltwater at the front of the Ross Ice Shelf extended east from 180°W, with the highest concentrations found near 165°W in both 1994 and 2000. The mean meltwater concentration at the ice shelf front was 2.0 ± 0.33% in 1994, 2.2 ± 0.36% in 2000, and 0.25 ± 0.1% in the western Ross Sea in 2001. Water mass concentrations are used to correct for bias in the CFC age, introduced by mixing with CFC-free waters, an effect revealed by comparing CFC age with transit time distribution curves. The water residence time within the ice shelf cavity, using CFCs and the mean meltwater concentration, implies a basal melt rate of 33-50 km 3 a À1 .

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Section: Discussionmentioning

confidence: 99%

An optimized estimate of glacial melt from the Ross Ice Shelf using noble gases, stable isotopes, and CFC transient tracers

et al. 2009

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“…The difference between HoH and DoD infant groups was statistically evaluated using t-tests with the Satterthwaite method for unequal variances and bootstrapping to estimate 95% confidence intervals (CI) (Howell, 2013). The use of bootstrapping is increasingly common in psychological science, because it has few statistical assumptions and is appropriate with unequal group sizes (Mooney & Duval, 2011).…”

Section: Main Analysesmentioning

confidence: 99%

Enhanced gaze‐following behavior in Deaf infants of Deaf parents

Brooks

Singleton

Meltzoff

2019

Developmental Science

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Gaze following plays a role in parent–infant communication and is a key mechanism by which infants acquire information about the world from social input. Gaze following in Deaf infants has been understudied. Twelve Deaf infants of Deaf parents (DoD) who had native exposure to American Sign Language (ASL) were gender‐matched and age‐matched (±7 days) to 60 spoken‐language hearing control infants. Results showed that the DoD infants had significantly higher gaze‐following scores than the hearing infants. We hypothesize that in the absence of auditory input, and with support from ASL‐fluent Deaf parents, infants become attuned to visual‐communicative signals from other people, which engenders increased gaze following. These findings underscore the need to revise the ‘deficit model’ of deafness. Deaf infants immersed in natural sign language from birth are better at understanding the signals and identifying the referential meaning of adults’ gaze behavior compared to hearing infants not exposed to sign language. Broader implications for theories of social‐cognitive development are discussed. A video abstract of this article can be viewed at https://youtu.be/QXCDK_CUmAI

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“…To compare different protocols statistically, we estimated the error bounds of the AUE and RMSD values by performing a bootstrapping calculation [83]. We assumed that individual free energy terms,

Δ G_{rest - on}^{C}, Δ G_{elec}^{C}

, and

Δ G_{vdW}^{C}

, obey the Gaussian distribution whose mean and standard deviation are obtained from the three repetitions.…”

Section: Resultsmentioning

confidence: 99%

Absolute binding free energy calculations of CBClip host–guest systems in the SAMPL5 blind challenge

Lee

Tofoleanu

Pickard

et al. 2016

J Comput Aided Mol Des

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Herein, we report the absolute binding free energy calculations of CBClip complexes in the SAMPL5 blind challenge. Initial conformations of CBClip complexes were obtained using docking and molecular dynamics simulations. Free energy calculations were performed using thermodynamic integration (TI) with soft-core potentials and Bennett’s acceptance ratio (BAR) method based on a serial insertion scheme. We compared the results obtained with TI simulations with soft-core potentials and Hamiltonian replica exchange simulations with the serial insertion method combined with the BAR method. The results show that the difference between the two methods can be mainly attributed to the van der Waals free energies, suggesting that either the simulations used for TI or the simulations used for BAR, or both are not fully converged and the two sets of simulations may have sampled difference phase space regions. The penalty scores of force field parameters of the 10 guest molecules provided by CHARMM Generalized Force Field can be an indicator of the accuracy of binding free energy calculations. Among our submissions, the combination of docking and TI performed best, which yielded the root mean square deviation of 2.94 kcal/mol and an average unsigned error of 3.41 kcal/mol for the ten guest molecules. These values were best overall among all participants. However, our submissions had little correlation with experiments.

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Bootstrapping

Cited by 842 publications

References 0 publications

An optimized estimate of glacial melt from the Ross Ice Shelf using noble gases, stable isotopes, and CFC transient tracers

An optimized estimate of glacial melt from the Ross Ice Shelf using noble gases, stable isotopes, and CFC transient tracers

Enhanced gaze‐following behavior in Deaf infants of Deaf parents

Absolute binding free energy calculations of CBClip host–guest systems in the SAMPL5 blind challenge

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