We study the effectiveness of the numerical bootstrap techniques recently developed in [1] for quantum mechanical systems. We find that for a double well potential the bootstrap method correctly captures non-perturbative aspects. Using this technique we then investigate quantum mechanical potentials related by supersymmetry and recover the expected spectra. Finally, we also study the singlet sector of O(N ) vector model quantum mechanics, where we find that the bootstrap method yields results which in the large N agree with saddle point analysis.