2016
DOI: 10.1590/s0102-865020160030000007
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Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction

Abstract: PURPOSE:To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI). METHODS:Male Wistar rats underwent ligation of the left coronary artery and divided into three groups: MI (control), BO-18 (18 mg/ kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and processed for histological evaluation of: MI size, LV dilation, myocyte hypertrophy, inflammatory infiltration and fibrosis in MI region and in remote region. The relativ… Show more

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Cited by 5 publications
(3 citation statements)
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“…Borage oil possesses antioxidant activity which is superior compared to gamma-linolenic itself 41 . Borage oil reduced progression of cardiac remodeling after myocardial infarction and congestive heart failure in rats through attenuation of inflammatory infiltration and fibrosis in the myocardium 42 as could be seen from histopathology examination of the heart and the reduction in TNF-alpha in the present study. Gammalinolenic acid afforded protection from ventricular fibrillation in aged rats 43 .…”
Section: Discussionsupporting
confidence: 77%
“…Borage oil possesses antioxidant activity which is superior compared to gamma-linolenic itself 41 . Borage oil reduced progression of cardiac remodeling after myocardial infarction and congestive heart failure in rats through attenuation of inflammatory infiltration and fibrosis in the myocardium 42 as could be seen from histopathology examination of the heart and the reduction in TNF-alpha in the present study. Gammalinolenic acid afforded protection from ventricular fibrillation in aged rats 43 .…”
Section: Discussionsupporting
confidence: 77%
“…Two important herbal medicines used to treat heart disease are Echium amoenum and Citrus aurantium in the southern regions of Iran [ 13 ]. Studies have shown the positive role of Echium amoenum in cardiac remodeling in an animal model with MI and congestion [ 14 ]. The effect of Echium amoenum on the blood pressure and heart rate in an animal model was studied.…”
Section: Discussionmentioning
confidence: 99%
“…Based on these results, borage oil reduces development of cardiac remodeling after myocardial infarction and congestive heart failure. 30 Furthermore, it is largely acknowledged that emotional elements might impact physical function. This matter is lectured in comprehensive medicine as well as neuroscience.…”
Section: Cardiotonic Effectsmentioning
confidence: 99%