Borderline Brenner Tumor of the Ovary Coexisting With an Ovarian Mucinous Cystadenoma With Focal Atypical Epithelial Proliferation: A Rare Case With Review of the Literature

Salibay, Christine; Zanfagnin, Valentina; Miller, Heather; Walia, Saloni; Brunette, Laurie L.; Wang, Tiannan

doi:10.1177/1066896921999459

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…Based on histogenesis, the aforementioned tumors are believed to originate from analogous precursors. 19 , 20 The pathological evaluations of the patient in the present study demonstrated that a Brenner tumor is associated with mucinous metaplasia, similar to the findings of previous studies.…”

Section: Discussionsupporting

confidence: 91%

“…6 Less than 60 studies regarding borderline Brenner tumors have been published to date, and there is minimal information regarding the favorable prognosis of the aforementioned tumors alone or with mucinous neoplasms. 19 In clinical practice, detecting tumors in the early stages is essential by employing strategies for early diagnosis and early treatment. 3 The patient of the current study was followed up for 2 years after the surgery, in which no complication was reported.…”

Section: Discussionmentioning

confidence: 99%

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Borderline Brenner tumor of the ovary with mucinous metaplasia: A case report

Shiravani,

Bahrami,

Najib

et al. 2023

Clinical Case Reports

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Key Clinical MessageTo date, there have been disparate reports regarding borderline forms of Brenner tumors, while research on concomitant mucinous proliferation is even more irregular; however, it has been observed that proper diagnosis and treatment have proven to have a favorable prognosis on the aforementioned tumor.AbstractBrenner tumor is a rare epithelial ovarian neoplasm responsible for 2%–3% of all ovarian tumors. These tumors are usually asymptomatic and can usually be found incidentally in pathological studies. They can also manifest themselves as abdominal pain or abnormal uterine bleeding. A 41‐year‐old female with a history of anemia referred to the hospital suffering from abdominal pain for at least 1 month before the referral period. Physical examination revealed a mobile palpable mass in the left lower abdomen. Ultrasound and pelvic computed tomography scan (CT scan) revealed a left ovarian complex cyst. Left salpingo‐oophorectomy was performed on the patient, and the cyst was removed. Pathological findings revealed an atypical proliferative Brenner tumor with mucinous metaplasia. To date, there have been disparate reports regarding borderline forms of Brenner tumors, while research on concomitant mucinous proliferation is even more irregular; however, it has been observed that proper diagnosis and treatment have proven to have a favorable prognosis on the aforementioned tumor.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Borderline Brenner tumor of the ovary with mucinous metaplasia: A case report

Shiravani,

Bahrami,

Najib

et al. 2023

Clinical Case Reports

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“…As for the choice of surgical methods, 72.0% (18/25) were treated with total laparoscopic hysterectomy and 24.0% (6/25) with salpingooophorectomy laparoscopy. Moreover, 4% (1/25) of the patients chose open surgery, which was inconsistent with the literature reports (31). The reason may be the large size of the tumor and the presence of potential malignancy.…”

Section: Discussionmentioning

confidence: 83%

Benign Brenner tumor of the ovary: two-dimensional and contrast-enhanced ultrasound features—a retrospective study from a single center

Chen,

Liao,

Cao

et al. 2024

Front. Oncol.

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ObjectiveBenign Brenner tumor (BBT) is a rare ovarian tumor, and there are few discrete reports about its manifestation in an ultrasound. This study sought to investigate the two-dimensional (2D) and contrast-enhanced ultrasound (CEUS) features of this entity.MethodsThis is a retrospective single-center study. The clinical manifestations, laboratory examination, and ultrasound data of 25 female patients with BBT were confirmed by pathology when they underwent 2D and/or CEUS examination at Ningbo First Hospital from January 2012 to June 2023. The ultrasound findings of the patients were analyzed using the terminology of the International Organization for the Analysis of Ovarian Tumor and were read by two senior sonographers who reached an agreement.ResultsAmong the all 25 patients, most of them were unilateral, and only one patient was bilateral. Thus, 26 lesions were found: 44.0% (11/25) were in the left and 52.0% (13/25) were in the right. Moreover, 53.84% (14/26) were solid lesions, 15.38% (4/26) were mixed lesions, and 26.92% (7/26) were cystic lesions. Among the solid-type patients, 42.85% (6/14) of the cases were with calcification. Upon laboratory examination, 12.0% (3/25) of the patients had high carbohydrate antigen 125 (CA-125) level, and 19.04% (4/21) of the patients had an elevated carbohydrate antigen724 (CA-724) level in the serum tumor markers. In the hormone test, 14.28% (3/21) were found to have a high postmenopausal estrogen level and 14.28%(3/21) were found to have a high level of follicle-stimulating hormone (FSH). One patient with complex manifestations and three with solid manifestations were examined by CEUS to observe the microcirculation perfusion of the tumor. One with solid and cystic separation was rapidly hyperenhanced and cleared, and the filling subsided faster than the uterus. The postoperative pathological diagnosis was benign Brenner tumor with mucinous cystadenoma. The other three cases were solid adnexal lesions, which showed isoenhancement on CEUS and disappeared slowly, synchronizing with the uterus. The CEUS results were considered as benign tumors and confirmed by pathology.ConclusionsBBT can show ovarian cystic, mixed cystic and solid type, and solid echo in 2D ultrasound. Unilateral ovarian fibrosis with punctate calcification is an important feature of BBT in 2D ultrasound. However, for solid adnexal masses and mixed cystic and solid masses with unclear diagnosis, if CEUS shows isoenhancement or hyperenhancement, the possibility of BBT cannot be excluded.

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“…Histologically, the borderline BT exhibit a characteristic papillary arrangement of uniform stratified neoplastic cells with oval nuclei possessing longitudinal grooves. They further demonstrate a fibro-vascular core and the absence of stromal invasion [ 4 - 6 ]. This histological presentation resembles low-grade papillary urothelial neoplasms [ 1 , 7 ] and frequently includes areas with a benign Brenner component [ 1 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

An Incidental Finding of Low-Grade Appendiceal Mucinous Neoplasm in a Case of Borderline Brenner Tumor of the Ovary

Agarwal,

Chander R

2024

Cureus

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The concurrent presentation of a low-grade appendiceal mucinous neoplasm (LAMN) and a borderline Brenner tumor (BT) of the ovary are exceedingly rare. Brenner tumors stand out as a particularly uncommon form, making up only around 5% of all benign epithelial tumors of the ovary. Among the ovarian Brenner, the borderline subtype is even rarer. Appendiceal neoplasm (LAMN) and right ovarian BT cannot be distinguished due to their anatomical position. LAMN is often an incidental finding and at later stages when left undiagnosed may lead to pseudomyxoma peritonei (PMP). This case describes a postmenopausal woman in her 50s experiencing abdominal pain and bloating for a week. Elevated carcinoembryonic antigen (CEA) levels and imaging suggested a potential right ovarian tumor. Interestingly, it revealed a unique combination of borderline Brenner tumor of the right ovary and low-grade appendiceal mucinous neoplasm.

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Borderline Brenner Tumor of the Ovary Coexisting With an Ovarian Mucinous Cystadenoma With Focal Atypical Epithelial Proliferation: A Rare Case With Review of the Literature

Cited by 7 publications

References 16 publications

Borderline Brenner tumor of the ovary with mucinous metaplasia: A case report

Borderline Brenner tumor of the ovary with mucinous metaplasia: A case report

Benign Brenner tumor of the ovary: two-dimensional and contrast-enhanced ultrasound features—a retrospective study from a single center

An Incidental Finding of Low-Grade Appendiceal Mucinous Neoplasm in a Case of Borderline Brenner Tumor of the Ovary

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