Borderline ovarian tumor in women aged ≥65 years: impact on recurrence and survival

Song, Taejong; Lee, Yoo-Young; Choi, Chel Hun; Kim, Tae-Joong; Lee, Jeong‐Won; Bae, Duk-Soo; Kim, Byoung-Gie

doi:10.1016/j.ejogrb.2014.10.001

Cited by 11 publications

(6 citation statements)

References 23 publications

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“…The overall prognosis of patients with MBOTs is excellent. It was reported that the 5‐year survival rate of MBOTs was up to 90% or even higher . But the prognosis of mucinous carcinoma is much poorer, which is only 45–50%.…”

Section: Introductionmentioning

confidence: 99%

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Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Chen

Tao

et al. 2020

J of Obstet and Gynaecol

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Aim To investigate the clinicopathologic characteristic and fertility results of patients with mucinous borderline ovarian tumors (MBOTs), and the effects of intraepithelial carcinoma (IECA) on them. Methods Fifty‐two patients treated for MBOTs with or without IECA were retrospectively analyzed. Results Patients with IECA were more frequently observed at stage Ic (3/12 vs 1/40, P = 0.034) and accompanied by microinvasive carcinoma (3/12 vs 1/40, P = 0.034). The detected rate of IECA by intraoperative frozen section (5/12, 41.7%) was much lower than that of MBOTs (82.5%, P = 0.010). About 61.5% patients in our study underwent fertility‐sparing surgery. Follow‐up information was retained completely in 41 patients. And all four tumor recurrences were observed (9.8%) in conservative surgery group in 66 months, though there was no statistical association (P = 0.280). There were three patients who recurred more than once, even one occurred tumor‐related death. Only one recurrent patient was in IECA group (P > 0.05). However, patients with IECA were more likely to receive adjuvant chemotherapy (3 of 12 vs 0 of 40, P = 0.010) and surgical staging (75% vs 52.5%, P = 0.200). As for fertility results, nine patients wished to be pregnant and seven of them (77.8%) were successful. Conclusion For young patients with MBOTs, fertility results are satisfactory after conservative surgery. But patients should be fully informed about the relative high recurrent rate. And IECA has no statistical negative effects on MBOTs till now, but a long‐term follow‐up is required.

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Section: Introductionmentioning

confidence: 99%

“…It was reported that the 5-year survival rate of MBOTs was up to 90% or even higher. 5,6 But the prognosis of mucinous carcinoma is much poorer, which is only 45-50%. For advanced stage ovarian cancer, it is even lower to 5-10%.…”

Section: Introductionmentioning

confidence: 99%

Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Chen

Tao

et al. 2020

J of Obstet and Gynaecol

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“…The incidence of BOTs is 1.8–4.8 cases per 100,000 females per year 5. They typically have an excellent prognosis with an overall 10 year survival rate of 83-91% 6,7. They are predominantly diagnosed in pre-menopausal females aged 34–40 years and are rare in women who are 65 years of age or older 5.…”

Section: Introductionmentioning

confidence: 99%

“… 5 They typically have an excellent prognosis with an overall 10 year survival rate of 83-91%. 6 , 7 They are predominantly diagnosed in pre-menopausal females aged 34–40 years and are rare in women who are 65 years of age or older. 5 Histopathologically, this group of neoplasms exhibit behaviour that is intermediate between benign cyst-adenomas and invasive carcinomas.…”

Section: Introductionmentioning

confidence: 99%

Borderline tumors of the ovary: A clinicopathological study

et al. 2017

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Objective:To report experience with borderline ovarian tumors (BOTs) in a developing country like Pakistan with limited resources and weak database of health system.Methods:Patients with BOTs managed at Shaukat Khanum Cancer hospital, Lahore, Pakistan from 2004 to 2014 were included and reviewed retrospectively. Data was recorded on histopathological types, age, CA-125, stage of disease, treatment modalities and outcomes.Results:Eighty-six patients with BOT were included with a median age of 35 years. Forty-two (49%) patients had serous BOTs and 43 (50%) had mucinous BOTs, while one (1%) had mixed type. Using FIGO staging, 80 patients had stage I; two patients had IIA, IIB and stage III each. Median follow-up time was 31.5 months. All patients had primary surgery. Seventy (81%) patients underwent complete surgical resection of tumor. Forty-three (50%) patients had fertility preserving surgery. Seventy-three (85%) patients remained in remission. Recurrent disease was observed in 13 (15%) patients. Median time to recurrence was 22 months. On further analysis, age above forty years, late stage at diagnosis and incomplete surgery were significantly associated with invasive recurrence.Conclusion:Despite a low malignant potential, relapses may occur in patients above forty years of age, incomplete surgery and staging information and advanced stage at presentation. Fertility sparing surgery should be considered in young patients. Complete excision of tumor and prolonged follow-up are advised because recurrence and transformation to invasive carcinoma may occur.

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“…Previous studies showed that FST can be tolerated in BOT patients and the ability of pregnancy was persevered [10,11], while other studies revealed that the risk of recurrence, or even death, may be increased in patients receiving FST [12][13][14]. As we known, FST has various surgical procedure types including salpingooophorectomy and cystectomy.…”

Section: Introductionmentioning

confidence: 99%

Salpingo-oophorectomy versus cystectomy in patients with borderline ovarian tumors: a systemic review and meta-analysis on postoperative recurrence and fertility

Wang

Fang

2021

World J Surg Onc

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Background To compare the postoperative recurrence and fertility in patients with borderline ovarian tumors (BOTs) who underwent different surgical procedures: salpingo-oophorectomy versus cystectomy. Methods Potentially relevant literature from inception to Nov. 06, 2020, were retrieved in databases including Cochrane Library, EMBASE (Ovid), and MEDLINE (Pubmed). We applied the keywords “fertility-sparing surgery,” or “conservative surgery,” or “cystectomy,” or “salpingo-oophorectomy,” or “oophorectomy,” or “adnexectomy,” or “borderline ovarian tumor” for literate searching. Systemic reviews and meta-analyses were performed on the postoperative recurrence rates and pregnancy rates between patients receiving the two different surgical methods. Begger’s methods, Egger’s methods, and funnel plot were used to evaluate the publication bias. Result Among the sixteen eligible studies, the risk of recurrence was evaluated in all studies, and eight studies assessed the postoperative pregnancy rates in the BOT patients. A total of 1839 cases with borderline ovarian tumors were included, in which 697 patients (37.9%) received unilateral salpingo-oophorectomy and 1142 patients (62.1%) underwent unilateral/bilateral cystectomy. Meta-analyses showed that BOT patients with unilateral/bilateral cystectomy had significantly higher recurrence risk (OR=2.02, 95% CI: 1.59-2.57) compared with those receiving unilateral salpingo-oophorectomy. Pooled analysis of four studies further confirmed the higher risk of recurrence in patients with cystectomy (HR=2.00, 95% CI: 1.11-3.58). In addition, no significant difference in postoperative pregnancy rate was found between patients with the two different surgical procedures (OR=0.92, 95% CI: 0.60-1.42). Conclusion Compared with the unilateral/bilateral cystectomy, the unilateral salpingo-oophorectomy significantly reduces the risk of postoperative recurrence in patients with BOT, and it does not reduce the pregnancy of patients after surgery. Trial registration PROSPERO CRD42021238177

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Borderline ovarian tumor in women aged ≥65 years: impact on recurrence and survival

Cited by 11 publications

References 23 publications

Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Borderline tumors of the ovary: A clinicopathological study

Salpingo-oophorectomy versus cystectomy in patients with borderline ovarian tumors: a systemic review and meta-analysis on postoperative recurrence and fertility

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