Borderline Serous Cystadenocarcinoma with Coexistent Angiosarcoma: An Unusual Form of Ovarian Carcinosarcoma

Pillay, Komala; Essa, Ahmed S.; Chetty, Runjan

doi:10.1177/106689690100900411

Cited by 24 publications

(14 citation statements)

References 13 publications

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“…Ovarian sarcomas may be associated with surface epithelial-stromal tumors, particularly serous and mucinous tumors, the so-called mural nodules. These tumors must be distinguished from metastatic sarcoma to the ovary [1–5, 8]. In this paper, the authors described a case of angiosarcoma associated with an ovarian stromal/sex cord differentiation tumor, which corresponded to a fibroma, not currently being found this association in literature.…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma Arising in an Ovarian Fibroma: A Case Report

Cambruzzi

Pêgas

Milani

et al. 2010

Pathology Research International

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Primary ovarian angiosarcoma is a very rare gynaecological sarcoma, with poor prognosis. These tumors are though to arise from carcinosarcomas, teratomas, or the ovarian vasculature and occur at any age. There are only a few cases reported in the international literature, most commonly associated to surface epithelial-stromal or germ cell tumours. Herein, the authors report the clinicopathologic features of an angiosarcoma arising in an ovarian fibroma. A 65-year-old patient was admitted with a palpable mass in the hypogastrium. Grossly, the removed ovary was completely replaced by a solid tumor mass. On histological analysis, the lesion revealed the typical histological features of angiosarcoma with sinusoidal patterns and anaplastic cells, admixed with spindle-shaped cells arranged in fascicles or in a storiform pattern, compatible with a fibroma. The vascular component was strongly immunopositive for CD31 and CD34. The patient was submitted to chemotherapy, and she was alive for two months after surgical proceedings.

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Section: Discussionmentioning

confidence: 99%

Angiosarcoma Arising in an Ovarian Fibroma: A Case Report

Cambruzzi

Pêgas

Milani

et al. 2010

Pathology Research International

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“…Seven of these cases were associated with ovarian teratomatous origin [4, 10]. Six cases of ovarian angiosarcoma were associated with ovarian epithelial neoplasms: one with serous borderline tumor (age 45 years) [11] and the other 5 cases with mucinous tumors (age 29 to 77 years) [2]. Of these 5 cases, 3 had mucinous cystadenoma (age 29, 39, and 77 years) [1, 5, 7] and 2 had microinvasive or invasive mucinous adenocarcinoma (age 37 and 54 years) [2, 6].…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma Arising in Ovarian Mucinous Tumor: A Challenge in Intraoperative Frozen Section Diagnosis

Khunamornpong

Settakorn

Sukpan

et al. 2016

Case Reports in Pathology

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Angiosarcoma of the ovary is rare but represents an aggressive type of malignant ovarian neoplasms. The purpose of this report is to describe the features of angiosarcoma arising in mucinous tumor that was misinterpreted as a benign vascular proliferation during the intraoperative consultation. A 45-year-old woman presented with an abdominal mass for 1 month. Exploratory laparotomy was performed. A 35 cm right ovarian mass submitted for intraoperative consultation was a multicystic mucinous tumor with an 8 cm area of hemorrhagic lesion between cystic locules. The frozen section diagnosis was at least mucinous borderline tumor. The hemorrhagic area, which was intraoperatively interpreted as organizing vessels associated with previous hemorrhage, represented angiosarcoma in permanent sections. Angiosarcoma may present a challenge in intraoperative frozen section diagnosis of an ovarian mass. The presence of ectatic anastomosing vessels with dissecting growth appears to be the clue to a suspicion of angiosarcoma. The presence of endothelial atypia provides further support for the diagnosis. A macroscopic hemorrhagic area in an ovarian mucinous tumor should be evaluated with care, and the possibility of angiosarcoma should be borne in mind.

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“…[4], two arose in a dermoid cyst. Two of the cases of ovarian angiosarcoma were associated with a coexistent borderline or invasive epithelial neoplasm: one case with a mucinous cystadenocarcinoma and another with a serous neoplasm of low malignant potential [9,10]. Recently, cases of angiosarcoma arising in mucinous cystadenoma and ovarian fibroma have also been reported [11,12].…”

Section: Introductionmentioning

confidence: 99%

Ovarian angiosarcoma: a case report and review of the literature

et al. 2014

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Introduction: Sarcomas of the ovary can either be histologically pure or can represent components of a more complex tumor. Ovarian angiosarcomas are rare, and probably arise from carcinosarcomas, teratomas or the rich ovarian vasculature. To date, only two small case series have been published, one with four cases and the other with seven. Case presentation: A 41-year-old Saudi woman presented to our gynecological clinic with abnormal vaginal bleeding. The initial clinical diagnosis was left ovarian cyst. The results of the remainder of her abdominopelvic examination were normal. Peri-operatively, the left ovarian mass resembled a hemorrhagic solid tumor. It was sent for frozen sectioning, which revealed it was an undifferentiated neoplasm. The final histopathological examination showed a vascular neoplasm showing vasoformative arborizing channels of variable sizes and shapes lined by atypical endothelial cells with intact capsule. Areas of necrosis were seen, along with fused anastomosing solid vascular area. She was diagnosed as having an angiosarcoma of intermediate grade, International Federation of Gynecology and Obstetrics stage IA. Conclusions: Patients with ovarian angiosarcomas most commonly present with abdominal pain, however some patients present with distant metastases, often in the lungs. Spread beyond the ovary is present at the time of diagnosis in most reported cases, with disease progression within less than a year after diagnosis. Cases of advanced stage disease behave aggressively and demonstrate poor response to surgery and chemotherapy, with an overall poor prognosis. They have a tendency for local recurrence and metastases, and prognosis is hence poor; the reported five-year survival rate is 10 percent to 35 percent, however, cases confined to the ovary have survived up to nine years.

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Borderline Serous Cystadenocarcinoma with Coexistent Angiosarcoma: An Unusual Form of Ovarian Carcinosarcoma

Cited by 24 publications

References 13 publications

Angiosarcoma Arising in an Ovarian Fibroma: A Case Report

Angiosarcoma Arising in an Ovarian Fibroma: A Case Report

Angiosarcoma Arising in Ovarian Mucinous Tumor: A Challenge in Intraoperative Frozen Section Diagnosis

Ovarian angiosarcoma: a case report and review of the literature

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