Bordetella pertussis toxins

Accumulation of a precursor of subunit S1 of pertussis toxin in cell envelopes of Bordetella pertussis in response to the membrane perturbant phenethyl alcohol

“…The localisation of of PT are synthesised and to elucidate the way in which PT is released into the culture medium. the histamine-sensitising activity (attributed to PT by Wardlaw and Parton, 1982) mainly in the outer membrane of B. pertussis strain Tohama (Imagawa et al, 1979) may substantiate this view. Further work is in progress to determine how other subunits…”

“…Bordetellapertussis, the causative agent of whooping cough in man, produces at least four distinct toxins-heat-labile toxin, lipopolysaccharide endotoxin, tracheal cytotoxin and pertussis toxin (PT) (Wardlaw and Parton, 1982). PT, the major virulence determinant responsible for some of the clinical manifestations of whooping cough (Wardlaw and Parton, 1982), consists of five dissimilar subunits S1-5 with apparent mol.…”

“…PT, the major virulence determinant responsible for some of the clinical manifestations of whooping cough (Wardlaw and Parton, 1982), consists of five dissimilar subunits S1-5 with apparent mol. wts (lo3) of 28, 23,22, 11 and 9, respectively (Tamura et al, 1982).…”

Identification of an active‐site residue in subunit S1 of pertussis toxin by photocrosslinking to NAD

“…Pertussis toxin (PT), an exotoxin of Bordetella pertussis, is believed to be an important pathogen and immunogen associated with whooping cough [1]. Recent achievements in sequencing the PT gene [2,3] have stimulated interest in detoxifying the toxin by genetic engineering [4].…”

Cytopathic Effect of Heat‐Labile Toxin of Bordetella parapertussis on Aortic Smooth Muscle Cells from Pigs or Guinea Pigs

“…Phase I bacteria of Bordetella species similarly produce the heat-labile toxin (HLT) inducing hemorrhagic necrosis characterized by its surrounding ischemic region in guinea pigs and rabbits (10). Using a purified HLT we previously found that it had a vasoconstrictive effect not only on the peripheral arterioles in guinea pig skin but also on those in the perfused lung preparation in vitro, though it failed to act on isolated preparations of ductus deferens (3)(4)(5).…”