Boric acid enhances in vivo Ehrlich ascites carcinoma cell proliferation in Swiss albino mice

Qureshi, Shoeb; Al‐Shabanah, Othman A.; Alharbi, Metab; Al‐Bekairi, Abdullah M.; Raza, Muhammad Asif

doi:10.1016/s0300-483x(01)00396-1

Cited by 42 publications

(25 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The anticancer activities of the compound were measured in EAC treated animals with respect to the body weight, tumor volume and tumor weight, packed cell volume, tumor cell count, viable and non viable tumor cell count (Qureshi et al 2001). …”

Section: Anticancer Activitymentioning

confidence: 99%

Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn aerial parts against Ehrlich Ascites Carcinoma in mice

Ghosh¹,

Maity

Singh

2011

Orient Pharm Exp Med

View full text Add to dashboard Cite

Cancer remains as one of the most common cause of mortality worldwide. Cancer chemoprevention by natural products is well accepted nowadays. Phytoserols are natural products, showing anticancer activity, besides other activities. The purpose of this study was to examine the antitumor and antioxidant activity of stigmasterol, a phytosterol isolated from aerial parts of Bacopa monnieri Linn. against Ehrlich Ascites Carcinoma (EAC) in swiss albino mice. The effect of stigmasterol on the growth of transplantable murine tumor, life span of EAC bearing hosts, simultaneous alterations in the hematological profile, liver biochemical parameters (lipid peroxidation, antioxidant enzymes) and histopthological studies of liver were examined. Stigmasterol decreased tumor volume, packed cell volume and viable cell count, and increased mean survival time thereby increasing life span of EAC tumor bearing mice. Hematological profile reverted to near normal levels in stigmasterol treated mice. Stigmasterol decreased the levels of lipid peroxidation and increased the levels of glutathione, superoxide dismutase and catalase in the liver of EAC bearing mice. Histopathological study of liver tissues showed that stigmasterol had significant protective effect against EAC bearing mice, which corroborates the above findings. Lactate dehydrogenase (LDH) activity in ascitic fluid increased while membrane microviscosity of the EAC cells decreased upon stigmasterol treatment indicating its effect in the membrane integrity functions. The antitumor activity of stigmasterol might be mediated through the activation of protein phosphatase 2A by ceramide causing apoptosis, as is shown by structurally similar phytosterol.

show abstract

Section: Anticancer Activitymentioning

confidence: 99%

Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn aerial parts against Ehrlich Ascites Carcinoma in mice

Ghosh¹,

Maity

Singh

2011

Orient Pharm Exp Med

View full text Add to dashboard Cite

show abstract

“…Owing to the toxicity of PBA, 35 it was important to verify the innocuous nature of PBACS conjugates in the present work. A series of experiments were carried out to evaluate PBACS potential toxicity.…”

Section: Cell Toxicity Assaysmentioning

confidence: 99%

Phenylboronic Acid Grafted Chitosan as a Glucose-Sensitive Vehicle for Controlled Insulin Release

Zhang

et al. 2011

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…Since most of the boronated moieties and their derivatives have cytotoxic activity in multiple cell lines [10], it was necessary to evaluate the innocuous nature of the polymerized carbohydrate moieties present in p(LAMA-r-AAPBA-r-MPEGMA) glycopolymers. Caco-2 cells were used to assess in vitro cytotoxicity assays of p(LAMA-r-AAPBA-r-MPEGMA) sub-micro particles after 48 postincubation by the MTT method (Fig.…”

Section: Cell Viabilitymentioning

confidence: 99%

“…Noted that phenylboronic acid responds to sialic acid much better than glucose and even slightly better than fructose [9], favoring the glycopolymers binding to cell surface, increasing transport of macromolecule through the respiratory epithelia. However, a disadvantage of boronic acid-containing compounds is that they have some degree of cytotoxic activity [10]. In order to overcome this shortcoming, it is necessary to introduce biocompatible compounds.…”

Section: Introductionmentioning

confidence: 99%

Random amphiphilic copolymeric sub-micro particles as a carrier shielding from enzymatic attack for peptides and proteins delivery

Meng

Tian

Wang

2012

J Mater Sci: Mater Med

View full text Add to dashboard Cite

The development of peptide drugs and therapeutic proteins is limited by their rapid clearance in liver and other body tissues by proteolytic enzymes, and consequently peptides and proteins are difficult to administer except by injection. There is a growing effort to circumvent these problems by designing strategies to deliver these drugs to specific site of the body. Among them, this peptide carrier presents several advantages for protein therapy including stability in physiological buffer and lack of toxicity. Here, we have been developing a novel bioadhesive polymer matrix that protects entrapped proteins and peptides from degradation by serine protease. Poly(2-lactobionamidoethyl methacrylate-ran-3-acrylamidophenylboronic acid-ran-methoxypolyethylene glycol methacrylate) glycopolymers were synthesized and could self-assemble into the sub-micro particles. The loading capability of insulin, as a drug model, and the insulin release from the particles were assessed. The inhibitory effect of the particles toward trypsin, elastase, and chymotrypsin was evaluated in vitro. Insulin was effectively encapsulated, up to 10%, and could be stained release in vitro. These glycopolymers displayed a strong inhibitory effect toward these exopeptidases. Therefore, novel glycopolymers with excellent inhibitory activity against proteolytic enzymes and reasonable mucoadhesivity might be a useful tool in overcoming the enzymatic barrier to the mucosal delivery (e.g. nasal and buccal) of therapeutic peptides or proteins.

show abstract

Boric acid enhances in vivo Ehrlich ascites carcinoma cell proliferation in Swiss albino mice

Cited by 42 publications

References 38 publications

Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn aerial parts against Ehrlich Ascites Carcinoma in mice

Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn aerial parts against Ehrlich Ascites Carcinoma in mice

Phenylboronic Acid Grafted Chitosan as a Glucose-Sensitive Vehicle for Controlled Insulin Release

Random amphiphilic copolymeric sub-micro particles as a carrier shielding from enzymatic attack for peptides and proteins delivery

Contact Info

Product

Resources

About