Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

Racková, Sylva; Janů, Luboš

doi:10.5772/25671

Psychiatric Disorders - Worldwide Advances 2011

DOI: 10.5772/25671

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Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

Sylva Racková¹,

Luboš Janů²

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2014

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Cited by 2 publications

References 121 publications

(88 reference statements)

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An Association of Virus Infection with Type 2 Diabetes and Alzheimer’s Disease

Karim¹,

Mirza

Kamal³

et al. 2014

CNSNDDT

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Diabetes mellitus type 2 is a metabolic disorder characterized by high blood glucose due to insulin deficiency or resistance. Alzheimer's disease (AD) is a complex neurodegenerative disease leading to irreversible loss of neurons, intellectual abilities, memory and reasoning. The worldwide prevalence of diabetes and AD in elderly population is a major public health concern. Interestingly, both health issues are unraveling the puzzling links. The clinico-pathological relationship between diabetes and AD has been reported at genomic and proteomic levels. The association of virus infection in type 2 diabetes mellitus and AD has been reported in few recent studies, some have shown direct evidence of virus infection in diabetes and AD while other have shown that diabetes increases the risk of developing AD. This review aims to summarize the association of few common viruses like Hepatitis C Virus and Herpes Simplex Virus-1 which affects both these two age-related devastating diseases. We also discuss the pathological links of Influenza virus, Cytomegalovirus, West Nile virus, Enterovirus, Herpes Simplex Virus-2, Hepatitis viruses in diabetes and Influenza virus, Picornavirus and Borna disease virus in AD. Establishing such relationships and defining their common pathogenesis and patho-physiological mechanisms may lead to new concepts and paths for developing novel preventive strategies and pharmacological treatment options for diabetes and AD. This study may aid in future for the identification of a single or a panel of likely blood-based viral biomarkers for early diagnosis of diabetes and AD with high sensitivity and specificity.

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An Association of Virus Infection with Type 2 Diabetes and Alzheimer’s Disease

Karim¹,

Mirza

Kamal³

et al. 2014

CNSNDDT

View full text Add to dashboard Cite

show abstract

The Role of Viruses in Neurodegenerative and Neurobehavioral Diseases

Karim¹,

Mirza

Kamal³

et al. 2014

CNSNDDT

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Neurodegenerative and neurobehavioral diseases may be caused by chronic and neuropathic viral infections and may result in a loss of neurons and axons in the central nervous system that increases with age. To date, there is evidence of systemic viral infections that occur with some neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, autism spectrum disorders, and HIV-associated neurocognitive disorders. With increasing lifespan, the incidence of neurodegenerative diseases increases consistently. Neurodegenerative diseases affect approximately 37 million people worldwide and are an important cause of mortality. In addition to established non-viral-induced reasons for neurodegenerative diseases, neuropathic infections and viruses associated with neurodegenerative diseases have been proposed. Neuronal degeneration can be either directly or indirectly affected by viral infection. Viruses that attack the human immune system can also affect the nervous system and interfere with classical pathways of neurodegenerative diseases. Viruses can enter the central nervous system, but the exact mechanism cannot be understood well. Various studies have supported viral- and non-viral-mediated neurodegeneration at the cellular, molecular, genomic and proteomic levels. The main focus of this review is to illustrate the association between viral infections and both neurodegenerative and neurobehavioral diseases, so that the possible mechanism and pathway of neurodegenerative diseases can be better explained. This information will strengthen new concepts and ideas for neurodegenerative and neurobehavioral disease treatment.

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Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

Cited by 2 publications

References 121 publications

An Association of Virus Infection with Type 2 Diabetes and Alzheimer’s Disease

An Association of Virus Infection with Type 2 Diabetes and Alzheimer’s Disease

The Role of Viruses in Neurodegenerative and Neurobehavioral Diseases

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