(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission

Wang, Yu; Qiu, Xiaoyun; Liu, Jiaying; Tan, Bei; Wang, Fei; Sun, Minjuan; Jiang, Xu; Ji, Xuming; Xu, Cenglin; Wang, Yi; Chen, Zhong

doi:10.1038/s41401-023-01075-w

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…[4] As examples, many monoterpenes present anticonvulsant activity, such as baldrinal, [5] pinene, [6] and borneol. [7] Tetrahydrolinalool (THL) is an acyclic monoterpene presenting as a colorless liquid with a pleasant fragrance. [8] This does not exist of effects related to genotoxicity, phototoxicity or photoallergenicity, according to data obtained from experimental tests using in vitro and in vivo models.…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches

Fonsêca,

da Silva,

Pires

et al. 2024

ChemMedChem

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Tetrahydrolinalool (THL) is an acyclic monoterpene alcohol, produced during linalol metabolism and also a constituent of essential oils. As described in the literature, many monoterpenes present anticonvulsant properties, and thus we became interested in evaluating the anticonvulsant activity of Tetrahydrolinalool using in mice model as well as in silico approaches. Our results demonstrated that THL increased latency to seizure onset and also reduced the mortality, in picrotoxin induced seizure tests. The results may be related to GABAergic regulation, which was also suggested in seizure testing induced by 3‐mercapto‐propionic acid. In the strychnine‐induced seizure testing, none of the groups pretreated with THL modulated the parameters indicative of anticonvulsant effect. The electrophysiological results revealed that THL treatment reduces seizures induced by pentylenetetrazole. The in silico molecular docking studies showed that the interaction between THL and a GABAA receptor model formed a stable complex, in comparison to the crystaligraphic structure of diazepam, a structurally related ligand. In conclusion, all the evidences showed that THL presents effective anticonvulsant activity related to the GABAergic pathway, being a candidate for treatment of epileptic syndromes.

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Section: Introductionmentioning

confidence: 99%

Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches

Fonsêca,

da Silva,

Pires

et al. 2024

ChemMedChem

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Enriched Environment Reduces Seizure Susceptibility via Entorhinal Cortex Circuit Augmented Adult Neurogenesis

Li,

Chen,

Fei

et al. 2024

Advanced Science

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Enriched environment (EE), characterized by multi‐sensory stimulation, represents a non‐invasive alternative for alleviating epileptic seizures. However, the mechanism by which EE exerts its therapeutic impact remains incompletely understood. Here, it is elucidated that EE mitigates seizure susceptibility through the augmentation of adult neurogenesis within the entorhinal cortex (EC) circuit. A substantial upregulation of adult hippocampal neurogenesis concomitant with a notable reduction in seizure susceptibility has been found following exposure to EE. EE‐enhanced adult‐born dentate granule cells (abDGCs) are functionally activated during seizure events. Importantly, the selective activation of abDGCs mimics the anti‐seizure effects observed with EE, while their inhibition negates these effects. Further, whole‐brain c‐Fos mapping demonstrates increased activity in DG‐projecting EC CaMKIIα+ neurons in response to EE. Crucially, EC CaMKIIα+ neurons exert bidirectional modulation over the proliferation and maturation of abDGCs that can activate local GABAergic interneurons; thus, they are essential components for the anti‐seizure effects mediated by EE. Collectively, this study provides compelling evidence regarding the circuit mechanisms underlying the effects of EE treatment on epileptic seizures, shedding light on the involvement of the EC‐DG circuit in augmenting the functionality of abDGCs. This may help for the translational application of EE for epilepsy management.

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Medicinal plants for epileptic seizures: Phytoconstituents, pharmacology and mechanisms revisited

He,

Chen,

Yang

et al. 2024

Journal of Ethnopharmacology

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(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission

Cited by 5 publications

References 37 publications

Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches

Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches

Enriched Environment Reduces Seizure Susceptibility via Entorhinal Cortex Circuit Augmented Adult Neurogenesis

Medicinal plants for epileptic seizures: Phytoconstituents, pharmacology and mechanisms revisited

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