Boron Carbide Particle as a Boron Compound for Boron Neutron Capture Therapy

Iwagami, Takaki; Ishikawa, Yoshie; Koshizaki, Naoto; Yamamoto, Naofumi; Tanaka, Hiroki; Masunaga, Shin‐ichiro; Sakurai, Yoshinori; Kato, Ikunoshin; Iwai, Shinichi; Suzuki, Minoru; Yura, Yoshiaki

doi:10.4172/2155-9619.1000177

Cited by 14 publications

(10 citation statements)

References 21 publications

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“…PLML can produce submicrometre spherical particles of various materials, such as metals [7,8], oxides [5,6,9], semiconductors [10,11] and carbides [3,4]. Given the unique features of submicrometre spherical particles—including their dispersibility, stability, crystallinity and sphericity—applications utilizing optical [5,12], medical [13], mechanical [14,15] and magnetic [16] functionality have been examined.…”

Section: Introductionmentioning

confidence: 99%

Determining the Composite Structure of Au-Fe-Based Submicrometre Spherical Particles Fabricated by Pulsed-Laser Melting in Liquid

et al. 2019

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Submicrometre spherical particles made of Au and Fe can be fabricated by pulsed-laser melting in liquid (PLML) using a mixture of Au and iron oxide nanoparticles as the raw particles dispersed in ethanol, although the detailed formation mechanism has not yet been clarified. Using a 355 nm pulsed laser to avoid extreme temperature difference between two different raw particles during laser irradiation and an Fe2O3 raw nanoparticle colloidal solution as an iron source to promote the aggregation of Au and Fe2O3 nanoparticles, we performed intensive characterization of the products and clarified the formation mechanism of Au-Fe composite submicrometre spherical particles. Because of the above two measures (Fe2O3 raw nanoparticle and 355 nm pulsed laser), the products—whether the particles are phase-separated or homogeneous alloys—basically follow the phase diagram. In Fe-rich range, the phase-separated Au-core/Fe-shell particles were formed, because quenching induces an earlier solidification of the Fe-rich component as a result of cooling from the surrounding ethanol. If the particle size is small, the quenching rate becomes very rapid and particles were less phase-separated. For high Au contents exceeding 70% in weight, crystalline Au-rich alloys were formed without phase separation. Thus, this aggregation control is required to selectively form homogeneous or phase-separated larger submicrometre-sized particles by PLML.

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Section: Introductionmentioning

confidence: 99%

Determining the Composite Structure of Au-Fe-Based Submicrometre Spherical Particles Fabricated by Pulsed-Laser Melting in Liquid

et al. 2019

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“…Boron carbide (B 4 C), endowed with high neutron absorptivity, has been studied as a possible material for BNCT agents [ 156 ]. For example, Mortensen et al [ 94 ] evaluated the potential use of B 4 C NPs in T cell-guided BNCT, and, to improve cellular adhesion and uptake, functionalized their B 4 C NPs with the transactivator of transcription (TAT) peptide, proving their efficacy as BNCT agents in a murine melanoma model [ 95 ].…”

Section: Nanoparticles For Bnctmentioning

confidence: 99%

Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment

Ailuno

Balboni

Caviglioli

et al. 2022

Cells

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Boron neutron capture therapy is a low-invasive cancer therapy based on the neutron fission process that occurs upon thermal neutron irradiation of 10B-containing compounds; this process causes the release of alpha particles that selectively damage cancer cells. Although several clinical studies involving mercaptoundecahydro-closo-dodecaborate and the boronophenylalanine–fructose complex are currently ongoing, the success of this promising anticancer therapy is hampered by the lack of appropriate drug delivery systems to selectively carry therapeutic concentrations of boron atoms to cancer tissues, allowing prolonged boron retention therein and avoiding the damage of healthy tissues. To achieve these goals, numerous research groups have explored the possibility to formulate nanoparticulate systems for boron delivery. In this review. we report the newest developments on boron vehiculating drug delivery systems based on nanoparticles, distinguished on the basis of the type of carrier used, with a specific focus on the formulation aspects.

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“…Recently, boron carbide was newly applied in medical applications, for example, as a carrier in boron neutron capture therapy (BNCT) [5]. This therapy uses the neutron capture reaction of the nuclei of non-radioactive boron, 10 B, which results in the unstable nucleus 11 B, which decays into an α particle and a recoiled lithium nucleus, 7 Li.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, there have been reports on the use of boron carbide in BNCT therapy. One such research method consists of the treatment of oral squamous cell carcinoma with B 4 C particles encapsulated in a graphitic layer with an approximately 200 nm size, which resulted in the decrease in the survival of cells in vitro and the inhibition of tumor growth in vivo after exposure to a neutron beam [5,19]. Another in vitro study showed that murine EL4 thymoma cells and B16 F10 malignant melanoma cells loaded with coated boron carbide nanoparticles prior to exposure to neutron irradiation were able to inhibit the proliferative capacity of untreated neighboring cells [19].…”

Section: Introductionmentioning

confidence: 99%

Boron-Rich Boron Carbide Nanoparticles as a Carrier in Boron Neutron Capture Therapy: Their Influence on Tumor and Immune Phagocytic Cells

et al. 2021

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The aim of the work was to study the interaction between boron-rich boron carbide nanoparticles and selected tumor and immune phagocytic cells. Experiments were performed to investigate the feasibility of the application of boron carbide nanoparticles as a boron carrier in boron neutron capture therapy. Boron carbide powder was prepared by the direct reaction between boron and soot using the transport of reagents through the gas phase. The powder was ground, and a population of nanoparticles with an average particle size about 80 nm was selected by centrifugation. The aqueous suspension of the nanoparticles was functionalized with human immunoglobulins or FITC-labeled human immunoglobulins and was then added to the MC38 murine colon carcinoma and to the RAW 264.7 cell line of mouse macrophages. Flow cytometry analysis was used to determine interactions between the functionalized boron carbide nanoparticles and respective cells. It was shown that B4C–IgG nanoconjugates may bind to phagocytic cells to be internalized by them, at least partially, whereas such nanoconjugates can only slightly interact with molecules on the cancer cells’ surface.

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Boron Carbide Particle as a Boron Compound for Boron Neutron Capture Therapy

Cited by 14 publications

References 21 publications

Determining the Composite Structure of Au-Fe-Based Submicrometre Spherical Particles Fabricated by Pulsed-Laser Melting in Liquid

Determining the Composite Structure of Au-Fe-Based Submicrometre Spherical Particles Fabricated by Pulsed-Laser Melting in Liquid

Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment

Boron-Rich Boron Carbide Nanoparticles as a Carrier in Boron Neutron Capture Therapy: Their Influence on Tumor and Immune Phagocytic Cells

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