Boron-doped multi-walled carbon nanotubes as sensing material for analysis of dopamine and epinephrine in presence of uric acid

Tsierkezos, Nikos G.; Ritter, Uwe; Thaha, Yudi Nugraha; Knauer, Andrea; Fernandes, Diogo; Kelarakis, Antonios; McCarthy, Eoin K.

doi:10.1016/j.cplett.2018.09.007

Cited by 28 publications

(14 citation statements)

References 55 publications

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“…In addition, they provide a large active surface area and an electrocatalytic activity that are advantageous in the development of electrochemical transducers [17,21,22]. Several CNTs and graphene-based NT sensors have been reported [23][24][25] with enhanced catalytic activity, wherein metallic nanoparticles (NPs) are anchored to both graphene and CNT substrate to provide excellent electron mediation for electron transfer between nanoparticles and substrate. Furthermore, NPs are widely used to modify the electrode surface due to their large specific surface areas, excellent conductivities, and catalytic activities.…”

Section: Neurosensing Via Cyclic Voltammetrymentioning

confidence: 99%

Electrochemical Detection of Neurotransmitters

et al. 2020

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Neurotransmitters are important chemical messengers in the nervous system that play a crucial role in physiological and physical health. Abnormal levels of neurotransmitters have been correlated with physical, psychotic, and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, dementia, addiction, depression, and schizophrenia. Although multiple neurotechnological approaches have been reported in the literature, the detection and monitoring of neurotransmitters in the brain remains a challenge and continues to garner significant attention. Neurotechnology that provides high-throughput, as well as fast and specific quantification of target analytes in the brain, without negatively impacting the implanted region is highly desired for the monitoring of the complex intercommunication of neurotransmitters. Therefore, it is crucial to develop clinical assessment techniques that are sensitive and reliable to monitor and modulate these chemical messengers and screen diseases. This review focuses on summarizing the current electrochemical measurement techniques that are capable of sensing neurotransmitters with high temporal resolution in real time. Advanced neurotransmitter sensing platforms that integrate nanomaterials and biorecognition elements are explored.

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Section: Neurosensing Via Cyclic Voltammetrymentioning

confidence: 99%

Electrochemical Detection of Neurotransmitters

et al. 2020

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“…Composites of gold nanoparticles with conducting polymers have also been used for the selective determination of dopamine [11]. Boron-doped carbon nanotubes could be used to determine levels of dopamine and ephedrine in the presence of urate [12]. Composites of graphene oxide with Bi 2 S 3 nanorods were used for the electrochemical determination of dopamine [13], and arrays of cylindrical gold nanoelectrodes could be used for both the detection of dopamine and for the immobilization and growth of human neural cells [14].…”

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confidence: 99%

Electrochemical Aptasensor for Detection of Dopamine

et al. 2020

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This work presents a proof of concept of a novel, simple, and sensitive method of detection of dopamine, a neurotransmitter within the human brain. We propose a simple electrochemical method for the detection of dopamine using a dopamine-specific aptamer labeled with an electrochemically active ferrocene tag. Aptamers immobilized on the surface of gold screen-printed gold electrodes via thiol groups can change their secondary structure by wrapping around the target molecule. As a result, the ferrocene labels move closer to the electrode surface and subsequently increase the electron transfer. The cyclic voltammograms and impedance spectra recorded on electrodes in buffer solutions containing different concentration of dopamine showed, respectively, the increase in both the anodic and cathodic currents and decrease in the double layer resistance upon increasing the concentration of dopamine from 0.1 to 10 nM L −1 . The high affinity of aptamer-dopamine binding (KD ≈ 5 nM) was found by the analysis of the binding kinetics. The occurrence of aptamer-dopamine binding was directly confirmed with spectroscopic ellipsometry measurements.Chemosensors 2020, 8, 28 2 of 11 done on the electrochemical detection of dopamine and other neurotransmitters [2,3]. Dopamine can be very easily detected in an aqueous solution by electrochemical methods such as cyclic voltammetry since dopamine undergoes electrochemical oxidation. However, a major issue is the selectivity since complex matrices such as blood contain a range of other oxidizable compounds such as urate or ascorbate which would also generate signals, leading to inaccurate readings. Selectivity towards dopamine is therefore required.A wide range of electrode materials have been proposed to increase the selectivity of dopamine detection [2,3]. A few recent examples include the use of materials such as Nafion combined with graphite [4] or multi-walled carbon nanotubes [5] to improve the selectivity towards dopamine. Other researchers have utilized graphene-modified screen-printed electrodes [6] or graphene aerogels [7] as substrates for the selective determination of dopamine. Composites of carbon nanotubes and graphene oxide could be used to determine dopamine, nitrate, ascorbate, and urate [8]. Metal nanoparticles have also been utilized, for example palladium nanoparticles combined with graphene [9], which were used as a base of electrochemical determination of dopamine whereas a gold nanoparticle/DNA/polymer composite could be used for the simultaneous determination of dopamine, uric acid, guanine, and adenine [10]. Composites of gold nanoparticles with conducting polymers have also been used for the selective determination of dopamine [11]. Boron-doped carbon nanotubes could be used to determine levels of dopamine and ephedrine in the presence of urate [12]. Composites of graphene oxide with Bi 2 S 3 nanorods were used for the electrochemical determination of dopamine [13], and arrays of cylindrical gold nanoelectrodes could be used for both the detection of dopamine an...

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“…To that end, quantum dots [65,66], plasmonic nanoparticles [67][68][69][70], carbon nanotubes [71] and graphene [72] have been widely explored for the development of affinity-based nanoprobes to detect common narcotics [65,66], anabolic steroids [71], drugs with abuse potential [69], explosives [67,72] and pathogens that can potentially be linked to bioterrorism [68], as well as to determine time since death [70]. Moreover, wearable biosensors can monitor continuously and in real time adverse lifestyle habits associated with criminal behaviour, such as the excessive use of alcohol [73].…”

Section: Molecular Sensingmentioning

confidence: 99%

Carbon Dots for Forensic Applications: A Critical Review

Verhagen

Kelarakis

2020

Nanomaterials

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Owing to their superior fluorescence performance, inexpensive synthesis and nontoxic nature, carbon dots (C-dots) are systematically explored in a variety of applications; in this review, we outline and critically discuss recent trends with respect to their potential exploitation in criminal investigation, forensic toxicology and anti-counterfeit interventions. Capitalising on their colour-tuneable behaviour (in the sense that they adopt different colours with respect to the incident radiation), C-dot-based compositions are ideal for the visual enhancement of latent fingerprints, affording improved contrast against multicoloured and patterned backgrounds. As highly sensitive and highly selective optical nanoprobes, C-dots show excellent analytical performance in detecting biological compounds, drugs, explosives, heavy metals and poisonous reactants. In addition, benefiting from their versatile structural and chemical composition, C-dots can be incorporated into ink and polymeric formulations capable of functioning as a new generation of cost-effective barcodes and security nanotags for object authentication and anti-counterfeit applications. Translating these encouraging research outcomes into real-life innovations with significant social and economic impact requires an open, multidisciplinary approach and a close synergy between materials scientists, biologists, forensic investigators and digital engineers.

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Boron-doped multi-walled carbon nanotubes as sensing material for analysis of dopamine and epinephrine in presence of uric acid

Abstract: Boron-doped multi-walled carbon nanotubes as sensing material for analysis of dopamine and epinephrine in presence of uric acid

Cited by 28 publications

References 55 publications

Electrochemical Detection of Neurotransmitters

Electrochemical Detection of Neurotransmitters

Electrochemical Aptasensor for Detection of Dopamine

Carbon Dots for Forensic Applications: A Critical Review

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