Boron-Enriched Polyvinyl-Alcohol/Boric-Acid Nanoparticles for Boron Neutron Capture Therapy

Abstract

Background: Due to the noninvasive nature of boron neutron capture therapy (BNCT), it is considered a promising cancer treatment method. Aim: To investigate whether polyvinyl alcohol/boric acid crosslinked nanoparticles (PVA/BA NPs) are an efficient delivery system for BNCT. Materials & methods: PVA/BA NPs were synthesized and cocultured with brain and oral cancers cells for BNCT. Results: PVA/BA NPs had a boron-loading capacity of 7.83 ± 1.75 w/w%. They accumulated in brain and oral cancers cells at least threefold more than in fibroblasts and macrophages. The IC50 values of the brain and oral cancers cells were at least ninefold and sixfold lower than those of fibroblasts and macrophages, respectively. Conclusion: Theoretically, PVA/BA NPs target brain and oral cancers cells and could offer improved therapeutic outcomes of BNCT.

Ex Vivo and In Vivo Evaluation of Dodecaborate-Based Clusters Encapsulated in Ferumoxytol Nanoparticles

“…At a dose of 20 mg/kg, 1 @FMX localized in tissues ranging from 0 to 65 μg of B per gram of tissue, suggesting that encapsulation of dodecaborate-based compounds in a polymer matrix can potentially have favorable effects on the biodistribution results. More broadly, this work suggests the potential importance of noncovalent interaction between boron clusters and polymers stemming from nonelectrostatic interactions and points to new avenues for creating hybrid boron-cluster-based nanomaterials without covalent attachment. − …”

Recent Development of Radiofluorination of Boron Agents for Boron Neutron Capture Therapy of Tumor: Creation of 18F-Labeled C-F and B-F Linkages

“…Of the boron-containing agents reported so far, boronophenylalanine (BPA) and borocaptate sodium (BSH) are the two most commonly used boron agents for clinical treatment ( Figure 1 ). In addition, various boron agents have been developed in the past decades, including peptides [ 27 , 28 ], antibody-based delivery systems [ 29 , 30 ], boron compound conjugates [ 31 , 32 ], boron-containing nanoparticles [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ], boric acid [ 41 , 42 , 43 ], and decahydrodecaborate (GB-10) [ 44 , 45 ].…”

Fluorescent Boron Oxide Nanodisks as Biocompatible Multi-messenger Sensors for Ultrasensitive Ni2+ Detection

“…Boron is a light chemical element able to form covalent-bonded molecular networks with a wide variety of structures . Bulk boron has been industrially employed in many different areas, such as high-density fuels, , protective coatings, semiconductors, , microelectronics, and refractory materials. , Furthermore, both elemental boron and its compounds have found interesting biomedical applications, especially in neutron capture therapy for cancer treatment in the currently under development field of nanomedicine. − When going down to the nanometric scale, boron-based nanomaterials appear in a wide variety of forms: nanoribbons, nanotubes, , nanowires, and nanofibers, − and the recently discovered borospherene , and borophene , that are B-based analogues of fullerene and graphene, respectively, as well as quasi-spherical nanoparticles (NPs), both crystalline and amorphous. − Additionally, several B-containing nanocompounds have attracted great interest from researchers, such as the well-known hexagonal boron nitride (h-BN), rare-earth borides, Kondo topological insulators, , or recently synthesized boron oxide nanoparticles, which have been proposed as additives to enhance electrochemical, mechanical, and thermal properties in certain composite materials . Despite the large interest in exploring and understanding all of these B-based nanostructures, experimental investigations in boron nanoscience are still relatively limited as compared to theoretical studies (with the exception of h-BN) .…”