Boron exposure assessment using drinking water and urine in the North of Chile

Cortés, Sandra; Reynaga-Delgado, Eire; Sancha, Ana María; Ferreccio, Catterina

doi:10.1016/j.scitotenv.2011.08.073

Cited by 35 publications

(23 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Because of this reason, the physiological role of boron has been widely studied. Appropriate amount of boron has a beneficial effect on the growth and development of the bone [11][12][13][14][15], the proliferation and differentiation of blood cells [16], and the functions of the brain [17], while high-level boron was harmful [18,19]. However, to our knowledge, so far, no study has evaluated the effects of boron on brain development.…”

Section: Introductionmentioning

confidence: 99%

Effect of Boric Acid Supplementation on the Expression of BDNF in African Ostrich Chick Brain

Tang

Zheng

Xiao

et al. 2015

Biol Trace Elem Res

View full text Add to dashboard Cite

The degree of brain development can be expressed by the levels of brain brain-derived neurotrophic factor (BDNF). BDNF plays an irreplaceable role in the process of neuronal development, protection, and restoration. The aim of the present study was to evaluate the effects of boric acid supplementation in water on the ostrich chick neuronal development. One-day-old healthy animals were supplemented with boron in drinking water at various concentrations, and the potential effects of boric acid on brain development were tested by a series of experiments. The histological changes in brain were observed by hematoxylin and eosin (HE) staining and Nissl staining. Expression of BDNF was analyzed by immunohistochemistry, quantitative real-time PCR (QRT-PCR), and enzyme linked immunosorbent assay (ELISA). Apoptosis was evaluated with Dutp-biotin nick end labeling (TUNEL) reaction, and caspase-3 was detected with QRT-PCR. The results were as follows: (1) under the light microscope, the neuron structure was well developed with abundance of neurites and intact cell morphology when animals were fed with less than 160 mg/L of boric acid (groups II, III, IV). Adversely, when boric acid doses were higher than 320 mg/L(groups V, VI), the high-dose boric acid neuron structure was damaged with less neurites, particularly at 640 mg/L; (2) the quantity of BDNF expression in groups II, III, and IV was increased while it was decreased in groups V and VI when compared with that in group I; (3) TUNEL reaction and the caspase-3 mRNA level showed that the amount of cell apoptosis in group II, group III, and group IV were decreased, but increased in group V and group VI significantly. These results indicated that appropriate supplementation of boric acid, especially at 160 mg/L, could promote ostrich chicks' brain development by promoting the BDNF expression and reducing cell apoptosis. Conversely, high dose of boric acid particularly in 640 mg/L would damage the neuron structure of ostrich chick brain by inhibiting the BDNF expression and increasing cell apoptosis. Taken together, the 160 mg/L boric acid supplementation may be the optimal dose for the brain development of ostrich chicks.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of Boric Acid Supplementation on the Expression of BDNF in African Ostrich Chick Brain

Tang

Zheng

Xiao

et al. 2015

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…The first component study tests exposure to Boron in drinking water, food and urine. High levels of this element in tap water ranged from 0.22 to 11.3 mgL-1 while Boron in urine ranged from 0.45 to 17.4 mgL-1 (Cortés et al, 2011). Results no published on B in more frequently used foods shows values between 0.01 and 22 mgKg-1; according our data mean daily boron intake was principally due by drinking water (60 %).…”

Section: Introductionmentioning

confidence: 43%

High Exposure to Boron in Drinking Water and Sperm Parameters in Chilean Young People

2017

View full text Add to dashboard Cite

CORTÉS, S.; ESPINOZA-NAVARRO, O. & FERRECCIO, C.High exposure to boron in drinking water and sperm parameters in young Chilean people. Int. J. Morphol., 35(1):99-104, 2017. SUMMARY:Our aim was to describe sperm parameters in residents from Northern Chile. We evaluated in 101 volunteers (18 and 30 years old) urinary and drinking water Boron levels using Inductively Coupled Plasma Mass Spectrometry; semen parameters were measured with standardized methods. Each individual was categorized in 3 levels of exposure: low (B levels in urine ≤ 2.94 mgL-1 or tap water ≤ 3.0 mgL-1), medium (urinary B between 2.95-7.4 mgL-1 and B in tap water with 3.0-7.0 mgL-1) and high (urinary B > 7.4 mgL-1 or tap water > 7.0 mgL-1). We found no significant differences among groups by pH, sperm concentration (45.1; 48.2 and 38 million/mL), motility 1th hour (38.1; 40.0 and 45.5 %) and vitality 1th hour (88.6; 88.0 and 76.9 %) respectively. Abnormal morphology was significant different (83.3; 90 and 83 %). Young men exposed to B in drinking water present sperm variations associated with the level of exposure. Most of these changes are positive at intermediate levels of B. For the highest exposures were observed negative changes in sperm morphology, concentration, motility and vitality, all relevant parameters of fertility. Beneficial effect is observed at medium exposure, like a "U curve".

show abstract

“…The WHO guideline value for B in drinking water (0.5 mg L À1 ) is designated as provisional because of the difficulty in achieving it in areas of high natural B levels. The pertinence of this statement is exemplied in the work undertaken by Cortes et al 113 The researchers determined levels of B in tap and bottled water from a region of Northern Chile and corresponding levels of B in urine from a volunteer population drinking this water. Urine and water concentrations of B were determined using ICP-AES.…”

Section: View Article Onlinementioning

confidence: 99%

“…7.2.8 Drinking water and non-alcoholic beverages. Safe levels of B in drinking water are still open for question and work by Cortes et al 113 highlighted issues in northern Chile, an area naturally high in this element. This study represented the rst detailed assessment of B exposure in Chilean tap and bottled water (173 samples) analysed by ICP-AES, along with urine provided by volunteers (22 samples) over four years.…”

mentioning

confidence: 99%

Atomic spectrometry update. Clinical and biological materials, foods and beverages

Taylor

Branch

Day

et al. 2010

J. Anal. At. Spectrom.

View full text Add to dashboard Cite

Boron exposure assessment using drinking water and urine in the North of Chile

Cited by 35 publications

References 22 publications

Effect of Boric Acid Supplementation on the Expression of BDNF in African Ostrich Chick Brain

Effect of Boric Acid Supplementation on the Expression of BDNF in African Ostrich Chick Brain

High Exposure to Boron in Drinking Water and Sperm Parameters in Chilean Young People

Atomic spectrometry update. Clinical and biological materials, foods and beverages

Contact Info

Product

Resources

About