Boron neutron capture therapy (BNCT) in Finland: Technological and physical prospects after 20 years of experiences

Basic Principle Application and Technology of Boron Neutron Capture Cancer Therapy (BNCT) Utilizing Monte Carlo N Particle 5’S Software (MCNP 5) with Compact Neutron Generator (CNG)

“…That therapy not effective because just can increase patient viability as big as 75% up to a two year and trouble other organ functions, as fall of hair and healthy tissue damage (NCI,2009;Wahyuningsih, 2014). Operate is utilized on early phase therapy, where does tumor be still gets tame character (Abeloff and Martin, 2008 Savolainen, S., et al 2012;Helsinki, 2014). Specifically for therapy raising hell cancer as head and neck cancer(R. Gonza ´ lez Gonza ´ lez, et al 2012;Yu, Hui Ting., et al without year;Helsinki, 2014), prostate cancer (Yasui,L., et al 2012), oral cancer (Yura, Y.…”

Intracavitary moderator balloon combined with252Cf brachytherapy and boron neutron capture therapy, improving dosimetry in brain tumour and infiltrations

“…Additionally, owing to the higher cancer cell metabolism, the boron concentration is often lower in the normal tissue and blood but is higher in the tumour, promoting a selective absorbed dose effect. 5,6 BNCT is still considered experimental but has been under continuous development over the past few decades. [5][6][7] Clinical trials have been developed in various international centres, strengthening the applicability of this technique in medicine and confirming the safety of the method.…”

“…5,6 BNCT is still considered experimental but has been under continuous development over the past few decades. [5][6][7] Clinical trials have been developed in various international centres, strengthening the applicability of this technique in medicine and confirming the safety of the method. [8][9][10][11] One of the major difficulties in BNCT application is associated with neutron source generation required for brain irradiation.…”

“…A neutron was considered to emit 2.31434 3 10 12 n s 21 g 21 per 252 Cf mass. Thus, in the Cf-BNCT-LWB and Cf-BNCT-HWB in 5,16,33 However, the cure for glioblastoma still represents a challenge and involves the overall elimination of neoplastic cellular residues and infiltrations in the periphery of the resection region at the tumour bed. [34][35][36] Currently, the standard protocol for early diagnosed glioblastoma comprises tumour resection, followed by radiotherapy with concomitant or adjuvant chemotherapy, Cf brachytherapy.…”

“…However, reports on clinical attempts based on reactor technology have been continuously published in the past two decades, with encouraging results. 5,12,48,49 This article proposed a combination of 252 Cf brachytherapy, BNCT and an intracavitary balloon catheter, filled with a solution that slowed the neutrons emitted by a sealed source for the treatment of GBM. The results showed a dosimetric advantage in Cf-BNCT-HWB compared with Cf-BNCT because the dose in the infiltrations was approximately 60 times larger with HWB.…”