Boron-Neutron Capture Therapy vs. Photon Beam for Malignant Brain Tumours — 12 Years’ Experience

Hatanaka, Hiroshi; Amano, Kazuyoshi; Kamano, Shuji; Tovaryś, F; Machiyama, N.; Matsui, Takehisa; Fankhauser, Heinz; Hanamura, Tetsu; Nukada, Tadaatsu; Kurihara, Toshikazu; Ito, N.; Sano, Keiji

doi:10.1007/978-3-662-08801-2_15

Cited by 6 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the effectiveness of the following two irradiation techniques; (i) replacement by heavy water of a part of light water in the human body (deuteration) and (ii) formation of a void or a cavity in the surface part of the human head (void formation), which had been previously proposed (Hatanaka et al 1982), was confirmed by simulation calculations and phantom experiments. Technique (i) has been sometimes applied for actual clinical trials (Nakagawa et al 1993).…”

Section: Introductionsupporting

confidence: 60%

Studies on depth-dose-distribution controls by deuteration and void formation in boron neutron capture therapy

Sakurai

2004

Phys. Med. Biol.

View full text Add to dashboard Cite

Physical studies on (i) replacement of heavy water for body water (deuteration), and (ii) formation of a void in human body (void formation) were performed as control techniques for dose distribution in a human head under neutron capture therapy. Simulation calculations were performed for a human-head-size cylindrical phantom using a two-dimensional transport calculation code for mono-energetic incidences of higher-energy epi-thermal neutrons (1.2-10 keV), lower-energy epi-thermal neutrons (3.1-23 eV) and thermal neutrons (1 meV to 0.5 eV). The deuteration was confirmed to be effective both in thermal neutron incidence and in epi-thermal neutron incidence from the viewpoints of improvement of the thermal neutron flux distribution and elimination of the secondary gamma rays. For the void formation, a void was assumed to be 4 cm in diameter and 3 cm in depth at the surface part in this study. It was confirmed that the treatable depth was improved almost 2 cm for any incident neutron energy in the case of the 10 cm irradiation field diameter. It was made clear that the improvement effect was larger in isotropic incidence than in parallel incidence, in the case that an irradiation field size was delimited fitting into a void diameter.

show abstract

Section: Introductionsupporting

confidence: 60%

Studies on depth-dose-distribution controls by deuteration and void formation in boron neutron capture therapy

Sakurai

2004

Phys. Med. Biol.

View full text Add to dashboard Cite

show abstract

“…Thermal neutrons have hitherto been used for fundamental studies (Mishima et al 1976 and clinical trials (Hatanaka et al 1982(Hatanaka et al , 1983 of the neutron capture therapy. Fast neutrons have also been used in the treatment of cancer (Hussey et al 1974, Tsunemoto et al 1974, Tsunemoto 1982, Maruyama et al 1983.…”

Section: Introductionmentioning

confidence: 98%

The Contribution of the Nuclear Reaction¹H(n, γ)²D to the Yield of DNA Single Strand Breaks in Cultured Mammalian Cells Irradiated by Thermal Neutrons

Maki

Saito²,

Kawai

et al. 1985

International Journal of Radiation Biology and Related Studies

View full text Add to dashboard Cite

The yield of single strand breaks (ssb) in DNA of the HeLa S-3 cells after thermal neutron irradiation was examined using the alkaline sucrose gradient method. The contribution of the 1H(n, gamma)2D reaction to the yield of ssb was determined by substituting D2O for H2O in the irradiated medium. Calculation shows that when cells are irradiated in the H2O medium, the per cent contribution of the contaminating gamma-rays, the nuclear reaction 1H(n, gamma)2D and the other nuclear reactions is 31, 44 and 25 per cent respectively assuming additivity of effects. The estimated number of ssb induced by the nuclear reaction 1H(n, gamma)2D was at least 4.4 times greater than that by 60Co gamma-rays at the same absorbed dose. Two possible interpretations are discussed to explain the high efficiency of the 1H(n, gamma)2D reaction for ssb induction.

show abstract

“…Early trials were disappointing, in part, because inappropriate distribution of infused '0B-enriched borates led to necrosis of normal brain structures (8). Current clinical trials of BNCT with the sulfhydryl borane Na2B12HjjSH are encouraging (9).…”

mentioning

confidence: 99%

Whole-body irradiation of deuterated mice by the 10B(n, alpha)7Li reaction.

Slatkin¹,

Stoner²,

Gremme³

et al. 1983

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Specific pathogen-free mice, 8-12 wk of age, were supplied with either acidified tap water or acidified 30 atom % 2H20 in tap water. Thirteen days later, when body water deuterium was about 20 atom %, mice were irradiated either by neutrons or by x-rays after intraperitoneal injection of boric acid. Mortality from whole-body neutron-boron radiation, unlike mortality from whole-body x-radiation, was not lowered by such deuteration. Time intervals to death of neutron-irradiated mice were compatible with the gastrointestinal syndrome. Neither species nor numbers of colonic bacteria were measurably altered by deuteration alone. Because the toxic, nonlethal range of deuterium substitution for aqueous hydrogen in mammals is approximately 1/5th to 1/3rd, these results indicate that partial deuteration of human tissues would improve neutron capture therapy of deep tumors. Neutron penetration would be enhanced and damage to normal tissues from photons would be decreased. The number of deuterium recoils due to neutron capture by hydrogen would also be decreased.Slow neutrons are much more reactive with '0B than with the naturally occurring nuclides of mammalian tissue (1). Neutron therapy of boron-perfused tumors via the '0B(n,a)7Li reaction (2) was proposed in 1936 (3). The tumoricidal potency of boron neutron capture therapy (BNCT) is demonstrable in small mammals (4-6). Clinical BNCT was initiated in 1951 to treat radioresistant brain tumors (7). Early trials were disappointing, in part, because inappropriate distribution of infused '0B-enriched borates led to necrosis of normal brain structures (8). Current clinical trials of BNCT with the sulfhydryl borane Na2B12HjjSH are encouraging (9).The slow neutron dose to a deep tumor can be enhanced by increasing the energy of incident neutrons (10). Enhancement can also be achieved by partial deuteration of tissue water (ref. 11 and unpublished data), but such deuteration would be effective only if it did not lessen radiation damage by a and 7Li particles. H20 is radioprotective for photon radiation (12-14). The present study indicates that 2H20, in common with other radioprotective agents (15), does not affect radiation damage by densely ionizing particles.The range of isotopic substitution of deuterium for hydrogen in mammalian whole-body water that is toxic but not lethal is about 1/5th to 1/3rd (16). The experiments reported here assessed the effect of 1/5th deuteration of body water on the lethality of whole-body radiation from the neutron-boron reaction in Swiss albino mice of the Hale-Stoner strain (17). Deuterated and nondeuterated Hale-Stoner mice were also tested with whole body x-radiation. Mice of the CF-1, Simonsen Swiss albino, Fillinsdorf Swiss albino, and DBA/2 strains were used in previous photon radiation studies on the protective effect of 2H20 (12-14). The intent of our x-ray studies was to ascertain that Hale-Stoner mice are also amenable to protection from photon radiation by 2H20.To supplement the present study, the effect of 2H20 alone on t...

show abstract

Boron-Neutron Capture Therapy vs. Photon Beam for Malignant Brain Tumours — 12 Years’ Experience

Cited by 6 publications

References 23 publications

Studies on depth-dose-distribution controls by deuteration and void formation in boron neutron capture therapy

Studies on depth-dose-distribution controls by deuteration and void formation in boron neutron capture therapy

The Contribution of the Nuclear Reaction¹H(n, γ)²D to the Yield of DNA Single Strand Breaks in Cultured Mammalian Cells Irradiated by Thermal Neutrons

Whole-body irradiation of deuterated mice by the 10B(n, alpha)7Li reaction.

Contact Info

Product

Resources

About

Boron-Neutron Capture Therapy vs. Photon Beam for Malignant Brain Tumours — 12 Years’ Experience

Cited by 6 publications

References 23 publications

Studies on depth-dose-distribution controls by deuteration and void formation in boron neutron capture therapy

Studies on depth-dose-distribution controls by deuteration and void formation in boron neutron capture therapy

The Contribution of the Nuclear Reaction1H(n, γ)2D to the Yield of DNA Single Strand Breaks in Cultured Mammalian Cells Irradiated by Thermal Neutrons

Whole-body irradiation of deuterated mice by the 10B(n, alpha)7Li reaction.

Contact Info

Product

Resources

About

The Contribution of the Nuclear Reaction¹H(n, γ)²D to the Yield of DNA Single Strand Breaks in Cultured Mammalian Cells Irradiated by Thermal Neutrons