Boronic Acid Decorated Graphene Nano Flakes for Glucose Sensing in Diabetes: A DFT Prediction

Lakhera, Praveen; Singh, Sukhbir; Mehla, Ravi; Chaudhary, Vikas; Kumar, Parveen; Kumar, Sanjeev

doi:10.1109/jsen.2022.3158003

Cited by 12 publications

(5 citation statements)

References 19 publications

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“…On the side of electronic parameters (see Table 1), the energy gap obtained was 4.34 eV. This value is similar to that reported by Darwish et al., [45] and larger with respect to other graphene‐like systems [49] . Clearly, Gap LH decreases 0.45 eV with respect to its bare counterpart, nevertheless; the semiconductor‐like behavior is maintained.…”

Section: Resultssupporting

confidence: 86%

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Insights on α‐Glucose Biosensors/Carriers Based on Boron‐Nitride Nanomaterials from an Atomistic and Electronic Point of View

2022

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The interaction of α-glucose with a BN-nanosheet, BN-nanotube, and BN-fullerene, was analyzed from an atomistic and electronic point of view, to evaluate such nanostructures as possible carriers and/or biosensors of the α-glucose molecule. Adsorption energies are in the range of physisorption (À 0.79 eV to À 0.91 eV) for the BN-nanosheet and -nanotube, and chemisorption (À 2.24 eV to À 2.35 eV), for the BN-fullerene. All systems, exhibit semiconductor-like behavior and great stability according to j LUMO-HOMO j energy gap [Gap LH ] and chemical potential values, respectively. For the BN-nanosheet and -nanotube, the stabilization of the complexes is through hydrogen bonds, while for BN-fullerene is through a covalent bond and charge transfer. Furthermore, the BN-fullerene is able to dissociate the α-glucose molecule, which could help to decomposer such a compound, and be used for biological applications. The data taking into consideration solvent effects have no significant impact with respect to gas phase, except in the dipole moment (M d ) where we noticed an increase up to ~45 %. Our results suggest that BN-nanosheet and -nanotube, may act as biosensors, while BN-fullerene, may serve as a carrier or degrader of the α-glucose molecule.

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Section: Resultssupporting

confidence: 86%

“…This value is similar to that reported by Darwish et al, [45] and larger with respect to other graphene-like systems. [49] Clearly, Gap LH decreases 0.45 eV with respect to its bare counterpart, nevertheless; the semiconductor-like behavior is maintained. This decrement is associated with sensing glucose.…”

Section: Bnns-glucose Complex Analysismentioning

confidence: 94%

Insights on α‐Glucose Biosensors/Carriers Based on Boron‐Nitride Nanomaterials from an Atomistic and Electronic Point of View

2022

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“…The limitations of the traditional enzymatic glucose sensing using glucose oxidase are cost, length, instability, and proneness to denaturation of enzymes. BA derivatives have been reported as important binding agents for glucose and HbA1c sensing . The proposed electrochemical sensor in this work relies on the formation of a boronate ester complex between BA attached with ZIF-8 NPs and the cis -diol moieties of the glucose molecule.…”

Section: Resultsmentioning

confidence: 99%

Detection of Glycosylated Hemoglobin on Boronic Acid-Modified Zeolitic Imidazolate Framework-8 Nanoparticles

Lakhera,

Chaudhary,

Singh

et al. 2023

ACS Appl. Nano Mater.

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“…The absorbance of each Hb solution in the pH 6.0 buffer was measured using the UV−vis spectrophotometer at the established wavelength of 406 nm with the contribution of isosbestic point of Hb. 55 A second calibration line was constructed by plotting the absorbance values against the corresponding concentrations (mg/mL) of the Hb solutions in the pH 6.0 buffer (y = 0.1571x + 0.0019 (R 2 = 0.9987). These calibration lines serve as reference tools, establishing a quantitative relationship between absorbance values and the concentration of Hb solutions.…”

Section: Optimization Of Adsorption Conditions 221 Hb Calibration Linesmentioning

confidence: 99%

Selective Extraction and Quantification of Hemoglobin Based on a Novel Molecularly Imprinted Nanopolymeric Structure of Poly(acrylamide-vinyl imidazole)

Şarkaya,

Özçelik,

Yaşar

et al. 2024

ACS Omega

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Imbalances in hemoglobin (Hb) levels can lead to conditions such as anemia or polycythemia, emphasizing the importance of precise Hb extraction from blood. To address this, a novel synthetic imprinted polymer was meticulously developed for capturing and separating Hb. Poly(acrylamide-vinylimidazole) nanopolymer (poly(AAm-VIM)) was synthesized using acrylamide and vinyl imidazole as functional monomers through surfactant-free emulsion polymerization. Characterization using FTIR, particle size, zeta potential, and SEM ensured the polymer's structure. The Hb-imprinted nanopolymer (Hbpoly(AAm-VIM)) demonstrated notable specificity, with a calculated Hb-specific adsorption value (Q max ) of 3.7377 mg/g in a medium containing 2.5 mg/mL Hb. The molecularly imprinted polymer (MIP) exhibited approximately 5 times higher Hb adsorption than the nonimprinted polymer (NIP). Under the same conditions, the imprinted nanopolymer displayed 2.39 and 2.17 times greater selectivity for Hb over competing proteins such as bovine serum albumin (BSA) and lysozyme (Lys), respectively. Also, SDS-PAGE analysis results confirmed the purification of Hb by the molecularly imprinted nanopolymer. These results underscore the heightened specificity and efficacy of the molecularly imprinted nanopolymer in selectively targeting Hb atoms among other proteins. Incorporating such polymers is justified by their notable affinity, cost-effectiveness, and facile production. This research contributes valuable insights into optimizing synthetic imprinted polymers for efficient Hb extraction, with potential in medical diagnostics and treatment applications.

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Boronic Acid Decorated Graphene Nano Flakes for Glucose Sensing in Diabetes: A DFT Prediction

Cited by 12 publications

References 19 publications

Insights on α‐Glucose Biosensors/Carriers Based on Boron‐Nitride Nanomaterials from an Atomistic and Electronic Point of View

Insights on α‐Glucose Biosensors/Carriers Based on Boron‐Nitride Nanomaterials from an Atomistic and Electronic Point of View

Detection of Glycosylated Hemoglobin on Boronic Acid-Modified Zeolitic Imidazolate Framework-8 Nanoparticles

Selective Extraction and Quantification of Hemoglobin Based on a Novel Molecularly Imprinted Nanopolymeric Structure of Poly(acrylamide-vinyl imidazole)

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