“…[12][13][14][15] ZIF8 possesses extra-high porosity, chemical and thermal stability, biocompatibility, and easily controllable size and shape. [16][17][18] Multifunctional ZIF8 nanomaterials have adaptability and responsiveness to various endogenous stimuli (e.g., pH, enzyme, and redox gradients) [19][20][21][22][23][24][25] and exogenous stimuli (e.g., temperature, magnetic eld, and light) [26][27][28][29] and controllable drug release for disease therapy and cell imaging. 24,30 Additionally, ZIF8 nanocarriers can have various nanomedicine applications, such as targeting cancer cells with hyaluronic acid conjugates, 31 magnetic resonance and uorescence imaging using uorescein isothiocyanate (FITC), 19 and controlled drug release by graphene oxide.…”