2019
DOI: 10.1039/c9cs00184k
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Boronic acids as building blocks for the construction of therapeutically useful bioconjugates

Abstract: This review summarizes boronic acid's contribution to the development of bioconjugates with a particular focus on the molecular mechanisms underlying its role in the construction and function of the bioconjugate, namely as a bioconjugation warhead, as a payload and as part of a bioconjugate linker.

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Cited by 238 publications
(165 citation statements)
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References 193 publications
(247 reference statements)
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“…The compounds have been known for about 150 years, but increasing interest is observed after the discovery of new areas of their use. The most important fields are the synthesis of biaryl compounds in the Suzuki-Miyaura reaction (Nobel 2010) [5], the molecular receptors of sugars [6], covalent organic frameworks [7] and their use as biologically active compounds [8]. Such wide applications require recognition of the physicochemical properties of these compounds.…”
Section: Introductionmentioning
confidence: 99%
“…The compounds have been known for about 150 years, but increasing interest is observed after the discovery of new areas of their use. The most important fields are the synthesis of biaryl compounds in the Suzuki-Miyaura reaction (Nobel 2010) [5], the molecular receptors of sugars [6], covalent organic frameworks [7] and their use as biologically active compounds [8]. Such wide applications require recognition of the physicochemical properties of these compounds.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the hydrogels crosslinked by boronate esters are multi-responsive to pH, sugar, and other diol-containing molecules. In fact, boronate ester-based materials have been constructed and used in drug delivery, saccharide sensing, memory materials, and injectable materials [30][31][32][33][34]. However, the low stability of the boronic ester bond prevent their practical applications [27,35].…”
Section: Introductionmentioning
confidence: 99%
“… Stabilization of hydrolytically labile imine and hydrazone bonds through formation of iminoboronates ( 11 , 12 ) and diazaborine complexes ( 13 , 14 ) …”
Section: Exploiting the Hallmarks Of Cancer: Linker Cleavage Promotedmentioning
confidence: 99%