Borrelia-Associated Primary Cutaneous MALT Lymphoma in a Nonendemic Region

Fouchardière, Arnaud de la; Vandenesch, François; Berger, Françoise

doi:10.1097/00000478-200305000-00017

Cited by 55 publications

(51 citation statements)

References 11 publications

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“…The highest frequency was found in the MALT histotype (10%-42%), followed by follicular lymphoma (15%-20%) and diffuse large B-cell lymphoma (17%-33%). Moreover, Borrelia DNA was detected in 19% of 16 cases of primary cutaneous MALT lymphomas diagnosed in a nonendemic region of France [7]. These studies exhibited two major limitations: PCR amplicons were not sequenced to confirm Borrelia identity and the adopted PCR protocols were unable to discriminate among involved genospecies.…”

Section: Discussionmentioning

confidence: 99%

“…At variance with the literature, our study includes the largest series of cutaneous lymphoma ever tested so far for the Takino et al [20] 60 Taiwan-Japan (n ϭ 25) hbb MZL (n ϭ 60) 0 (0%) ND Germany (n ϭ 23) U.S. (n ϭ 12) Goteri et al [10] 73 Central Italy Bb-specific gene [21] FCL (n ϭ 33) 0 (0%) ND DLBCL (n ϭ 24) 0 (0%) MZL (n ϭ 16) 0 (0%) Li et al [11] 24 Taiwan hbb MZL (n ϭ 24) 0 (0%) ND de la Fouchardiere et al [7] 16 Another crucial and practical topic involves the importance of antibiotic therapy in lymphomas of the skin. Available data on treatment in our series clearly show that an antibiotic approach was not among our therapeutic choices (Table 1), but regression of cutaneous lymphoma after antibiotic therapy in a few anecdotal case reports represents a tempting argument, which corroborates a role for Borrelia in sustaining tumor growth (Table 2).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Borrelia Burgdorferi Infection in a Series of 98 Primary Cutaneous Lymphomas

Ponzoni

Ferreri²,

Mappa³

et al. 2011

The Oncologist

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Borrelia burgdorferi has been variably associated with different forms of primary cutaneous lymphoma. Differences in prevalence rates among reported studies could be a result of geographic variability or heterogeneity in the molecular approaches that have been employed. In the present study, we investigated the prevalence of Borrelia burgdorferi sensu lato DNA in diagnostic tissue samples from fresh cutaneous biopsies of 98 primary cutaneous lymphomas and 19 normal skin controls. Three different polymerase chain reaction (PCR) protocols targeting the hbb, flagellin, and Osp-A genes were used. Direct sequencing of both sense and antisense strands of purified PCR products confirmed the specificity of the amplified fragments. Sequence specificity was assessed using the Basic Local Alignment Search Tool, and MultAlin software was used to investigate the heterogeneity of target gene sequences across the different samples.Borrelia DNA was not detected in 19 controls, 23 cases of follicular lymphoma, 31 cases of extranodal marginal zone lymphoma, or 30 cases of mycosis fungoides. A single case of 14 diffuse large B-cell lymphoma cases was positive for B. burgdorferi.This study does not support a pathogenic role of B. burgdorferi in primary cutaneous B-and T-cell lymphomas from areas nonendemic for this microorganism and the consequent rationale for the adoption of antibiotic therapy in these patients. The Oncologist 2011;16:1582-1588

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of Borrelia Burgdorferi Infection in a Series of 98 Primary Cutaneous Lymphomas

Ponzoni

Ferreri²,

Mappa³

et al. 2011

The Oncologist

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“…29 Interestingly, a French series (nonendemic region) found Borrelia DNA in 19% of 16 cases with primary cutaneous MALT lymphoma. 30 Antibiotic therapy for B burgdorferi in cutaneous MALT lymphoma (also formerly referred to as "skin-associated lymphoid tissue" lymphoma) has been described in 4 case reports 31-34 comprising a total of 5 patients. Interestingly, in an additional case report, amplified DNA of B afzelii was found.…”

Section: Cutaneous Malt Lymphomamentioning

confidence: 99%

“…32 In the French series described previously, 1 of the 3 detected Borrelia-associated cutaneous MALT lymphomas responded to antibiotic treatment, but no further clinical data on follow-up were available. 30 In the context of antibiotic therapy in cutaneous MALT lymphoma, it has to be mentioned that a series published in 1991 has reported on 4 patients with cutaneous lymphomas given anitibiotic therapy. 36 Although one may speculate that these might indeed have been MALT lymphomas, a definite diagnosis according to accepted pathohistologic criteria cannot be extracted from this paper.…”

Section: Cutaneous Malt Lymphomamentioning

confidence: 99%

Antibiotic therapy in nongastrointestinal MALT lymphoma: a review of the literature

Kiesewetter

Raderer

2013

Blood

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Although antibiotic therapy has been established as the standard of care in patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma, much less is known about the value of antibiotic therapy in nongastrointestinal (non-GI) MALT lymphomas. A computerized search (Medline) accompanied by a manual search to identify clinical reports on the topic of antibacterial therapy in patients with non-GI MALT lymphomas was performed. The majority of data were available for MALT lymphoma of the ocular adnexa (OAML) including a total of 131 patients in 4 retrospective studies, 3 prospective series (including 81 patients), and 1 case report. Treatment was exclusively targeting Chlamydophila psittaci (CP), using doxycycline in all but 2 studies. The median follow-up for these studies was 25 months, and both CP-positive as well as CP-negative patients responded. Complete remission was achieved in 23 patients (18%), 36 (27%) had a partial remission, 55 (42%) had stable disease, and 8 patients (6%) had progressive disease accounting for an overall response rate of 45%. In the largest study, a better response was suggested in CP-positive patients. By contrast, only scattered reports could be found for other non-GI localizations, allowing no conclusion about the benefit of antibiotic therapy and probably resulting in a publication bias toward positive cases. Based on these results, antibiotic therapy using doxycycline appears to be a reasonable first-line therapy for patients with OAML. Antibiotics, however, remain experimental for the time being in patients with other non-GI MALT lymphomas. Further preclinical studies as well as large-scale therapeutic trials are warranted to define the role of antibiotic therapy in such patients.

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“…PCBCLs also appear to differ from other MALT lymphomas in other ways: they tend to produce switched immunoglobulins that lack rheumatoid factor reactivity, they do not express CXCR3, and they produce a cytokine profile that appears biased toward the Th2 type of cellular response (253). Unlike gastric MALT lymphoma, only a few cases of PCBCL have responded to antibiotics (42,57,91,141,166,206). As in the case of C. psittaci and ocular adnexal MALT lymphoma, if B. burgdorferi is truly associated with PCBCL, then there is wide geographic variability and other factors are probably involved.…”

Section: Antigen-driven Lymphoproliferationmentioning

confidence: 99%

Role of Bacteria in Oncogenesis

2010

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SUMMARY Although scientific knowledge in viral oncology has exploded in the 20th century, the role of bacteria as mediators of oncogenesis has been less well elucidated. Understanding bacterial carcinogenesis has become increasingly important as a possible means of cancer prevention. This review summarizes clinical, epidemiological, and experimental evidence as well as possible mechanisms of bacterial induction of or protection from malignancy.

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Borrelia-Associated Primary Cutaneous MALT Lymphoma in a Nonendemic Region

Cited by 55 publications

References 11 publications

Prevalence of Borrelia Burgdorferi Infection in a Series of 98 Primary Cutaneous Lymphomas

Prevalence of Borrelia Burgdorferi Infection in a Series of 98 Primary Cutaneous Lymphomas

Antibiotic therapy in nongastrointestinal MALT lymphoma: a review of the literature

Role of Bacteria in Oncogenesis

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