Borrelial Lymphocytoma in Children

Arnež, Maja; Ružić‐Sabljić, Eva

doi:10.1097/inf.0000000000000884

Cited by 15 publications

(16 citation statements)

References 14 publications

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“…Our results in 144 consecutive adult patients with BL diagnosed in a single center during a period of 29 years showed that most of the pretreatment clinical characteristics were similar to those in previous reports. All our patients had solitary BL, which is not surprising given that after the recognition of LB only 2 cases of multiple BL lesions, both in children, have been reported [20,34]. BL was located on the breast in 106 of our 144 patients (73.6%), on the ear lobe in 27 (18.8%), and at other locations in 11 (7.6%), substantiating previous findings that in adults BL is predominantly localized on the breast in the region of the areola mammae.…”

Section: Treatment Resultsmentioning

confidence: 97%

“…Thus, in the 29-year period of the present study, EM was diagnosed in >16 000 adult patients but BL in only 144 at our LB Outpatient Clinic, which equates to about 550 and 5 cases per year, respectively. At the same institution, 33 children <15 years old were identified with BL in a period of 7 years (2008-2014), which is also about 5 cases per year [34]; however, this age group represents <15% of the Slovenian population.…”

Section: Treatment Resultsmentioning

confidence: 99%

“…All patients with treatment failure had uneventful outcome after retreatment. [18][19][20][21][22][23][24][25] than in adults [26][27][28][29][30][31][32], and 6 reports consisting of ≥20 cases of BL, 2 of which included only children [33,34], 3 included children and adults [2,7,8], and 1 included only adult patients [9]. Our results in 144 consecutive adult patients with BL diagnosed in a single center during a period of 29 years showed that most of the pretreatment clinical characteristics were similar to those in previous reports.…”

Section: Treatment Resultsmentioning

confidence: 99%

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Borrelial Lymphocytoma in Adult Patients

et al. 2016

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Background. Information on the course and outcome of borrelial lymphocytoma (BL) is limited. Methods. The study comprised 144 adult patients (75 female, 69 male; median age, 49 years) who had BL diagnosed at a single center between 1986 and 2014 and were followed up for 1 year.Results. BL was located on the breast in 106 patients (73.6%), on the ear lobe in 27 (18.8%), and elsewhere in 11 (7.6%). The median duration of BL before diagnosis was 27 days (interquartile range [IQR], 9-68 days). Concomitant erythema migrans was registered in 104 of 144 patients (72.2%); other objective manifestations of Lyme borreliosis (LB) were present in 11 (7.6%). Immunoglobulin M and/or G borrelial serum antibodies were present in 72 patients (50%). Borreliae were isolated from BL lesions in 14 of 42 patients (33.3%) who had not received antibiotics before skin biopsy. Of 13 typed Borrelia strains, 11 were B. afzelii, 1 was B. garinii, and 1 was B. bissettii. The median duration of BL after starting antibiotic treatment was 21 days ([IQR], 10-30 days); the average duration was longer in patients who were older, had longer BL duration before treatment, or had signs of disseminated LB. Treatment failure occurred in 14 of 144 patients (9.7%). Patients with signs or symptoms of disseminated LB before treatment had nearly 4 times higher odds of treatment failure (95% confidence interval, 1.22-13.07) than those without such symptoms. All patients with treatment failure had uneventful outcome after retreatment.Conclusions. BL is a rare manifestation of early localized LB. Fourteen-day antibiotic treatment, as used for erythema migrans, is effective.

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Section: Treatment Resultsmentioning

confidence: 97%

Section: Treatment Resultsmentioning

confidence: 99%

Section: Treatment Resultsmentioning

confidence: 99%

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Borrelial Lymphocytoma in Adult Patients

et al. 2016

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“…Borrelial lymphocytoma is a rare skin manifestation characterized by a painless bluish-red nodule, which is predominantly reported in children 82. Typically, borrelial lymphocytoma is localized on the ear lobe, nipple, or scrotum.…”

Section: Clinical Manifestations and Diagnosismentioning

confidence: 99%

Lyme borreliosis: diagnosis and management

Kullberg

Vrijmoeth

Schoor

et al. 2020

BMJ

113

118

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Lyme borreliosis is the most common vectorborne disease in the northern hemisphere. It usually begins with erythema migrans; early disseminated infection particularly causes multiple erythema migrans or neurologic disease, and late manifestations predominantly include arthritis in North America, and acrodermatitis chronica atrophicans (ACA) in Europe. Diagnosis of Lyme borreliosis is based on characteristic clinical signs and symptoms, complemented by serological confirmation of infection once an antibody response has been mounted. Manifestations usually respond to appropriate antibiotic regimens, but the disease can be followed by sequelae, such as immune arthritis or residual damage to affected tissues. A subset of individuals reports persistent symptoms, including fatigue, pain, arthralgia, and neurocognitive symptoms, which in some people are severe enough to fulfil the criteria for post-treatment Lyme disease syndrome. The reported prevalence of such persistent symptoms following antimicrobial treatment varies considerably, and its pathophysiology is unclear. Persistent active infection in humans has not been identified as a cause of this syndrome, and randomized treatment trials have invariably failed to show any benefit of prolonged antibiotic treatment. For prevention of Lyme borreliosis, post-exposure prophylaxis may be indicated in specific cases, and novel vaccine strategies are under development.

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“…In the case of borrelial lymphocytoma, a substantial increase in the number of IgG antibodies can be detected in the serum regardless of the length of infection [ 65 ], [ 76 ]. In rare cases, multiple borrelial lymphocytomas can occur in the early disseminated stages or even in the late stages of the disease.…”

Section: Clinical Manifestations Of Lyme Borreliosismentioning

confidence: 99%