Bosentan Affects 15-F2t-isoprostane Adverse Effects on Postischemic Rat Hearts

Liu, Huimin; Liu, Ke-Xuan; Cheng, Ming; Liu, Yanan; Lei, Shaoqing; Irwin, Michael G.; Xia, Zhengyuan

doi:10.1016/j.jss.2009.07.029

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…In contrast, ET-1 levels remained elevated at least 24 hours after cardiopulmonary bypass in patients [ 36 ]. The postischemic myocardial IS was assessed 60 min after reperfusion with concomitant measures of LV diastolic performance [ 38 ]. It should be noted that although Langendorff method is an ideal experimental model utilized to assess cardiac function and metabolism ex vivo , the measurement of right ventricular function which contributed to overall cardiac function is not assessed that causes some limitations in this study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts

Yao

Tao

et al. 2015

Journal of Diabetes Research

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The anesthetic propofol confers cardioprotection against myocardial ischemia-reperfusion injury (IRI) by reducing reactive oxygen species (ROS). However, its cardioprotection on patients is inconsistent. Similarly, the beneficial effect of tight glycemic control during cardiac surgery in patients has recently been questioned. We postulated that low glucose (LG) may promote ROS formation through enhancing fatty acid (FA) oxidation and unmask propofol cardioprotection during IRI. Rat hearts were isolated and randomly assigned to be perfused with Krebs-Henseleit solution with glucose at 5.5 mM (LG) or 8 mM (G) in the absence or presence of propofol (5 μg/mL) or propofol plus trimetazidine (TMZ). Hearts were subjected to 35 minutes of ischemia followed by 60 minutes of reperfusion. Myocardial infarct size (IS) and cardiac CK-MB were significantly higher in LG than in G group (P < 0.05), associated with reduced left ventricular developed pressure and increases in postischemic cardiac contracture. Cardiac 15-F2t-isoprostane was higher, accompanied with higher cardiac lipid transporter CD36 protein expression in LG. Propofol reduced IS, improved cardiac function, and reduced CD36 in G but not in LG. TMZ facilitated propofol cardioprotection in LG. Therefore, isolated heart with low glucose lost sensitivity to propofol treatment through enhancing FA oxidation and TMZ supplementation restored the sensitivity to propofol.

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Section: Discussionmentioning

confidence: 99%

Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts

Yao

Tao

et al. 2015

Journal of Diabetes Research

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“…Myocardial I/R injury can lead to oxidative stress in both the experimental settings of myocardial I/R (Xia et al, 2003a;Xia et al, 2003b;Zhengyuan et al, 2005;Liu et al, 2011) (Ansley et al, 2003;Xia et al, 2006;Huang et al, 2011). Varga et al, (2014 reported that miR-503 was downregulated in the isolated rat hearts subjected to 30 min of left anterior descending coronary artery ligation followed by 120 min of reperfusion, and ischemic postconditioning attenuated the downregulation of miR-503.…”

Section: Roles Of Mir-503 In Oxidative Stressmentioning

confidence: 99%

The Causes and Consequences of miR-503 Dysregulation and Its Impact on Cardiovascular Disease and Cancer

Cai

Pai

et al. 2021

Front. Pharmacol.

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microRNAs (miRs) are short, non-coding RNAs that regulate gene expression by mRNA degradation or translational repression. Accumulated studies have demonstrated that miRs participate in various biological processes including cell differentiation, proliferation, apoptosis, metabolism and development, and the dysregulation of miRs expression are involved in different human diseases, such as neurological, cardiovascular disease and cancer. microRNA-503 (miR-503), one member of miR-16 family, has been studied widely in cardiovascular disease and cancer. In this review, we summarize and discuss the studies of miR-503 in vitro and in vivo, and how miR-503 regulates gene expression from different aspects of pathological processes of diseases, including carcinogenesis, angiogenesis, tissue fibrosis and oxidative stress; We will also discuss the mechanisms of dysregulation of miR-503, and whether miR-503 could be applied as a diagnostic marker or therapeutic target in cardiovascular disease or cancer.

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Application of medical and analytical methods in Lyme borreliosis monitoring

2011

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Lyme borreliosis (LB) is one of the most common tick-borne diseases in the northern hemisphere. It is a chronic inflammatory disease caused by the spirochaete Borrelia burgdorferi. In its early stages, pathological skin lesions, namely erythema chronicum migrans, appear. The lesions, usually localised at the site of the bite, may become visible from a few weeks up to 3 months after the infection. Predominant clinical symptoms of the disease also involve joint malfunctions and neurological or cardiac disorders. Lyme disease, in all its stages, may be successfully treated with antibiotics. The best results, however, are obtained in its early stages. In order to diagnose the disease, numerous medical or laboratory techniques have been developed. They are applied to confirm the presence of intact spirochaetes or spirochaete components such as DNA or proteins in tick vectors, reservoir hosts or patients. The methods used for the determination of LB biomarkers have also been reviewed. These biomarkers are formed during the lipid peroxidation process. The formation of peroxidation products generated by human organisms is directly associated with oxidative stress. Apart from aldehydes (malondialdehyde and 4-hydroxy-2-nonenal), many other unsaturated components such as isoprostenes and neuroprostane are obtained. The fast determination of these compounds in encephalic fluid, urine or plasma, especially in early stages of the disease, enables its treatment. Various analytical techniques which allow the determination of the aforementioned biomarkers have been reported. These include spectrophotometry as well as liquid and gas chromatography. The analytical procedure also requires the application of a derivatization step by the use of selected reagents.

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Bosentan Affects 15-F2t-isoprostane Adverse Effects on Postischemic Rat Hearts

Cited by 4 publications

References 42 publications

Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts

Effects of Glucose Concentration on Propofol Cardioprotection against Myocardial Ischemia Reperfusion Injury in Isolated Rat Hearts

The Causes and Consequences of miR-503 Dysregulation and Its Impact on Cardiovascular Disease and Cancer

Application of medical and analytical methods in Lyme borreliosis monitoring

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