Boswellia serrata Extract Containing 30% 3-Acetyl-11-Keto-Boswellic Acid Attenuates Inflammatory Mediators and Preserves Extracellular Matrix in Collagen-Induced Arthritis

Majeed, Muhammed; Nagabhushanam, Kalyanam; Lawrence, Lincy; Nallathambi, Rameshprabu; Thiyagarajan, Varadharajan; Mundkur, Lakshmi

doi:10.3389/fphys.2021.735247

Cited by 22 publications

(14 citation statements)

References 37 publications

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“…Furthermore, the matrix proteins were also shown to be preserved via the enhanced hyaluronan levels in synovial fluid. The levels of phosphorylated-NF-κB (P65) were also reduced, coupled with the inhibition of enzymes such as collagenase, elastase, and hyaluronidase enzymes [ 105 ].…”

Section: Efficacy and Mechanism Of Action Of Polyphenolsmentioning

confidence: 99%

“…Boswellia treatment improved bone architecture and articular cartilage with open joint space in collagen-induced arthritis in rats [ 105 ].…”

Section: Tablementioning

confidence: 99%

“…Boswellia ↓serum CRP protein [ 102 ] ↑ mRNA levels of Runx2; activated the GSK-3β/β-catenin signaling pathway [ 104 ] ↓ NO synthase; ↓TNF-α, IL-6, and COX-2; ↑ hyaluronan levels in synovial fluid; ↓ phosphorylated-NF-κB (P65); inhibition of collagenase, elastase, hyaluronidase enzymes [ 105 ] …”

Section: Tablementioning

confidence: 99%

“…↓ NO synthase; ↓TNF-α, IL-6, and COX-2; ↑ hyaluronan levels in synovial fluid; ↓ phosphorylated-NF-κB (P65); inhibition of collagenase, elastase, hyaluronidase enzymes [ 105 ]…”

Section: Tablementioning

confidence: 99%

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Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

Sirše

2022

Life

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Osteoarthritis is a common crippling and degenerative disease resulting in irreversible functional changes due to damage of the cartilage and other tissues of the joint. With limited safe and effective pharmaceutical treatments, the demand and use for alternative therapeutic approaches with symptomatic relief for OA patients have increased. Clinical, pre-clinical, and in vitro studies have demonstrated that polyphenols can exert pain-relieving symptoms coupled with increased functional capacity in OA models. This review will highlight studies carried out in the last five years to define the efficacies and underlying mechanisms in polyphenols such as quercetin, resveratrol, curcumin, epigallocatechin-3-gallate, rosmarinic acid, genistein, ginger, berries, silver fir, pine bark, and Boswellia. Most of these studies indicate that polyphenols exhibit their beneficial roles through regulating changes at the biochemical and molecular levels, inducing or inhibiting various signaling pathways related to inflammation and oxidative stress. Polyphenols have also been implicated in modulating microRNA at the posttranscriptional level to counteract OA pathogenesis.

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Section: Efficacy and Mechanism Of Action Of Polyphenolsmentioning

confidence: 99%

“…Boswellia treatment improved bone architecture and articular cartilage with open joint space in collagen-induced arthritis in rats [ 105 ].…”

Section: Tablementioning

confidence: 99%

Section: Tablementioning

confidence: 99%

“…↓ NO synthase; ↓TNF-α, IL-6, and COX-2; ↑ hyaluronan levels in synovial fluid; ↓ phosphorylated-NF-κB (P65); inhibition of collagenase, elastase, hyaluronidase enzymes [ 105 ]…”

Section: Tablementioning

confidence: 99%

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Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

Sirše

2022

Life

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“…The antioxidant, anti-inflammatory and immunomodulatory effects of GR and BA have been confirmed in several articles (Baram et al 2019 ; Eltahir et al 2020 ; Efferth and Oesch 2020 ; Murck 2020 ; Gomaa and Abdel-Wadood 2021 , Gomaa et al 2021 ; Sun et al 2021 ; Renda et al 2021 ; Zheng et al 2021 , Zhang et al 2021b ). Moreover, GR and BA have strong inhibitory effect against NLRP3 inflammasome and NF-κB3 (Beghelli et al 2017 ; Roy et al 2019 ; Ding et al 2020 ; Majeed et al 2021 ). In addition, glycyrrhizin showed a greater ability than salicylic acid to inhibit high-mobility group box 1 protein (HMGB1) and suppress human GAPDH (HsGAPDH) translocation to the nucleus.…”

Section: Discussionmentioning

confidence: 99%

Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial

et al. 2022

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Recent evidence points to a potential therapeutic role for glycyrrhizin(GR) and boswellic acids (BA) in the treatment of COVID-19 but conclusive evidence is lacking. Our aim is to investigate the efficacy of GR + BA versus placebo for the treatment of hospitalized patients with moderate SARS-CoV-2 or COVID-19 variants infection. The current study is a randomized, double-blind, placebo-controlled, single-center trial. Patients with SARS-CoV-2 or COVID-19 variants diagnosed by PCR test who were admitted to Sohag University hospital were eligible if they were at least 18 years of age and had moderate symptoms. Patients were randomly assigned to receive oral GR capsule (60 mg) and BA (200 mg) twice daily for 14 days or a matching placebo. All patients also received treatment with the institutional protocol for COVID-19. The primary outcome was mortality and time to recovery. Secondary outcome was clinical status score, 14 days after receiving study drugs. Adverse events from use of study drugs have been evaluated for up to 14 days. The trial is registered at ClinicalTrials.gov (Identifier NCT04487964). During the 6-month enrollment period (June-November, 2021) only 50 patients (54% women; median age 60 years, IQR 54–65) met eligibility and were randomly assigned. Evaluation of the primary outcome at 14 days showed that there were five deaths in the placebo group and no deaths in the GR + BA group. With regard to recovery time, it was significantly shorter (p = 0.0001) in the group receiving GR + BA capsule compared to the placebo group (median 7.0; IQR 6.0–8.0 days vs. median 12.5; IQR 12–20 days). Clinical status on the ordinal score scale as a secondary outcome showed a significant difference between the GR + BA group (median (IQR) score, 2 [2–3]) and placebo groups (mean (IQR) score, 3 [3–5.5]). There was a significant decrease in CRB (p = 0.000041) in GR + BA compared with the placebo group. In conclusion, this safe, inexpensive, antiviral, immunomodulating and anti-inflammatory combination may be considered for use in mild to moderate infections of SARS-CoV-2 or COVID-19 variants. The study is limited by the small sample size; therefore, larger randomized trials are required.

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Ayurveda

Sodhi,

Sodhi

2023

Integrative Veterinary Medicine

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Boswellia serrata Extract Containing 30% 3-Acetyl-11-Keto-Boswellic Acid Attenuates Inflammatory Mediators and Preserves Extracellular Matrix in Collagen-Induced Arthritis

Cited by 22 publications

References 37 publications

Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial

Ayurveda

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