Botanical Medicine and Phytochemicals in Healthy Aging and Longevity—Part 1

Lucius, Khara

doi:10.1089/act.2019.29260.klu

Cited by 3 publications

(2 citation statements)

References 66 publications

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“…Healthy Aging: Including plenty of vegetables in the diet is associated with healthy aging and longevity. The nutrients and phytochemicals found in vegetables support cellular health, DNA repair, and overall vitality, contributing to a higher quality of life in older adults [26].…”

Section: Antioxidants: Many Vegetables Containmentioning

confidence: 99%

The Role of Bio-fortification in Enhancing the Nutritional Quality of Vegetables: A Review

Nagar,

Thakur,

Goutam

et al. 2024

AIR

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Bio-fortification is a process that enhances the nutritional quality of crops, including vegetables, by increasing their micronutrient content. It can be achieved through different approaches such as agronomic, conventional breeding, and transgenic/biotechnological methods. Vegetables are known to be rich in micronutrients, vitamins, antioxidants, and other health-benefiting compounds, making them essential for a balanced diet. However, malnutrition and hidden hunger continue to be global challenges, particularly in developing countries. Micronutrient deficiencies, such as iron, zinc, iodine, and vitamin A, are prevalent in these populations. Conventional breeding focuses on selecting genotypes with desirable nutritional traits without compromising agricultural productivity. Transgenic/biotechnological approaches involve the synthesis of transgenes to enhance the bioavailability of micronutrients in plants. Bio-fortification of vegetables is particularly important as they are rich sources of micronutrients, vitamins, and other health-benefiting compounds. However, improving the nutritional quality of vegetables through conventional breeding has had limited success, and modern molecular tools and techniques offer potential for handling complex traits and developing nutrient-dense varieties. Bio-fortification offers a sustainable solution to address these deficiencies by increasing the nutrient content of crops, particularly plant-based foods. These techniques have shown promising results in increasing the concentration of nutrients, such as iron, in vegetables, thereby improving their nutritional quality.

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Section: Antioxidants: Many Vegetables Containmentioning

confidence: 99%

The Role of Bio-fortification in Enhancing the Nutritional Quality of Vegetables: A Review

Nagar,

Thakur,

Goutam

et al. 2024

AIR

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“…This is partly due to increased environmental concerns and the adoption of vegan diets by consumers. At the same time, several studies have demonstrated the beneficial effects of botanical phenolic compounds to delay or even prevent age-associated deterioration of skin appearance and function [3,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Skin Anti-Aging Efficacy of a Four-Botanical Blend Dietary Ingredient: A Randomized, Double Blind, Clinical Study

Nobile¹,

Schiano²,

Germani³

et al. 2023

Cosmetics

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Plant polyphenols have been found to be effective in preventing or reducing different skin alterations. A dietary approach based on these compounds could be a safe and effective method to slow down or prevent age-associated deterioration of skin appearance and function. In a previous study, a specific combination of four botanical extracts (pomegranate, sweet orange, herba Cistanche, and Centella asiatica) exhibited potential anti-aging effects in a dermal fibroblast cell model. The present study aims to clinically evaluate the safety and anti-aging efficacy of this new botanical ingredient (eternalyoung®). To this end, a 12-week randomized, double-blind, placebo-controlled study was carried out in 60 Caucasian women with evident signs of both chrono- and photoaging. Product efficacy was measured as follows: skin moisturization (corneometer), transepidermal water loss (tewameter), skin radiance, and color (spectrophotometer), skin elasticity and firmness (cutometer), skin roughness (image analysis), and skin thickness (ultrasound). Both intergroup and intragroup analysis proved that the daily intake of 225 mg of the active ingredient was enough to produce visible and structural improvements to the skin and to the signs of aging without any side effects. Statistically significant improvements compared to the placebo group were observed as early as 4 weeks regarding wrinkle depth, elasticity, firmness, skin thickness, skin moisturization, transepidermal water loss, and dark spots pigmentation. In addition, the subjects who consumed the blend reported better scores on the self-assessment questionnaires. Our results suggest that the intake of the test product can positively affect the appearance, barrier function, and skin density of aged skin after 12 weeks of treatment.

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Skin and Scalp Health Benefits of a Specific Botanical Extract Blend: Results from a Double-Blind Placebo-Controlled Study in Urban Outdoor Workers

Nobile,

Cestone,

Ghirlanda

et al. 2024

Cosmetics

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Environmental pollution is increasingly recognized as a significant contributor to skin and scalp damage. Oral supplementation with a specific blend of four standardized botanical extracts (Rosmarinus officinalis, Lippia citriodora, Olea europaea leaf, and Sophora japonica) has been previously demonstrated to enhance skin health in individuals exposed to high environmental stress. Thus, it might represent a convenient strategy to also improve their scalp health aspect, particularly in subjects with sensitive scalps. To support these effects, a 12-week double-blind, randomized, placebo-controlled trial was performed in 66 women working outdoors in urban areas with high particulate matter (PM) levels and taking 250 mg of the botanical blend daily. Product efficacy was measured as follows: skin antioxidant status (FRAP); skin and scalp moisturization (corneometer), transepidermal water loss (tewameter), and oiliness (sebumeter); skin radiance and colour (spectrophotometer), elasticity and firmness (cutometer) and wrinkle depth (image analysis); and scalp clinical evaluation. Despite constant exposure to increased levels of PM, the tested product positively influenced all monitored parameters compared to both baseline and the placebo-treated group, in as early as 4 weeks. At the end of the study, key improvements included increased skin FRAP (21.9%), moisturization (9.5%), radiance (24.9%) and reduced wrinkle depth (−16.5%), dark spot pigmentation (−26.2%), and skin oiliness (−19.3%). For the scalp, moisturization increased (14.1%), TEWL decreased (−13.8%), and sebum content reduced by 16.2%. Additionally, 71% of subjects with sensitive scalps experienced reduced redness. These findings highlight the extensive benefits of the ingredient, expanding its application beyond conventional skin treatments to also alleviate scalp issues.

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Botanical Medicine and Phytochemicals in Healthy Aging and Longevity—Part 1

Cited by 3 publications

References 66 publications

The Role of Bio-fortification in Enhancing the Nutritional Quality of Vegetables: A Review

The Role of Bio-fortification in Enhancing the Nutritional Quality of Vegetables: A Review

Skin Anti-Aging Efficacy of a Four-Botanical Blend Dietary Ingredient: A Randomized, Double Blind, Clinical Study

Skin and Scalp Health Benefits of a Specific Botanical Extract Blend: Results from a Double-Blind Placebo-Controlled Study in Urban Outdoor Workers

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