Botanical Treatment and Prevention of Malaria: <i>Part 2—Selected Botanicals</i>

Yarnell, Eric; Abascal, Kathy

doi:10.1089/act.2004.10.277

Cited by 14 publications

(10 citation statements)

References 39 publications

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“…9 That article discussed a study showing that a tea of one of those plants-Artemisia annua (sweet Annie), might, safely and inexpensively, serve well as part of treatment for malaria. Instead, isolated artemisinin was pursued.…”

Section: Using Plants To Overcome Resistancementioning

confidence: 99%

“…9 However, the World Health Organization recently reported that "there is concern over the emergence and possible spread of Plasmodium falciparum resistance to artemisinins." 10 Whether a compound is plant-derived or synthetic, microbes learn very quickly how to overcome isolated constituents but are much less able to cope with the variety and complexity of compounds found in whole plants.…”

Section: Using Plants To Overcome Resistancementioning

confidence: 99%

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Plants for Addressing Multidrug Resistance: An Update

AbascalKathy

Yarnell

2013

Alternative and Complementary Therapies

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Plants, with their complex variety of compounds, are likely to hold at least part of the answer to our ever-increasing problem of multidrug resistant microbes. This article provides useful information for practitioners so that they can counsel patients who are taking antibiotics. Coverage includes how to enhance the ability of these drugs to function effectively and reduce the likelihood of encountering microbes that are resistant to the antibiotics patients are taking.Among those agents reported to have this activity are

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Section: Using Plants To Overcome Resistancementioning

confidence: 99%

Section: Using Plants To Overcome Resistancementioning

confidence: 99%

Plants for Addressing Multidrug Resistance: An Update

AbascalKathy

Yarnell

2013

Alternative and Complementary Therapies

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“…The species Artemisia annua L. (A. annua) presents an annual cycle and is a known natural producer of artemisinin, a sesquiterpene with antimalarial property (Yarnell & Abascal, 2004;Balunas & Kinghorn, 2005;Cavar et al, 2012;Herrmann et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Content and composition of the essential oil of Artemisia annua in two harvest times

Seixas

Castro

Barbosa

et al. 2019

J. Biotechnol. Biodivers.

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KeyworksArtemisia annua essential oil gas chromatography coupled to mass spectrometry medicinal plants Artemisia annua is traditionally used in the treatment for malaria due to presence of the active principle artemisinin. The aim of the present study was to evaluate the essential oil content and chemical composition of A. annua submitted to four doses of mineral fertilization in two harvest times. The seedlings of A. annua were cultivated in 10 L pots kept in a greenhouse. The tested doses of mineral fertilization were the following: without fertilization (D0), 50% of the recommended dose (D1), recommended dose (D2), and 150% of the recommended dose (D3). The samples for extracting the essential oils were collected at 60 and 125 days after transplantation (DAT). The essential oil was obtained by hydrodistillation using a Clevenger-type apparatus. Identification and relative percentage of the compounds of the essential oil were performed by gas chromatography coupled to mass spectrometry. The highest essential oil content obtained was 0.81% using the dose D0 at 60 DAT. The increase of the dose of mineral fertilization indicated a disadvantage with the reduction of the essential oil content in the two harvesting times. The major constituents found in the essential oil were camphor and borneol. The results indicate that A. annua could be an alternative source of borneol and camphor, active component with use in the chemical and pharmaceutical industry. R E S U M O Palavras-chavesArtemissia anuua óleo essencial cromatografia gasosa espectrometria de massa plantas medicinais Conteúdo e composição do óleo essencial da Artemisia annua em duas épocas de colheita. Artemisia annua é utilizada tradicionalmente para o tratamento da malária devido à presença do princípio ativo artemisinina. O objetivo do presente estudo foi avaliar o teor e a composição química do óleo essencial de A. annua submetida a quatro doses de adubação mineral em duas épocas de colheita. As mudas de A. annua foram cultivadas em vasos de 10 L mantidas em casa de vegetação. As doses testadas de fertilização mineral foram as seguintes: sem fertilização (D0), 50% da dose recomendada (D1), dose recomendada (D2) e 150% da dose recomendada (D3). As amostras para extração dos óleos essenciais foram coletadas aos 60 e 125 dias após o transplante (DAT). O óleo essencial foi obtido por hidrodestilação usando um aparelho do tipo Clevenger. A identificação e a porcentagem relativa dos compostos do óleo essencial foram realizadas por cromatografia gasosa acoplada à espectrometria de massa. O maior teor de óleo essencial obtido foi de 0,81% na dose D0 aos 60 DAT. O aumento da dose de adubação mineral indicou uma desvantagem com a redução do teor de óleo essencial nas duas épocas de colheita. Os constituintes majoritários encontrados no óleo essencial foram cânfora e borneol. Os resultados indicam que A. annua pode ser uma fonte alternative de borneol e cânfora, princípios ativos com uso na indústria química e farmacêutica. SEIXAS et al. / Journal of Biotechnology a...

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“…Homeopathic medicine china, produced from bark of Cinchona officinalis has been reported to cure low forms of fever (remittent or intermittent or malarial) and also kills parasites (Robin Murphy 2004;Shah 1999;Lessell 1993;Kent 1989). The Cinchona bark is the source of a variety of alkaloids which have been used as anti-fever agents and in treating malaria (Yarnell and Abascal 2004). China mother tincture (/) has been reported to reduce Plasmodium berghei infection in Balb/c mice and also enhanced the mean survival time of treated mice.…”

Section: Introductionmentioning

confidence: 99%

Effect of artesunate based combination therapy with homeopathic medicine china on liver and kidney of Plasmodium berghei infected mice

2012

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Present study has been undertaken to evaluate antimalarial potential and safety of artesunate based combination therapy with homeopathic medicine china (ϕ/30 potency) against Plasmodium berghei (NK-65), a lethal rodent malaria parasite. In combination therapy, the oral administration of artesunate (100 mg/kg) + china ϕ/30 proved to be highly efficacious as it completely cleared the blood stage infection. During the follow up period up to day 28, no recrudescence was observed and the survival rate was 100 %. Combination did not disturb the normal functioning of liver and kidney, as evident from the normal activity of ALP (190.5 ± 0.2 and 174.2 ± 9.12 IU/l), level of bilirubin (0.6 ± 0.33 and 0.73 ± 0.1 mg/dl), urea (28 ± 0.51 and 29.1 ± 0.03 mg/dl) and creatinine (0.9 ± 0.62 and 1.1 ± 0.1 mg/dl) in serum of treated mice on day 7 and 28 respectively. Present study points to better efficacy of china as an alternative drug partner in combination to enhance antimalarial efficacy of artesunate without affecting the liver and kidney functions of P. berghei infected BALB/c mice.

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Botanical Treatment and Prevention of Malaria: Part 2—Selected Botanicals

Abstract: T his article offers a review of studies on botanicals and their potential as treatments or adjunct treatments for malaria. The potential of using botanicals to overcome resistance to malarial drugs is also reviewed.

Cited by 14 publications

References 39 publications

Plants for Addressing Multidrug Resistance: An Update

Plants for Addressing Multidrug Resistance: An Update

Content and composition of the essential oil of Artemisia annua in two harvest times

Effect of artesunate based combination therapy with homeopathic medicine china on liver and kidney of Plasmodium berghei infected mice

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