Botanicals: An alternative remedy to radiotherapy-induced dysuria

Jaladat, Amir Mohammad; Atarzadeh, Fatemeh; Rezaeizadeh, Hossein; Mofid, Bahram; Mosalaie, Ahmad; Farhan, Farshid; Amin, Gholamreza

doi:10.1016/j.ctim.2014.11.004

Cited by 11 publications

(7 citation statements)

References 92 publications

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“…A prominent formulation, Gencydo ® containing aqueous Quince extracts and lemon juice is used for treatment of rhinitis and asthma in Europe. Quince leaf decoction has been traditionally used to cure nervousness, dysuria, insomnia, cough, cold abdominal cramps, diarrhea, fever, and hyperglycemia (Tabata et al, 1993 ; Tuzlaci and Tolon, 2000 ; Sezik et al, 2001 ; Jaladat et al, 2015 ). The seed mucilage has been used for healing dermal wounds (Ghafourian et al, 2015 ).…”

Section: Folk Medicinal Usesmentioning

confidence: 99%

Cydonia oblonga M., A Medicinal Plant Rich in Phytonutrients for Pharmaceuticals

et al. 2016

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Cydonia oblonga M. is a medicinal plant of family Rosaceae which is used to prevent or treat several ailments such as cancer, diabetes, hepatitis, ulcer, respiratory, and urinary infections, etc. Cydonia oblonga commonly known as Quince is rich in useful secondary metabolites such as phenolics, steroids, flavonoids, terpenoids, tannins, sugars, organic acids, and glycosides. A wide range of pharmacological activities like antioxidant, antibacterial, antifungal, anti-inflammatory, hepatoprotective, cardiovascular, antidepressant, antidiarrheal, hypolipidemic, diuretic, and hypoglycemic have been ascribed to various parts of C. oblonga. The polysaccharide mucilage, glucuronoxylan extruded from seeds of C. oblonga is used in dermal patches to heal wounds. This review focuses on detailed investigations of high-valued phytochemicals as well as pharmacological and phytomedicinal attributes of the plant.

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Section: Folk Medicinal Usesmentioning

confidence: 99%

Cydonia oblonga M., A Medicinal Plant Rich in Phytonutrients for Pharmaceuticals

et al. 2016

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“…On the other hand, mucilaginous herbal drugs have been introduced for the treatment of dysuria, which is secondary to the urethral-moisturizing layer defect [8].…”

Section: Discussionmentioning

confidence: 99%

Chronic Dysuria Following Ginger (Zingiber officinale) Use: A Case Report

Akbarzadeh

Heydari

Atarzadeh

et al. 2018

GMJ

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Background: Although ginger is considered a harmless remedial substance for a wide range of medical complaints, according to Persian medicinal texts, its long-term or high-dose consumption is potentially harmful. Case Report: The case of a 43-year-old man, with a complaint of urinary stream interruption, dysuria, and flank pain, following a non-prescribed use of ginger was reported. The symptoms were reported to persist for four years, despite some medical referrals. Remarkably, the symptoms were attested to be shrinking eight weeks after ginger-intake cessation; besides, no further intervention was asserted. Conclusion: The history of herbal remedies use should be considered in patients with any unexplained urinary symptoms. [GMJ.2018;7:e1086]

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“…Furthermore, evidence suggests that TCMs possess synergistic effects when combined with common chemotherapeutic drugs, enhancing toxicity against cancer cells and prolonging survival time (24,25). These combinations could also decrease the side effects of chemotherapeutic drugs and improve the quality of life in patients (26,27). …”

Section: Discussionmentioning

confidence: 99%

Synergistic effects of a novel lipid-soluble extract from Pinellia pedatisecta Schott and cisplatin on human cervical carcinoma cell lines through the regulation of DNA damage response signaling pathway

Zhang¹,

Zhang²,

Yu³

et al. 2017

Oncology Letters

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Herbal medicines have been recognized as an attractive approach for cancer therapy with minimal side effects. The present study investigated the type of interaction between a novel lipid-soluble extract from Pinellia pedatisecta Schott (PE) and cisplatin (CDDP) on human cervical cancer SiHa and CaSki cell lines in vitro. The mechanism of this combination was studied using cell proliferation, invasion and apoptosis assays, and by analyzing cell cycle distribution and protein expression, with a focus on DNA damage response (DDR) activation. Equipotent combinations of PE and CDDP were determined by isobologram analysis, in order to evaluate potential synergy. The combination index for SiHa cells was 0.43, and the index for CaSki cells was 0.68, indicating synergy. Treatment with PE and CDDP combined resulted in a significantly greater inhibition of invasion in the two cells, compared with either drug alone (SiHa, P<0.01; CaSki, P<0.001). This co-treatment induced significantly more apoptosis in the two cell lines, and arrested cells at the G0/G1 phase and G2/M phase in SiHa and CaSki, respectively, with a significant decrease (P<0.01) in S phase cells in the two cell lines. Combined PE and CDDP targeting synergistically enhanced the expression of markers of DDR (phosphorylation of ataxia-telangiectasia mutated, checkpoint kinase (Chk)-1, Chk-2, and γ-H2A histone family member X) in cells. These results suggest that PE and cisplatin act synergistically in cervical cancer cells with high DDR activation. The approach presented in the present study may have important implications for the pharmacological mechanism of Pinellia pedatisecta Schott and cervical cancer therapeutic strategies.

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Botanicals: An alternative remedy to radiotherapy-induced dysuria

Cited by 11 publications

References 92 publications

Cydonia oblonga M., A Medicinal Plant Rich in Phytonutrients for Pharmaceuticals

Cydonia oblonga M., A Medicinal Plant Rich in Phytonutrients for Pharmaceuticals

Chronic Dysuria Following Ginger (Zingiber officinale) Use: A Case Report

Synergistic effects of a novel lipid-soluble extract from Pinellia pedatisecta Schott and cisplatin on human cervical carcinoma cell lines through the regulation of DNA damage response signaling pathway

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