2012
DOI: 10.1016/j.imlet.2012.01.004
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Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice

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Cited by 39 publications
(29 citation statements)
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“…In addition, capping of receptors followed by their rapid removal from rituximab-opsonized lymphocytes is expected to not only reduce NK cell- and complement-mediated target cell death, but also limit the duration of trogocytosis (40). This is consistent with the observation that trogocytosis of rituximab-CD20 complexes on CD20-expressing EL4 cells does not lead to therapeutic effects in tumor-bearing mice (9) and can result in tumor escape during CD20-targeted therapy (43). Consequently, the dynamic behavior of the opsonized antigen on the target cell surface is expected to modulate tumor cell killing by trogocytosis.…”
Section: Discussionsupporting
confidence: 91%
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“…In addition, capping of receptors followed by their rapid removal from rituximab-opsonized lymphocytes is expected to not only reduce NK cell- and complement-mediated target cell death, but also limit the duration of trogocytosis (40). This is consistent with the observation that trogocytosis of rituximab-CD20 complexes on CD20-expressing EL4 cells does not lead to therapeutic effects in tumor-bearing mice (9) and can result in tumor escape during CD20-targeted therapy (43). Consequently, the dynamic behavior of the opsonized antigen on the target cell surface is expected to modulate tumor cell killing by trogocytosis.…”
Section: Discussionsupporting
confidence: 91%
“…A possibility that is not mutually exclusive is that the depletion of HER2 from the plasma membrane ablates growth factor-mediated signaling in HER2-addicted cells, resulting in cell death (6). Interestingly, in earlier studies trogocytosis has been shown to efficiently remove target receptors such as CD20 from the plasma membrane, leading to amelioration of the tumoricidal effects of NK cells and macrophages in the presence of antibodies such as rituximab (8, 9). Macrophages can have both tumor promoting or inhibitory effects (41, 42), and our observations extend this dichotomous behavior to trogocytosis.…”
Section: Discussionmentioning
confidence: 99%
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“…Although originally postulated to be mediated by FcγRI, shaving has since been demonstrated to be possible with any, and all, FcγR and seems simply to require productive contact between antigen-antibody complexes and FcγR expressing effector cells. Indeed in one mouse model system the inhibitory FcγRIIB was also demonstrated to mediate shaving [41]. It is noteworthy that these data regarding FcγR usage were obtained using an intraperitoneal tumour mouse model where previously complement had been demonstrated to play a role [42].…”
Section: Antigenic Modulation: Antibody Shavingmentioning
confidence: 85%
“…Antigen surface expression, which can serve as a diagnostic tool (D'Arena et al, 2000;Huh et al, 2001;Olejniczak et al, 2006;Hulkkonen et al, 2002;Tam et al, 2008;Ginaldi et al, 1998); and 3. Antigen modulation during therapy, which can be indicative for durable therapeutic efficacy (Beers et al, 2010;Hiraga et al, 2009;Beum et al, 2006Beum et al, , 2008Williams et al, 2006;Czuczman et al, 2008;Bil et al, 2010;Boross et al, 2012).…”
Section: Introductionmentioning
confidence: 99%