Both anxiety and joint laxity determine the olfactory features in panic disorder

Burón, Emma; Bulbena, Antonio; Bulbena-Cabré, Andrea; Rosado, Silvia; Pailhez, Guillem

doi:10.1016/j.psychres.2017.09.018

Cited by 12 publications

(16 citation statements)

References 56 publications

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“…A study comparing hypermobile and healthy patients 3 found structural, but more important, functional differences in key brain regions involved in emotional processing and arousal, which seem to mediate the link between hypermobility and anxiety 6 . More recently, our group found that patients with JHS and panic disorder exhibited higher olfactory acuity, increased odour reactivity and also greater odour awareness compared to healthy controls 20 . Our results in dogs seem to be in accordance with what has been found in human beings and present excitability as a potential trans diagnostic trait that could be involved in the relationship between joint hypermobility and anxiety.…”

Section: Introductionmentioning

confidence: 84%

First evidence for an association between joint hypermobility and excitability in a non-human species, the domestic dog

Bowen

Fatjó

Serpell

et al. 2019

Sci Rep

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There is a well-established relationship between joint hypermobility and anxiety in humans, that has not previously been investigated in other species. A population of 5575 assistance dogs were scored for both hip hypermobility and 13 behaviour characteristics using previously validated methods. Our results suggest a positive association between hip joint hypermobility and emotional arousal in domestic dogs, which parallel results found in people.

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Section: Introductionmentioning

confidence: 84%

First evidence for an association between joint hypermobility and excitability in a non-human species, the domestic dog

Bowen

Fatjó

Serpell

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…There is evidence of the increased olfactory sensitivity among anxiety disorders and even the association with joint hypermobility syndrome (JHS), which is a benign heritable collagen condition that is featured by increased laxity of the joints, resulting in enhanced distensibility in passive movements and hypermobility in active movements of joint ( 39 , 40 ). The previous study found that suffering from JHS in patients with panic disorder showed higher odor acuity, greater reactivity to smells and also increased odor awareness ( 16 ). A 15-year follow-up study indicated that JHS was a risk factor in the development of panic disorder, highlighting the importance of assessing JHS among patients with anxiety disorders ( 41 ).…”

Section: Discussionmentioning

confidence: 99%

“…Olfactory hallucinations have been significantly associated with self-reported anxiety symptoms and stressful life events ( 14 ). Several studies have specifically indicated an increased sensitivity to internal and external sensory cues in patients with panic disorder ( 15 , 16 ). The previous study also found that panic disorder patients appeared to be highly sensitive, reactive and aware of odors relative to healthy controls ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

First-episode olfactory hallucination in a patient with anxiety disorder: A case report

Jiang

Yuan

et al. 2022

Front. Psychiatry

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BackgroundOlfactory hallucination refers to olfactory perception in the absence of chemical stimuli. Although it has been associated with many neurological and psychotic disorders, it has rarely been reported as the first and only symptom in patients with anxiety disorder, and its treatment remains inadequate.Case summaryA 66-year-old woman who had been experiencing gradually worsening olfactory hallucinations for almost 4 years was diagnosed with generalized anxiety disorder. Olfactory hallucination disappeared after treatment with anti-anxiety drugs.ConclusionOlfactory hallucination can be the first and only symptom in patients with anxiety disorder and may be effectively treated with anti-anxiety medication. In fact, it can precede the diagnosis of anxiety disorder by several years.

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“…In this context, across psychiatric disorders the presence of hypermobility could represent a phenotypic subgroup of patients[ 103 ]. Hypermobility may also act as a clinical marker for specific target symptoms e.g ., anxiety[ 16 ], as demonstrated in hypermobile patients with schizophrenia[ 31 ] or for sensory hypersensitivities, e.g ., to olfactory stimuli in patients with panic disorder[ 104 ].…”

Section: Discussionmentioning

confidence: 99%

Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression

Sharp¹,

Critchley²,

Eccles³

2021

WJP

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The mind is embodied; thoughts and feelings interact with states of physiological arousal and physical integrity of the body. In this context, there is mounting evidence for an association between psychiatric presentations and the expression variant connective tissue, commonly recognised as joint hypermobility. Joint hypermobility is common, frequently under-recognised, significantly impacts quality of life, and can exist in isolation or as the hallmark of hypermobility spectrum disorders (encompassing joint hypermobility syndrome and hypermobile Ehlers-Danlos syndrome). In this narrative review, we appraise the current evidence linking psychiatric disorders across the lifespan, beginning with the relatively well-established connection with anxiety, to hypermobility. We next consider emerging associations with affective illnesses, eating disorders, alongside less well researched links with personality disorders, substance misuse and psychosis. We then review related findings relevant to neurodevelopmental disorders and stress-sensitive medical conditions. With growing understanding of mind-body interactions, we discuss potential aetiopathogenetic contributions of dysautonomia, aberrant interoceptive processing, immune dysregulation and proprioceptive impairments in the context of psychosocial stressors and genetic predisposition. We examine clinical implications of these evolving findings, calling for increased awareness amongst healthcare professionals of the transdiagnostic nature of hypermobility and related disorders. A role for early screening and detection of hypermobility in those presenting with mental health and somatic symptoms is further highlighted, with a view to facilitate preventative approaches alongside longer-term holistic management strategies. Finally, suggestions are offered for directions of future scientific exploration which may be key to further delineating fundamental mind-body-brain interactions.

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Both anxiety and joint laxity determine the olfactory features in panic disorder

Cited by 12 publications

References 56 publications

First evidence for an association between joint hypermobility and excitability in a non-human species, the domestic dog

First evidence for an association between joint hypermobility and excitability in a non-human species, the domestic dog

First-episode olfactory hallucination in a patient with anxiety disorder: A case report

Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression

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