Both compensation and recovery of skilled reaching following small photothrombotic stroke to motor cortex in the rat

Beyond the silence: Bilateral somatosensory stimulation enhances skilled movement quality and neural density in intact behaving rats

“…Neural density analysis (quantitative cytoarchitectonics) was performed using ImageJ 1.47b (http://imagej.nih.gov/ij) based on earlier descriptions [25]. A calibration was made by step tablet (http://rsb.info.nih.gov/ij/download.html) for optical density prior to the analysis of density.…”

“…Both left and right ROIs included the same cortical regions and nearly all six cortical layers. An absolute grey value index or the average grey value within the ROIs was separately measured for each region [25,26].…”

Thinning, movement, and volume loss of residual cortical tissue occurs after stroke in the adult rat as identified by histological and magnetic resonance imaging analysis

“…Neural density was inferred from measures of Grey value index (GVI) (Zilles et al, 1980;Moon et al, 2009). GVI was analyzed in tissue medial and lateral to the midpoint of the infarct (+1.7mm from bregma) from rats that were survived for 31 days post pial strip stroke.…”

Rat white matter injury model induced by endothelin-1 injection: technical modification and pathological evaluation

“…To overcome this difficulty, we could have conducted other tests that could have been minimally affected by compensation or repeated testing, such as the tapered/ ledged beam walking test and Montoya's staircase test, a task for our future research. In any case, this phenomenon of spontaneous recovery of locomotor function is frequently observed after lacunar infarction in patients as well as in stroke animal models (Tanaka et al 2008, Moon et al 2009). Moreover, the forced swimming test revealed that this model did not show apparent sign of depressive mood at 1 month after the operation.…”