Both here and there: Simultaneous expression of autonomous spatial memories in rats

Fenton, André A.; Wesierska, M; Kaminsky, Yu.; Bureš, Jan

doi:10.1073/pnas.95.19.11493

Cited by 103 publications

(71 citation statements)

References 18 publications

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“…Previous functional inactivation of the dorsal hippocampus blocked both the acquisition of spatial memories and the retrieval of long‐term spatial avoidance memories on the APA (Fenton et al. 1998; Cimadevilla et al. 2000; Kubik and Fenton 2005; Wesierska et al.…”

Section: Discussionmentioning

confidence: 99%

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Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

et al. 2016

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BackgroundSingle‐episode anesthetic exposure is the most prevalent surgery‐related incidence among young children in the United States. Although numerous studies have used animals to model the effects of neonatal anesthetics on behavioral changes later on in life, our understanding of the functional consequences to the developing brain in a comprehensive and clinically relevant manner is unclear.MethodsThe volatile anesthetic, sevoflurane (sevo) was administered to C57BL6 postnatal day 7 (P7) mice in a 40% oxygen and 60% nitrogen gas mixture. In order to examine the effects of sevo alone on the developing brain in a clinically relevant manner, mice were exposed to an average of 2.38 ± 0.11% sevo for 2 h. No sevo (control) mice were treated in an identical manner without sevo exposure. Mice were examined for cognition and neuropsychiatric‐like behavioral changes at 1–5 months of age.ResultsUsing the active place avoidance (APA) test and the novel object recognition (NOR) test, we demonstrated that P7 sevo‐treated mice showed a deficit in learning and memory both during periadolescence and adulthood. We then employed a battery of neuropsychiatric‐like behavioral tests to examine social interaction, communication, and repetitive behavior. Interestingly, compared to the no‐sevo–treated group, sevo‐treated mice showed significant reductions in the time interacting with a novel mouse (push–crawl and following), time and interaction in a chamber with a novel mouse, and time sniffing a novel social odor.ConclusionsOur study established that single‐episode, 2‐h sevo treatment during early life impairs cognition later on in life. With this approach, we also observed neuropsychiatric‐like behavior changes such as social interaction deficits in the sevo‐treated mice. This study elucidated the effects of a clinically relevant single‐episode sevo application, given during the neonatal period, on neurodevelopmental behavioral changes later on in life.

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Section: Discussionmentioning

confidence: 99%

“…The mouse was trained to avoid a 60° shock zone, which could be defined within a region of the room identified by multiple visual cues (Fenton et al. 1998; Wesierska et al. 2005).…”

Section: Methodsmentioning

confidence: 99%

Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

et al. 2016

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“…The place avoidance system (Bio-Signal Group) was adapted from that used in previous studies (Bureš et al, 1997;Fenton et al, 1998;Cimadevilla et al, 2000Cimadevilla et al, , 2001. The arena was a uniform metal disk, 82 cm in diameter, with a 5-cm-high wall.…”

Section: Room؉ Place Avoidance Apparatusmentioning

confidence: 99%

“…1C). Note, however, that there is an additional challenge in RoomϩArenaϪ avoidance and even more so in the RoomϩArenaϩ (Fenton et al, 1998) avoidance task in which the rat must avoid both a stationary and a rotating place, because entering either region is punished by footshock. The rat must segregate stationary room and rotating arena stimuli and selectively associate shock with the appropriate stimulus subset.…”

Section: Segregation and Representation-distinct Hippocampal Functionsmentioning

confidence: 99%

Behavioral Evidence That Segregation and Representation Are Dissociable Hippocampal Functions

Kubík¹,

Fenton²

2005

J. Neurosci.

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Hippocampal activity is thought to encode spatial representations in a distributed associative network. This idea predicts that partial hippocampal lesions would spare acquisition and impair retrieval of a place response as long as enough connections remained intact to encode associations. Water maze experiments supported the predictions, but the prediction of impaired retrieval was not supported when tetrodotoxin (TTX) was injected into one hippocampus and rats were tested in a place avoidance task on a rotating arena with shallow water. The rotation dissociated relevant distal stimuli from irrelevant self-motion stimuli. To explain the discrepancy, we hypothesized that the segregation of relevant and irrelevant stimuli and stimuli association into representations are distinct hippocampus-dependent operations, and whereas associative representation is more sensitive to disruption during retrieval than learning, stimulus segregation is more sensitive to disruption during learning than during retrieval. The following predictions were tested: (1) the TTX injection would spare learning but (2) impair retrieval of a place response in the water maze, which has a high associative representational demand but a low demand for segregation; (3) the injection would impair learning but (4) spare retrieval of place avoidance in the rotating arena filled with water, which has a high demand for stimulus segregation but a low associative representational demand. All four predictions were confirmed. The hypothesis also explains the pattern of sparing and impairment after the TTX injection in other place avoidance task variants, leading us to conclude that stimulus separation and association representation are dissociable functions of the hippocampus.

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“…Recent research (17,18,21) demonstrated that rats learn to efficiently avoid an unmarked place on a dark rotating arena. Navigation in the arena frame could be supported by substratal idiothesis and by substratal cues, but not by extramaze cues and inertial idiothesis.…”

Section: Methodsmentioning

confidence: 99%

Substratal idiothetic navigation of rats is impaired by removal or devaluation of extramaze and intramaze cues

Stuchlı́k

Fenton²,

Bureš³

2001

Proc. Natl. Acad. Sci. U.S.A.

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The spatial orientation of vertebrates is implemented by two complementary mechanisms: allothesis, processing the information about spatial relationships between the animal and perceptible landmarks, and idiothesis, processing the substratal and inertial information produced by the animal's active or passive movement through the environment. Both systems allow the animal to compute its position with respect to perceptible landmarks and to the already traversed portion of the path. In the present study, we examined the properties of substratal idiothesis deprived of relevant exteroceptive information. Rats searching for food pellets in an arena formed by a movable inner disk and a peripheral immobile belt were trained in darkness to avoid a 60°sector; rats that entered this sector received a mild foot shock. The punished sector was defined in the substratal idiothetic frame, and the rats had to determine the location of the shock sector with the use of substratal idiothesis only, because all putative intramaze cues were made irrelevant by angular displacements of the disk relative to the belt. Striking impairment of place avoidance by this ''shuffling procedure'' indicates that effective substratal idiothesis must be updated by exteroceptive intramaze cues.

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Both here and there: Simultaneous expression of autonomous spatial memories in rats

Cited by 103 publications

References 18 publications

Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

Behavioral Evidence That Segregation and Representation Are Dissociable Hippocampal Functions

Substratal idiothetic navigation of rats is impaired by removal or devaluation of extramaze and intramaze cues

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