Both IgG and IgM anti-beta2 glycoprotein I antibodies assays are clinically useful to the antiphospholipid syndrome diagnosis

Abstract

Both IgG and IgM anti-beta2GPI assays were useful when clinical features of APS presented, even its standardization is ongoing. A decreased by half sensitivity of LA in PM compared with that in VT underlines the importance of adding anti-beta2GPI in PM of APS, especially IgM isotype although recent review questioned its significance.

Evaluation of three fully automated immunoassay systems for detection of IgA anti‐beta 2‐glycoprotein I antibodies

“…Therefore, the poor performance cannot be attributed to low incorporation of the antigen carrier (B2GPI) because if this were not true, the detection system of IgG antibodies class would also have low efficiency. The determination of other autoantibodies of IgG isotype also showed excellent performance, our observations being in agreement with other previously published .…”

16th International Congress on Antiphospholipid Antibodies Task Force Report on Obstetric Antiphospholipid Syndrome

“…Finally, women negative for LA and with a single positive aCL or aβ2GPI antibody result have a low risk of adverse pregnancy outcome, as do those with low antibody titers and IgM isotype results. 20,25–30…”

What’s new in obstetric antiphospholipid syndrome

“…Finally, women negative for LA and with a single positive aCL or ab2-GP-I antibody result leading to their diagnosis of APS have a low risk of adverse pregnancy outcome as do those with low antibody titers and IgM isotype results. 17,[27][28][29][30][31][32]…”