Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in mice

Zhou, Ming; Bakker, Eveline H.M.; Velzing, Els H.; Berger, Stefan; Oitzl, Melly S.; Joëls, Marian; Krugers, Harm J.

doi:10.1016/j.nlm.2010.09.005

Cited by 74 publications

(76 citation statements)

References 43 publications

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“…Still, our data suggest a relationship between these receptors in our experiments [without stress (Manuel et al, 2014) and with stress (reported here)]. Thus, this relationship may also be the result of an interaction of the UCS with the task, as both MR and GR are involved in learning and memory (Cerqueira et al, 2005;ter Horst et al, 2012;Lupien and McEwen, 1997;Zhou et al, 2010). The relative balance between these receptors affects memory in adults and changes in the mr/grα ratio have been associated with decreased learning and memory (de Kloet et al, 1999;Lupien and Lepage, 2001).…”

Section: Research Articlesupporting

confidence: 50%

Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen Long-Fin zebrafish (Danio rerio Hamilton): stronger effects in the resting phase than in the active phase

Manuel

Gorissen

Zethof

et al. 2014

Journal of Experimental Biology

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Zebrafish (Danio rerio Hamilton) are increasingly used as a model to study the effects of chronic stress on brain and behaviour. In rodents, unpredictable chronic stress (UCS) has a stronger effect on physiology and behaviour during the active phase than during the resting phase. Here, we applied UCS during the daytime (active phase) for 7 and 14 days or during the night-time (resting phase) for 7 nights in an in-house-reared Tuebingen long-fin (TLF) zebrafish strain. Following UCS, inhibitory avoidance learning was assessed using a 3 day protocol where fish learn to avoid swimming from a white to a black compartment where they will receive a 3 V shock. Latencies of entering the black compartment were recorded before training (day 1; first shock) and after training on day 2 (second shock) and day 3 (no shock, tissue sampling). Fish whole-body cortisol content and expression levels of genes related to stress, fear and anxiety in the telencephalon were quantified. Following 14 days of UCS during the day, inhibitory avoidance learning decreased (lower latencies on days 2 and 3); minor effects were found following 7 days of UCS. Following 7 nights of UCS, inhibitory avoidance learning decreased (lower latency on day 3). Whole-body cortisol levels showed a steady increase compared with controls (100%) from 7 days of UCS (139%), to 14 days of UCS (174%) to 7 nights of UCS (231%), suggestive of an increasing stress load. Only in the 7 nights of UCS group did expression levels of corticoid receptor genes (mr, grα, grβ) and of bdnf increase. These changes are discussed as adaptive mechanisms to maintain neuronal integrity and prevent overload, and as being indicative of a state of high stress load. Overall, our data suggest that stressors during the resting phase have a stronger impact than during the active phase. Our data warrant further studies on the effect of UCS on stress axis-related genes, especially grβ; in mammals this receptor has been implicated in glucocorticoid resistance and depression.

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Section: Research Articlesupporting

confidence: 50%

Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen Long-Fin zebrafish (Danio rerio Hamilton): stronger effects in the resting phase than in the active phase

Manuel

Gorissen

Zethof

et al. 2014

Journal of Experimental Biology

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“…4a and b). While the doses of RU38486 and spironolactone used in these studies have been effective in previous behavioral and electrophysiological experiments Kumar et al, 2007;Macdougall & Howland, 2012;Mackowiak et al, 2008;Pugh et al, 1997;Zhou et al, 2010), we cannot rule out the possibility that higher doses of the drugs would have blocked the facilitation of reversal learning by acute stress (Adamec, Muir, Grimes, & Pearcey, 2007;Koenig & Olive, 2004). Inspection of the data revealed that drug treatment did subtly alter behavior in the absence of stress.…”

Section: Discussionmentioning

confidence: 81%

“…; Sigma), or spironolactone (50 mg/kg; s.c.; Tocris Biochemicals). These doses were chosen on the basis of previous studies that had shown that they are sufficient to block GR-mediated Macdougall & Howland, 2012;Pugh, Fleshner, & Rudy, 1997;Zhou et al, 2010) and MR-mediated (Kumar et al, 2007;Mackowiak et al, 2008;Zhou et al, 2010) effects in rodents. Average response latencies of the rats were not affected by either stress or drug treatment in any of the experiments (data not shown).…”

Section: Stress and Drug Treatmentmentioning

confidence: 99%

Effects of acute restraint stress on set-shifting and reversal learning in male rats

Thai

Zhang

Howland

2012

Cogn Affect Behav Neurosci

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Exposure to acute stress alters cognition; however, few studies have examined the effects of acute stress on executive functions such as behavioral flexibility. The goal of the present experiments was to determine the effects of acute periods of stress on two distinct forms of behavioral flexibility: set-shifting and reversal learning. Male Sprague-Dawley rats were trained and tested in an operant-chamber-based task. Some of the rats were exposed to acute restraint stress (30 min) immediately before either the set-shifting test day or the reversal learning test day. Acute stress had no effect on setshifting, but it significantly facilitated reversal learning, as assessed by both trials to criterion and total errors. In a second experiment, the roles of glucocorticoid (GR) and mineralocorticoid receptors (MR) in the acute-stress-induced facilitation of reversal learning were examined. Systemic administration of the GR-selective antagonist RU38486 (10 mg/kg) or the MRselective antagonist spironolactone (50 mg/kg) 30 min prior to acute stress failed to block the facilitation on reversal learning. The present results demonstrate a dissociable effect of acute stress on set-shifting and reversal learning and suggest that the facilitation of reversal learning by acute stress may be mediated by factors other than corticosterone.

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“…Various studies have shown that activation of GRs enhance hippocampus-dependent memory formation (Oitzl et al 2001;Roozendaal et al 2009;Zhou et al 2010). Enhanced memory formation may involve BDNF-TrkB-MAPK-synapsin Ia/Ib signaling (Revest et al 2005(Revest et al , 2010(Revest et al , 2014 and CaMKII-BDNF-CREB signaling (Chen et al 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Then, the animals were transferred back into their home cage. Freezing behavior, defined as no body movements except those related to respiration, was determined every 2 sec throughout training (Zhou et al 2010). Twenty-four hours later, one animal at a time was placed in context A for 3 min without receiving footshock and freezing behavior was scored.…”

Section: Fear Conditioningmentioning

confidence: 99%

mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory

et al. 2015

Self Cite

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Glucocorticoid hormones, via activation of their receptors, promote memory consolidation, but the exact underlying mechanisms remain elusive. We examined how corticosterone regulates AMPA receptors (AMPARs), which are crucial for synaptic plasticity and memory formation. Combining a live imaging fluorescent recovery after photobleaching approach with the use of the pH-sensitive GFP-AMPAR tagging revealed that corticosterone enhances the AMPAR mobile fraction and increases synaptic trapping of AMPARs in hippocampal cells. In parallel, corticosterone-enhanced AMPARmediated synaptic transmission. Blocking the mammalian target of rapamycin (mTOR) pathway prevented the effects of corticosterone on both AMPAR trapping-but not on the mobile fraction-and synaptic transmission. Blocking the mTOR pathway also prevented the memory enhancing effects of corticosterone in a contextual fear-conditioning paradigm. We conclude that activation of the mTOR pathway is essential for the effects of corticosterone on synaptic trapping of AMPARs and, possibly as a consequence, fearful memory formation.

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Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in mice

Cited by 74 publications

References 43 publications

Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen Long-Fin zebrafish (Danio rerio Hamilton): stronger effects in the resting phase than in the active phase

Unpredictable chronic stress decreases inhibitory avoidance learning in Tuebingen Long-Fin zebrafish (Danio rerio Hamilton): stronger effects in the resting phase than in the active phase

Effects of acute restraint stress on set-shifting and reversal learning in male rats

mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory

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