Both Percent Diameter Stenosis (%DS) and Coronary Flow Reserve (CFR) can be Derived Directly from Myocardial Perfusion Imaging (MPI) using FMTVDM©℗ and Measurement of Isotope Redistribution

Fleming, Richard M; Fleming, Matthew R; Chaudhuri, Tapan K.; McKusick, Andrew; Dooley, William C.; Glover, Charles

doi:10.4172/2155-9619.1000353

Cited by 9 publications

(10 citation statements)

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“…By contrast, more specific markers of inflammatory coronary artery disease (homocysteine, CRP, IL-6) and myocardial blood flow itself demonstrated a worsening of disease independent of changes in weight, BMI or lipid levels. Recently published studies [53,54] continue to confirm our prior contention that inflammation is the underlying cause of heart disease. The changes in CRP seen in these studies reflect changes in individuals with coronary artery disease, thereby making the specificity of CRP greater than it would be in the general population.…”

Section: Archives Of Medicinementioning

confidence: 52%

“…In this study changes in IL-6 tightly overlapped changes seen in coronary blood flow as determined by nuclear imaging of the heart, especially "quantitative" myocardial perfusion imaging [54][55][56]. This study indicates the need for concern and emphasizes the limitations of prior studies which have looked only at weight and lipid responses or have not addressed caloric, saturated fat and/or refined processed carbohydrate reduction.…”

Section: Archives Of Medicinementioning

confidence: 60%

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Weight Loss vs. Heart Disease: Weight Loss is Determined by Caloric Intake. Heart Disease is Determined by Dietary Inflammatory Components. True Quantification of Coronary Artery Disease Measured by AI Using FMTVDM©℗

Rm¹,

Mr²,

Gm³

et al. 2018

Arch Med

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Background: Obesity is caused by eating behaviours. Adherence to all diets has been extremely poor, thus, comparative data on health effects of different diets over periods of a year or more are limited.Objective: To treat the root causes of obesity by modifying the eating behaviours and to compare the long-term (one year) cardiovascular health affects using three major types of diets under isocaloric conditions including the impact on surrogate markers and most importantly the quantitative measurement of actual coronary artery disease as quantitatively defined using FMTVDM ©℗ . Methods: Controlled experiment with one year of dieting and a four-month postdiet follow-up in a private practice setting.Participants: 120 obese, otherwise healthy, adults who are not being seen for other health conditions.Interventions: Participant agreement to follow and self-manage diet, physician supportive nondirective diet counseling providing follow-up at six-week intervals on food selection and portion control to achieve 1500-1600 calorie intake of assigned diet type: low-to moderate-fat, lowered-carbohydrate, or vegan.Outcomes: Adherence, weight loss, changes in 14 cardiovascular lipids and coronary blood flow health risk indices.Results: One-year body mass changes did not differ by diet (P>0.999). Effect sizes (R, R2) for differences between diets were statistically significant for all indices. Coronary blood flow, R (CI95%)=0.48 to 0.69, improved with low-to-moderate-fat and declined with lowered carbohydrate diets. Inflammatory factor Interleukin-6 (R=0.51 to 0.71) increased with lowered carbohydrate and decreased with low-tomoderate-fat diets.Conclusions: Appropriate diet and exercise with time intensive diet counseling can be effective in weight reduction and maintenance for most people. Nondirective supportive counseling leads to high diet program participant retention. One year of a lowered-carbohydrate diet significantly increases cardiovascular risks. Longterm adherence to a low-to-moderate-fat diet significantly reduces cardiovascular risk factors. Vegan diets are intermediate but close to low-to-moderate-fat in effects. Lowered-carbohydrate dieters were least inclined to continue dieting after conclusion of the study. Reductions in coronary blood flow can be reversed with appropriate dietary intervention. The major dietary effect on atherosclerotic coronary artery disease is inflammation and not weight loss.

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Section: Archives Of Medicinementioning

confidence: 52%

Section: Archives Of Medicinementioning

confidence: 60%

Weight Loss vs. Heart Disease: Weight Loss is Determined by Caloric Intake. Heart Disease is Determined by Dietary Inflammatory Components. True Quantification of Coronary Artery Disease Measured by AI Using FMTVDM©℗

Rm¹,

Mr²,

Gm³

et al. 2018

Arch Med

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“…This study also emphasizes the importance of answering the question at hand; viz. if we are looking for inflammatory coronary artery disease, we must look for it with a truly quantitative test, which measures [24,25,35] coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

“…As previously [15,20] described these regions of reduced blood flow can be quantified to determine both the extent and reduction in coronary blood flow throughout the heart, compared to normal blood flow. This cumulative reduction in maximal coronary blood flow is the ischemic index (II) and can be used to detect minor changes in coronary blood flow that can otherwise go clinically undetected unless a "vulnerable inflammatory plaque" ruptures [24,25]. Here, the long-term effect of a LMF diet shows significant improvement in coronary blood flow and in regression of inflammatory coronary artery disease (Figures 2A and 2B).…”

mentioning

confidence: 99%

Long-Term Health Effects of the Three Major Diets Under Self-Management with Advice, Yields High Adherence and Equal Weight Loss, but very different Long-Term Cardiovascular Health Effects as Measured by Myocardial Perfusion Imaging and Specific Markers of Inflammatory Coronary Artery Disease

Fleming¹,

Fleming²,

Harrington³

et al. 2018

BJSTR

Self Cite

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Background: Obesity is caused by eating behaviours. Adherence to all diets has been extremely poor, thus, comparative data on health effects of different diets over periods of a year or more are limited. This study was designed to treat the root causes of obesity by modifying the eating behaviours and to compare the long-term (one year) cardiovascular health affects using three major diets under isocaloric conditions. Methods: 120 obese, otherwise healthy, adults were recruited including 63 men and 57 women with a mean age and BMI of 43.7 years and 42.4 respectively. Participants agreed to follow and self-manage diet with follow-up at six-week intervals to achieve 1500-1600 calorie intake of assigned diet type: low-to moderate-fat, lowered-carbohydrate, or vegan. Adherence, weight loss, changes in 14 cardiovascular lipids and coronary blood flow health risk indices were measured.Results: One-year body mass changes did not differ by diet (P>.999). Effect sizes (R, R2) were statistically significant for all indices. Coronary blood flow, R (CI95%) = .48 to .69, improved with low-to-moderate-fat and declined with lowered carbohydrate diets. Inflammatory factor Interleukin-6 (R = .51 to .71) increased with lowered carbohydrate and decreased with low-to-moderate-fat diets. Conclusion:One-year lowered-carbohydrate diet significantly increases cardiovascular risks, while a low-to-moderate-fat diet significantly reduces cardiovascular risk factors. Vegan diets were intermediate. Lowered-carbohydrate dieters were least inclined to continue dieting after conclusion of the study. Reductions in coronary blood flow reversed with appropriate dietary intervention. The major dietary effect on atherosclerotic coronary artery disease is inflammation and not weight loss.

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“…As recently presented [5] and as published [6][7][8][9][10], for our scintillation tools to be accurate, consistent, and reproducible around the world, we must be able to calibrate these tools (nuclear cameras) to a known standard. Standards are constant and unchanging.…”

mentioning

confidence: 99%

Nuclear Imaging: Physician Confusion Over True Quantification and Isotope Redistribution

Richard¹,

FHHI-OmnificImaging-Camelot²,

Matthew³

et al. 2020

J Clin Cases Rep

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Clinicians are beginning to understand the importance of quantification for use in medicine, particularly nuclear medicine. With the recent introduction of mandates by CMS, ASNC, and the SNMMI for quantification, it is not surprising that professional papers are beginning to be published on the topic. One recent publication paper by Zhao et al. demonstrates the misunderstanding that is plaguing the field of modern nuclear medicine. The second publication by Dorbala et al. discusses a major flaw in the current understanding of redistribution measurements of isotopes such as Sestamibi and Tetrofsomin

show abstract

Both Percent Diameter Stenosis (%DS) and Coronary Flow Reserve (CFR) can be Derived Directly from Myocardial Perfusion Imaging (MPI) using FMTVDM©℗ and Measurement of Isotope Redistribution

Cited by 9 publications

References 0 publications

Weight Loss vs. Heart Disease: Weight Loss is Determined by Caloric Intake. Heart Disease is Determined by Dietary Inflammatory Components. True Quantification of Coronary Artery Disease Measured by AI Using FMTVDM©℗

Weight Loss vs. Heart Disease: Weight Loss is Determined by Caloric Intake. Heart Disease is Determined by Dietary Inflammatory Components. True Quantification of Coronary Artery Disease Measured by AI Using FMTVDM©℗

Long-Term Health Effects of the Three Major Diets Under Self-Management with Advice, Yields High Adherence and Equal Weight Loss, but very different Long-Term Cardiovascular Health Effects as Measured by Myocardial Perfusion Imaging and Specific Markers of Inflammatory Coronary Artery Disease

Nuclear Imaging: Physician Confusion Over True Quantification and Isotope Redistribution

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