Both the Complexity of Tight Junctions and Endothelial Transcytosis Are Increased During BBB Postnatal Development in Rats

Li, Wei; Zou, Jinlong; Shang, Junkui; Gao, Chenhao; Sun, Ruihua; Liu, Ruijie; Cao, Huixia; Wang, Yanliang; Zhang, Jiewen

doi:10.3389/fnins.2022.850857

Cited by 5 publications

(1 citation statement)

References 50 publications

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“… 51 , 212 , 213 However, these postnatal periods also see expansion and refinement of the brain vascular architecture, with changes in endothelial transport and astrocyte expression. 30 , 214 These features of BBB development suggest that neurovascular function may be sensitive to positive and negative environmental interventions; thus, access to an enriched environment early in life could potentially exert lasting changes in brain and behaviour. Indeed, structural complexity during postnatal development is associated with increased vascular branching and expression of the angiogenic VEGF and glucose transporters, at least in the rodent visual cortex.…”

Section: Barrier–environment Interactions In Development and Agingmentioning

confidence: 99%

Barrier–environment interactions along the gut–brain axis and their influence on cognition and behaviour throughout the lifespan

Paton

Solano

Coulombe-Rozon

et al. 2023

jpn

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Environment is known to substantially alter mental state and behaviour across the lifespan. Biological barriers such as the blood–brain barrier (BBB) and gut barrier (GB) are major hubs for communication of environmental information. Alterations in the structural, social and motor environment at different stages of life can influence function of the BBB and GB and their integrity to exert behavioural consequences. Importantly, each of these environmental components is associated with a distinct immune profile, glucocorticoid response and gut microbiome composition, creating unique effects on the BBB and GB. These barrier–environment interactions are sensitive to change throughout life, and positive or negative alterations at critical stages of development can exert long-lasting cognitive and behavioural consequences. Furthermore, because loss of barrier integrity is implicated in pathogenesis of mental disorders, the pathways of environmental influence represent important areas for understanding these diseases. Positive environments can be protective against stress- and age-related damage, raising the possibility of novel pharmacological targets. This review summarizes known mechanisms of environmental influence — such as social interactions, structural complexity and physical exercise — on barrier composition, morphology and development, and considers the outcomes and implications of these interactions in the context of psychiatric disorders.

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Section: Barrier–environment Interactions In Development and Agingmentioning

confidence: 99%

Barrier–environment interactions along the gut–brain axis and their influence on cognition and behaviour throughout the lifespan

Paton

Solano

Coulombe-Rozon

et al. 2023

jpn

View full text Add to dashboard Cite

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Electroacupuncture Ameliorates Neuronal Injury by NLRP3/ASC/Caspase-1 Mediated Pyroptosis in Cerebral Ischemia-Reperfusion

Tang,

Li,

et al. 2023

Mol Neurobiol

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NLRP3/ASC/Caspase-1 mediated pyroptosis is one of the important causes of cerebral ischemiareperfusion (I/R) injury. Electroacupuncture (EA) is widely used in clinical treatment of ischemic stroke. However, mechanism of EA on ischemic stroke remains unclear. Therefore, on basis of previous work, this study used middle cerebral artery occlusion (MCAO) 2h and then reperfusion 7d in rats to simulate brain I/R process. EA with Bahui (GV20) and Zusanli (ST36) and VX-765 (a speci c inhibitor of Caspase-1) were performed. In this study, we found that EA improved cerebral infarct size and neuronal damage, including ultrastructural injury, and ameliorated nitro/oxidative stress in cerebral I/R. Additionally, EA treatment signi cantly decreased ASC, Caspase-1, GSDMD and IL-1β expression and VX-765 treatment signi cantly decreased NLRP3, Caspase-1 and IL-1β expression. This proved that EA can regulate NLRP3/ASC/Caspase-1 mediated pyroptosis, improve neuronal injury during cerebral I/R and provide basic experimental data for clinical treatment.

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Mitochondrial ferritin upregulation reduced oxidative stress and blood-brain-barrier disruption by maintaining cellular iron homeostasis in a neonatal rat model of germinal matrix hemorrhage

Yuan,

He,

Yang

et al. 2024

Experimental Neurology

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Both the Complexity of Tight Junctions and Endothelial Transcytosis Are Increased During BBB Postnatal Development in Rats

Cited by 5 publications

References 50 publications

Barrier–environment interactions along the gut–brain axis and their influence on cognition and behaviour throughout the lifespan

Barrier–environment interactions along the gut–brain axis and their influence on cognition and behaviour throughout the lifespan

Electroacupuncture Ameliorates Neuronal Injury by NLRP3/ASC/Caspase-1 Mediated Pyroptosis in Cerebral Ischemia-Reperfusion

Mitochondrial ferritin upregulation reduced oxidative stress and blood-brain-barrier disruption by maintaining cellular iron homeostasis in a neonatal rat model of germinal matrix hemorrhage

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