Botox® to reduce drooling in a paediatric population with neurological impairments: a Phase I study

Abstract

In the clinical setting of the Drooling Treatment Project, the results indicated that the context in which drooling occurs is an important factor and suggested the value of considering the situational context when making drooling judgments. Further, there was a difference in the pattern of response between the children with cerebral palsy and those with operculum syndrome, suggesting that aetiology may be involved in the response to Botox®.

Effect of recurrent onabotulinum toxin a injection into the salivary glands: An ultrasound measurement

“…It is considered to have efficacy rates ranging from 89% to 95% when injected in both submandibular and parotid glands. BoNTs injections improve symptoms effectively but temporarily; patients usually require more than one injection for drooling control . The effect by injection varies from 6 weeks to 6 months.…”

“…BoNTs injections improve symptoms effectively but temporarily; patients usually require more than one injection for drooling control. 12,13 The effect by injection varies from 6 weeks to 6 months.…”

Drooling quantification: Correlation of different techniques

“…Furthermore, objective scales are time-consuming and impractical in the clinical settings (Alrefai, Aburahma, & Khader, 2009;Gok et al, 2013;Hay & Penn, 2011).…”

“…They also found that objective methods such as using dental rolls are difficult to carry out in children for fear of choking. In another study by Hay (2011), subjective rating scales were shown as non-aggressive qualitative tools for drooling measurement; they indicate drooling reduction in daily situations versus quantitative objective tools which only represent decrease of salivary flow that does not necessarily shows change of drooling severity.…”

Treatment of drooling with scopolamine in pediatric ICU: A case series report

“…The rate of improvement in drooling is directly proportional to the quantity of toxin administered. The effects of a higher dosage of botulinum toxin are unknown, and the effect of this drug is transitory, ranging from 6 weeks to 12 months …”