Botulinum toxin originated from the Latin term ‘botulus’ meaning ‘sausage’. Botulinum toxin is a bacterial extract which acts at the synaptic level and inhibits the neuronal uptake of acetylcholine causing inhibition of muscular contraction. This property of botox proves to be useful in various muscle spastic disorders. Commercially accessible under the brand label of Botox and is universally used in cosmetic field in managing wrinkles and crow lines correspondingly it has multitude of use in treating innumerable maxillofacial complex disorders like Temperomandibular disorders, Hypertonicity of lips, gummy smiles, Bruxism, trigeminal neuralgia and other types of facial pain. Botox is regarded as minimally invasive procedure with promising results in muscular disorders as well as cosmetic purpose. Botulinum when used in therapeutic doses proves to be boon to mankind. The effects are dose dependent as it comes with the black box warning. Overcoming this disadvantage of botox, the newly emerged Frotox ® based on the (Focussed Cold Therapy) is used nowadays and proves to be more efficacious.This article describes in detail about the origin of the toxin, it’s commercially available forms. It also describes the clinical technique, its pros and cons with instructions with patient as well as operator point of view.