Botryoid Wilms tumor: a non-existent “entity” causing diagnostic and staging difficulties

Vujanić, Gordan; Lena, Marco Schiavo; Sebire, Neil J.

doi:10.1007/s00428-018-2500-4

Cited by 14 publications

(14 citation statements)

References 35 publications

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“…The predisposing syndromes associated with BGP were scarcely described. Among 77 patients (8 BWT), Vujanić et al 2 reported only 1 patient with Denys-Drash syndrome. In our cases, 2 children had a WT1 mutation, in relation with the bilateral disease.…”

Section: Discussionmentioning

confidence: 99%

“…In literature, nephrogenic rests were found in 50% of tumors with BGP. 2 Yanai et al 6 suggested that the BGP originated from the ILNR of the pelvis. The extension of BGP as an ILNR from a genuine WT could be explained by the known location of ILNR inside the renal lobules that thus could expand in the collecting system and the renal pelvis by itself with no concomitant WT extension, on the contrary of perilobar nephrogenic rests that are always located adjacent to the peripheral margin of the renal lobule, and directly expand in the cortex.…”

Section: Discussionmentioning

confidence: 99%

“…The histologic type of WT was stromal or mixed type in our patients and in both kidneys for each patient, but the BGP itself was an ILNR every time. In literature, nephrogenic rests were found in 50% of tumors with BGP 2. Yanai et al6 suggested that the BGP originated from the ILNR of the pelvis.…”

Section: Discussionmentioning

confidence: 99%

“…BGP itself did not change the stage or the prognosis of the disease. Vujanić et al2 concluded that the intrapelvic botryoid growth should not be a reason for upstaging a tumor. Even when tumor extends into the ureter and reaches the bladder without infiltrating the wall, it should still be regarded as stage 1 if completely excised.…”

Section: Discussionmentioning

confidence: 99%

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Nephron Sparing Surgery in Bilateral Wilms Tumors With Botryoid Growth Pattern

Mrad¹,

Audry²,

Tabone

et al. 2021

Journal of Pediatric Hematology/Oncology

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Botryoid growth pattern (BGP) is a polypoid mass growing into the renal pelvis, rarely seen in bilateral Wilms tumors where it represents a surgical challenge. We report our experience of nephron sparing surgery in 3 patients with BGP in bilateral Wilms tumor. Surgical en bloc removal was performed after calyx opening with no complications. The histology of the BGP was Intralobar Nephrogenic Rest in all cases while all Wilms tumors were of intermediate risk. One patient early recurred. At a follow-up of 9 months, 22 and 23 years, all patients were alive with a moderate renal insufficiency and hypertension.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Nephron Sparing Surgery in Bilateral Wilms Tumors With Botryoid Growth Pattern

Mrad¹,

Audry²,

Tabone

et al. 2021

Journal of Pediatric Hematology/Oncology

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“…Such examples include 'fetal rhabdomyomatous WT', 6 'botryoid WT', and 'teratoid WT'-however, these 'entities' do not exist in either of the two major classifications (SIOP and COG), 1,7 and these features are of no prognostic significance, so their usage is not recommended. 8,9 H…”

Section: Viable Tumour Componentsmentioning

confidence: 99%

Dataset for the reporting of nephrectomy specimens for Wilms' tumour treated with preoperative chemotherapy: recommendations from the International Society of Paediatric Oncology Renal Tumour Study Group

et al. 2021

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Datasets for histopathological reporting of many cancer types are developed by the International Collaboration on Cancer Reporting (ICCR), and are used in order to ensure standardised and uniformly accepted reporting as one of the essential requirements for comparison across patient populations in evaluating and validating pathological prognostic and predictive factors. Wilms' tumours are rare, and international reporting guidelines have not yet been published by the ICCR. The assessment of Wilms' tumours differs according to the treatment approach. The Children's Oncology Group, whose approach is followed mainly in North America, advocates primary surgery, and the International Society of Paediatric Oncology Renal Tumour Study Group (SIOP-RTSG), whose approach is followed in most countries around the world, uses preoperative chemotherapy as a first step, resulting in different subclassifications, staging criteria, and histopathological prognostic factors. This dataset is developed for the countries and institutions following the SIOP-RTSG approach, and it contains core (required) and non-core (recommended) elements, based on the results of the previous SIOP-RTSG studies, which are incorporated in the latest SIOP-RTSG UMBRELLA 2016 Study protocol. The core elements include clinical information, additional specimen submitted, macroscopic tumour site and appearance, tumour focality, tumour dimensions, macroscopic extent of invasion, block identification key, histological tumour type, histological tumour grade and risk group assessment, microscopic extent of invasion, lymphovascular invasion, resection margin status, regional lymph node status, histologically confirmed distant metastases, and pathological staging (SIOP staging system). The dataset should improve communication for patient care and prognostic determination of the old and new histopathological features.

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Pathology

Tanwar

2022

Wilms’ Tumor

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Botryoid Wilms tumor: a non-existent “entity” causing diagnostic and staging difficulties

Cited by 14 publications

References 35 publications

Nephron Sparing Surgery in Bilateral Wilms Tumors With Botryoid Growth Pattern

Nephron Sparing Surgery in Bilateral Wilms Tumors With Botryoid Growth Pattern

Dataset for the reporting of nephrectomy specimens for Wilms' tumour treated with preoperative chemotherapy: recommendations from the International Society of Paediatric Oncology Renal Tumour Study Group

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