Bottlebrush dendritic endings and large dendritic fields: Motion-detecting neurons in the tectofugal pathway

Luksch, Harald; Cox, Kevin; Karten, Harvey J.

doi:10.1002/(sici)1096-9861(19980706)396:3<399::aid-cne9>3.0.co;2-y

Cited by 135 publications

(183 citation statements)

References 49 publications

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“…The tectofugal pathway originates in large neurons known as tectal ganglion cells (TGCs) residing in tectal layer 13 (Karten et al, 1997). These cells possess large dendritic arbors and have been shown to have large visual receptive fields with high sensitivity to moving visual stimuli (Luksch et al, 1998). Interestingly, a single site in nRt receives inputs from TGCs that are evenly distributed throughout the OT (Marín et al, 2003).…”

Section: The Avian Tectofugal Pathwaymentioning

confidence: 99%

“…11) suggests that the broad tuning of the single site in the E is a result of space-specific inputs converging from a wide area of the OT. Thus, the results presented here provide physiological evidence in favor of spatial information convergence, as suggested by the anatomical organization (Karten et al, 1997;Luksch et al, 1998;Marín et al, 2003).…”

Section: The Avian Tectofugal Pathwaymentioning

confidence: 99%

See 1 more Smart Citation

Auditory and Multisensory Responses in the Tectofugal Pathway of the Barn Owl

Reches¹,

Gutfreund²

2009

J. Neurosci.

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A common visual pathway in all amniotes is the tectofugal pathway connecting the optic tectum with the forebrain. The tectofugal pathway has been suggested to be involved in tasks such as orienting and attention, tasks that may benefit from integrating information across senses. Nevertheless, previous research has characterized the tectofugal pathway as strictly visual. Here we recorded from two stations along the tectofugal pathway of the barn owl: the thalamic nucleus rotundus (nRt) and the forebrain entopallium (E). We report that neurons in E and nRt respond to auditory stimuli as well as to visual stimuli. Visual tuning to the horizontal position of the stimulus and auditory tuning to the corresponding spatial cue (interaural time difference) were generally broad, covering a large portion of the contralateral space. Responses to spatiotemporally coinciding multisensory stimuli were mostly enhanced above the responses to the single modality stimuli, whereas spatially misaligned stimuli were not. Results from inactivation experiments suggest that the auditory responses in E are of tectal origin. These findings support the notion that the tectofugal pathway is involved in multisensory processing. In addition, the findings suggest that the ascending auditory information to the forebrain is not as bottlenecked through the auditory thalamus as previously thought.

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Section: The Avian Tectofugal Pathwaymentioning

confidence: 99%

Section: The Avian Tectofugal Pathwaymentioning

confidence: 99%

Auditory and Multisensory Responses in the Tectofugal Pathway of the Barn Owl

Reches¹,

Gutfreund²

2009

J. Neurosci.

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“…For instance, this approach is being used to trace projections from the inferior colliculus to the optic tectum in the barn owl (Luksch et al, 1996). In some preparations intracellular injections are possible in vivo or in whole-brains in vitro, yielding the complete description of dendritic arborisations and the axonal projection of individual neurones (Luksch et al, 1996(Luksch et al, , 1998.…”

Section: Intracellular Injectionmentioning

confidence: 99%

Current concepts in neuroanatomical tracing

Köbbert

Apps

Bechmann

et al. 2000

Progress in Neurobiology

380

336

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The development of new axonal tract tracing and cell labelling methods has revolutionised neurobiology in the last 30 years. The aim of this review is to consider some of the key methods of neuroanatomical tracing that are currently in use and have proved invaluable in charting the complex interconnections of the central nervous system. The review begins with a short overview of the most frequently used tracers, including enzymes, peptides, biocytin, latex beads, plant lectins and the everincreasing number of¯uorescent dyes. This is followed by a more detailed consideration of both well established and more recently introduced neuroanatomical tracing methods. Technical aspects of the application, uptake mechanisms, intracellular transport of tracers, and the problems of subsequent signal detection, are also discussed. The methods that are presented and discussed in detail include: (1) anterograde and retrograde neuroanatomical labelling with¯uorescent dyes in vivo, (2) labelling of post mortem tissue, (3) developmental studies, (4) transcellular tracing (phagocytosis-dependent staining of glial cells), (5) electrophysiological mapping combined with neuronal tract tracing, and (6) simultaneous detection of more than one axonal tracer. (7) Versatile protocols for three-colour labelling have been developed to study complex patterns of connections. It is envisaged that this review will be used to guide the readers in their selection of the most appropriate techniques to apply to their own particular area of interest. 7

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“…Tectal ganglion cells (TGCs) in deeper layers pool this precise retinotopy and project to the thalamic nucleus rotundus ( Fig. 1 A, B) (Benowitz and Karten, 1976;Karten et al, 1997;Luksch et al, 1998;Hellmann and Gü ntü rkü n, 2001;Luksch et al, 2001;Marín et al, 2003), resulting in large receptive fields (RFs), which typically would contain several stimuli simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Attentional Capture? Synchronized Feedback Signals from the Isthmi Boost Retinal Signals to Higher Visual Areas

Marı́n

Durán²,

Morales³

et al. 2012

J. Neurosci.

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When a salient object in the visual field captures attention, the neural representation of that object is enhanced at the expense of competing stimuli. How neural activity evoked by a salient stimulus evolves to take precedence over the neural activity evoked by other stimuli is a matter of intensive investigation. Here, we describe in pigeons (Columba livia) how retinal inputs to the optic tectum (TeO, superior colliculus in mammals), triggered by moving stimuli, are selectively relayed on to the rotundus (Rt, caudal pulvinar) in the thalamus, and to its pallial target, the entopallium (E, extrastriate cortex). We show that two satellite nuclei of the TeO, the nucleus isthmi parvocelullaris (Ipc) and isthmi semilunaris (SLu), send synchronized feedback signals across tectal layers. Preventing the feedback from Ipc but not from SLu to a tectal location suppresses visual responses to moving stimuli from the corresponding region of visual space in all Rt subdivisions. In addition, the bursting feedback from the Ipc imprints a bursting rhythm on the visual signals, such that the visual responses of the Rt and the E acquire a bursting modulation significantly synchronized to the feedback from Ipc. As the Ipc feedback signals are selected by competitive interactions, the visual responses within the receptive fields in the Rt tend to synchronize with the tectal location receiving the "winning" feedback from Ipc. We propose that this selective transmission of afferent activity combined with the cross-regional synchronization of the areas involved represents a bottom-up mechanism by which salient stimuli capture attention.

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Bottlebrush dendritic endings and large dendritic fields: Motion-detecting neurons in the tectofugal pathway

Cited by 135 publications

References 49 publications

Auditory and Multisensory Responses in the Tectofugal Pathway of the Barn Owl

Auditory and Multisensory Responses in the Tectofugal Pathway of the Barn Owl

Current concepts in neuroanatomical tracing

Attentional Capture? Synchronized Feedback Signals from the Isthmi Boost Retinal Signals to Higher Visual Areas

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