Bottom-up PBPK modeling of phenytoin brain disposition in postpartum newborns after intrauterine dosing
Mo’tasem M. Alsmadi
Abstract:Objectives
The antiepileptic phenytoin has a narrow therapeutic window, nonlinear pharmacokinetics, and can cross the placenta causing apathy and jitteriness in postpartum newborns. Further, the sudden decay of phenytoin concentration can cause withdrawal seizures. This work aimed to assess the brain toxic exposure to phenytoin in newborns after transplacental transfer using neonatal saliva-brain correlations.
Methods
The phe… Show more
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