A meteoric expansion in esthetic medicine followed the introduction of nonsurgical cosmetic neuromodulators and fillers in the early 2000s, which has been recently declining. The initial inertia has likely been tempered by the cosmetically interested patient's fear of appearing unnatural. Defining a natural outcome is a mission essential to the advancement of esthetic medicine; however, achieving a natural result following cosmetic intervention is a misnomer and a logically flawed endeavor that cannot exist. The ever elusive "natural" that is loudly desired by the populous, and ardently pursued by both industry and physicians, can only be an interpreted deduction. To better define a natural outcome, a novel model based on the theory of relativity is suggested. Attractiveness consists of a 3-dimensional area defined by beauty, genuineness, and self-esteem. When all three variables are at a maximum, a desirable attractive appearance is achieved that can be interpreted as "natural." Similar to the time-space dilemma, attractiveness is relative, dynamic, and highly dependent on the position of the projector and the interpreter. The 3D cube of attractiveness is therefore contained within a 4th dimension that takes into account the perspective of the judger. It is hoped that by realizing a new theory of what defines a natural outcome, esthetic medicine will be prepared to meet the needs of future generations.