Botulinum Toxin A for Treatment of Contact Granuloma

Yılmaz, Taner; Kayahan, Bahar; Günaydın, Rıza Önder; Kuşçu, Oğuz; Sözen, Tevfik

doi:10.1016/j.jvoice.2015.07.015

Cited by 22 publications

(17 citation statements)

References 14 publications

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“…In our study, 61 patients were recruited and completed at least a 48-week follow-up in the past 5 years. A distribution of middle age, distinct male predominance, and unilateral occurrence for such lesions in this study, which substantiates previous studies [5,6,12]. Tobacco, alcohol, voice abuse, and LPR remain the principal etiological factors for laryngeal contact granuloma [1,4]; this was the theoretical basis of the specific intervention for patients in the group receiving conservative treatment in our study.…”

Section: Discussionsupporting

confidence: 91%

“…Although possible etiological factors for the formation of laryngeal contact granuloma have been proposed, much less is known about how these factors influence the efficacy of treatment. To our knowledge, apart from being mentioned in the studies by Yilmaz et al [5] and Lee et al [6], the size of the granuloma, an important visual indicator, has received scant attention in its association with treatment outcome.…”

Section: Introductionmentioning

confidence: 98%

“…Intubation trauma was previously regarded as an important etiological factor; however, the formation and progression of intubation granuloma and contact granuloma are different. The former has a high rate of spontaneous resolution and should be deemed as a disparate disease entity [3,5,6]. Although possible etiological factors for the formation of laryngeal contact granuloma have been proposed, much less is known about how these factors influence the efficacy of treatment.…”

Section: Introductionmentioning

confidence: 99%

“…However, there is still no consensus on the treatment of laryngeal contact granuloma. Recently, several studies reported that botulinum toxin A injection was effective [5,7], but the dosages and injection sites were based on a laryngologist's experience without objective evidence. The commonly used dosage may be insufficient for some individuals, to ensure a complete response.…”

Section: Introductionmentioning

confidence: 99%

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Conservative Treatment versus Surgery for Laryngeal Contact Granuloma: A Prospective Study

Chen

Yang

et al. 2018

ORL

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Aims: To confirm the efficacy of conservative treatment for laryngeal contact granuloma and identify factors influencing treatment outcome. Methods: In this prospective study, patients with laryngeal contact granuloma were divided into a group receiving conservative treatment and a group undergoing surgery. Efficacy was assessed by analyzing the complete response after a 48-week follow-up. The association of treatment outcome with clinical factors was then evaluated. Results: In total, 61 patients, 43 in the group receiving conservative treatment and 18 in the group undergoing surgery, were analyzed, and the complete response rate was 72.1% and 38.9%, respectively. Both univariate analysis and multivariate analysis revealed that treatment modality (p₁ = 0.015, p₂ = 0.043), voice abuse (p₁ = 0.010, p₂ = 0.010), and the size of the granuloma (p₁ = 0.031, p₂ = 0.020) were significantly associated with the complete response of laryngeal contact granuloma. Kaplan-Meier curves showed that alcohol consumption (p = 0.031), voice abuse (p < 0.001), and granuloma size (p = 0.025) were significantly related to the complete response of conservative treatment. Conclusions: This prospective study strengthens the argument for conservative treatment (instead of surgery) as the first choice for laryngeal contact granuloma. The results also suggest that voice abuse, alcohol consumption, and the size of the granuloma may predict treatment outcome.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Conservative Treatment versus Surgery for Laryngeal Contact Granuloma: A Prospective Study

Chen

Yang

et al. 2018

ORL

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“…После удаления гранулемы в условиях прямой микрола-рингоскопии проводились инъекции ботулотоксина типа А в область щиточерпаловидных и латеральной перстне-черпаловидной мышцы. Только у 3 пациентов наблюда-лись рецидивы гранулем, в связи с чем проводились дополнительные инъекции ботулотоксина амбулаторно, а одному больному потребовалась повторная госпитализа-ция для реоперации [23,24].…”

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Treatment Experience of Patients With Laryngeal Granuloma Using High-Energy Surgical Equipment Ent

2017

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Гранулемы в зоне голосового отростка черпаловидного хряща (контактные) развиваются вследствие микротравмы, хро-нического кашля, гастроэзофагеального рефлюкса, перенапряжения голоса и психосоматических особенностей. В статье приведены данные обзора литературы по проблеме лечения гранулем гортани: хирургическое лечение показано при неэффективности консервативного лечения, а также при наличии образований, стенозирующих просвет гортани и требу-ющих морфологической верификации. В Клинике болезней уха, горла и носа Первого МГМУ им. И.М. Сеченова с 2014 по 2017 г. наблюдалось 8 пациентов: одна пациентка с постинтубационными гранулемами успешно прооперирована, реци-дива нет в течение 6 месяцев. Семь пациентов проходят лечение по поводу гастроэзофагеальной рефлюксной болезни, на фоне чего в одном случае отмечен полный регресс гранулемы; пяти больным проведено хирургическое удаление грану-лемы, из них у трех не было рецидива, а у двух отмечено повторное появление гранулем спустя 6 месяцев, по поводу чего они реоперированы. Интраоперационное применение радиоволнового аппарата при удалении гранулемы с последующей коагуляцией места ее прикрепления очевидно уменьшает риск рецидива. bothsides granuloma underwent a surgical excision under general anesthesia, followed up for 6 months and had no recurrence. 7 patients (6 males and 1 female) were treated with proton pump inhibitors due to they had gastroesophageal reflux disease. In 1 case contact granuloma reduced after 3 month conservative therapy without recurrence. One patient was non compliant. In 5 others microsurgical treatment performed. 2 of them had recurrent granuloma after 6 months and underwent repeated microsurgical excision using radiofrequency ablation. According the world and our own experience high-energy surgical equipment is recommended to be used in recurrent laryngeal granuloma to reduce it's recurrence rate.

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In‐office procedures for the treatment of benign vocal fold lesions in the awake patient: A contemporary review

et al. 2018

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Objectives To review available information regarding in‐office procedures for benign vocal fold lesions (BVFL). Methods PubMed term search on office/awake laryngeal procedures for any of the following specific lesions: Reinke's edema (RE), polyps, nodules, varices, vocal process granuloma, and vocal fold (VF) scar. Results In‐office ablative and nonablative laser procedures have been described for BVFL, including RE, polyps, varices, and granuloma. Fiber‐based lasers used include potassium titanyl phosphate, pulsed dye laser, and more recently CO2. In‐office intralesional steroid injection (ISI) for BVFL targets the inflammatory process involved with the lesion and may induce regression of polyps, nodules, RE, and granuloma. Botulinum toxin‐induced “voice rest” has been described as adjunctive treatment for refractory VF nodules or vocal process granuloma. Most in‐office techniques for treating BVFL rely on induction of lesion regression rather than complete lesion removal, as in conventional operative microsurgery. When treating VF scarring, in‐office procedures aim to alter the wound‐healing process; ISI targets the inflammatory phase and angiolytic lasers target the proliferative phase. Conclusion In‐office procedures for BVFL apply new technology that can potentially lower risk and cost. Although numerous case series have shown the potential of these procedures, data that thoroughly compares outcomes with those of microlaryngoscopic techniques is needed. Laryngoscope, 129:2131–2138, 2019

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Botulinum Toxin A for Treatment of Contact Granuloma

Cited by 22 publications

References 14 publications

Conservative Treatment versus Surgery for Laryngeal Contact Granuloma: A Prospective Study

Conservative Treatment versus Surgery for Laryngeal Contact Granuloma: A Prospective Study

Treatment Experience of Patients With Laryngeal Granuloma Using High-Energy Surgical Equipment Ent

In‐office procedures for the treatment of benign vocal fold lesions in the awake patient: A contemporary review

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