Botulinum toxin as a therapeutic agent to prevent relapse in deep bite patients

Mücke, Thomas; Löffel, Anja; Kanatas, Anastasios; Karnezi, Sandy; Rana, Majeed; Fichter, Andreas M.; Haarmann, Stephan; Wolff, Klaus‐Dietrich; Loeffelbein, Denys J.

doi:10.1016/j.jcms.2016.01.021

Cited by 18 publications

(35 citation statements)

References 26 publications

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“…Twenty‐eight articles were excluded based on the full text for the following reasons: surgery other than BSSO advancement (n = 14); studies in which muscle activity/traction was not investigated (n = 7); case reports with a sample of five cases or fewer, article reviews, meta‐analyses, letters, congress abstracts or commentaries (n = 4), full text unavailable (n = 2), and results presented in other included articles (n = 1). The remaining 10 articles were included in the qualitative synthesis 22‐31 …”

Section: Resultsmentioning

confidence: 99%

“…A total of 211 subjects from all 11 studies were diagnosed with Angle class II malocclusion. In one study on 32 subjects, class II malocclusion was further specified to a class II division 2 22 . In two of the 11 studies, class III subjects (n = 32) were included 24,26 .…”

Section: Resultsmentioning

confidence: 99%

“…However, the advancement measured at menton was 10.8 mm and 4.8 mm, respectively. Statistical analysis showed no significant difference in SR between the two groups after 10 months of follow-up.A third study, published by Mücke et al22 in 2016, introduced a new approach to alter muscular traction after BSSO. Thirty-two subjects diagnosed with a class II division II malocclusion and a deep bite were included in this prospective study.…”

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confidence: 99%

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The role of muscular traction in the occurrence of skeletal relapse after advancement bilateral sagittal split osteotomy (BSSO): A systematic review

Bempt

Vinayahalingam

Han

et al. 2021

Orthod Craniofacial Res

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The aim of this systematic review was (i) to determine the role of muscular traction in the occurrence of skeletal relapse after advancement BSSO and (ii) to investigate the effect of advancement BSSO on the perimandibular muscles. This systematic review reports in accordance with the recommendations proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Electronic database searches were performed in the databases MEDLINE, Embase and Cochrane Library. Inclusion criteria were as follows: assessment of relapse after advancement BSSO; assessment of morphological and functional change of the muscles after advancement BSSO; and clinical studies on human subjects. Exclusion criteria were as follows: surgery other than advancement BSSO; studies in which muscle activity/traction was not investigated; and case reports with a sample of five cases or fewer, review articles, meta-analyses, letters, congress abstracts or commentaries.Of the initial 1006 unique articles, 11 studies were finally included. In four studies, an intervention involving the musculature was performed with subsequent assessment of skeletal relapse. The changes in the morphological and functional properties of the muscles after BSSO were studied in seven studies. The findings of this review demonstrate that the perimandibular musculature plays a role in skeletal relapse after advancement BSSO and may serve as a target for preventive strategies to reduce this complication. However, further research is necessary to (i) develop a better understanding of the role of each muscle group, (ii) to develop new therapeutic strategies and (iii) to define criteria that allow identification of patients at risk.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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The role of muscular traction in the occurrence of skeletal relapse after advancement bilateral sagittal split osteotomy (BSSO): A systematic review

Bempt

Vinayahalingam

Han

et al. 2021

Orthod Craniofacial Res

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“…Recently, BTX application has been tried to prevent post-operative relapse after orthognathic surgery. Post-operative relapse has been reported after orthognathic surgery [ 60 ]. The main reason for post-operative relapse is the memory of masticatory muscles in their preoperative position [ 61 ].…”

Section: Clinical Application Of Btxmentioning

confidence: 99%

“…There has been comparative study on this issue. BTX has been given to the myohyoid muscle to reduce tension after surgery [ 60 ]. When compared to untreated control, the BTX application group has shown significantly higher positional stability.…”

Section: Clinical Application Of Btxmentioning

confidence: 99%

Correction of Malocclusion by Botulinum Neurotoxin Injection into Masticatory Muscles

Seok

Kim

2018

Toxins

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Botulinum toxin (BTX) is a neurotoxin, and its injection in masticatory muscles induces muscle weakness and paralysis. This paralytic effect of BTX induces growth retardation of the maxillofacial bones, changes in dental eruption and occlusion state, and facial asymmetry. Using masticatory muscle paralysis and its effect via BTX, BTX can be used for the correction of malocclusion after orthognathic surgery and mandible fracture. The paralysis of specific masticatory muscles by BTX injection reduces the tensional force to the mandible and prevents relapse and changes in dental occlusion. BTX injection in the anterior belly of digastric and mylohyoid muscle prevents the open-bite and deep bite of dental occlusion and contributes to mandible stability after orthognathic surgery. The effect of BTX injection in masticatory muscles for maxillofacial bone growth and dental occlusion is reviewed in this article. The clinical application of BTX is also discussed for the correction of dental malocclusion and suppression of post-operative relapse after mandibular surgery.Keywords: botulinum neurotoxin; masticatory system; maxillofacial bone; dental occlusion; orthognathic surgery Key contribution: BTX injection into masticatory muscles affects the maxillofacial bony growth and dental occlusion. In clinical practices, BTX injection has been used for reducing post-operative relapse after mandibular surgery.

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Future Perspectives of Botulinum Toxin Application in Dentistry

Etemad‐Moghadam

2020

Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine

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Botulinum toxin as a therapeutic agent to prevent relapse in deep bite patients

Cited by 18 publications

References 26 publications

The role of muscular traction in the occurrence of skeletal relapse after advancement bilateral sagittal split osteotomy (BSSO): A systematic review

The role of muscular traction in the occurrence of skeletal relapse after advancement bilateral sagittal split osteotomy (BSSO): A systematic review

Correction of Malocclusion by Botulinum Neurotoxin Injection into Masticatory Muscles

Future Perspectives of Botulinum Toxin Application in Dentistry

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