Botulinum Toxin Bladder Injection in the Treatment of Neurogenic Detrusor Overactivity and Idiopathic OAB

Marzi, Vincenzo Li; Frizzi, Jacopo; Bonifazi, Matteo; Popolo, Giulio Del

doi:10.1007/978-3-319-29191-8_13

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2019

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“…19 However, Marzi et al showed that side effects occurred in patients that received both low and high doses. 20 In our cases, the patients received 300 U onabotulinumtoxin A at each treatment, which is a relatively low dose compared to dosages often used in skeletal muscle. 1 The question of why the presentation in these two cases was focal and not systemic remains puzzling especially in case one where baseline motor strength was greater.…”

Section: Discussionmentioning

confidence: 94%

Focal arm weakness following intradetrusor botulinum toxin administration in spinal cord injury: Report of two cases

Goodrich

York

Shapiro³

et al. 2019

The Journal of Spinal Cord Medicine

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Context: Outpatient Spinal Cord Injury follow-up practice Findings: We present two cases of individuals with tetraplegia who experienced proximal arm weakness temporally related to the administration of intradetrusor onabotulinumtoxinA without other systemic effects. This arm weakness lasted approximately three months in both cases, whereas the effect of the toxin on the bladder lasted for over six months. In one of the cases, the pattern of proximal arm weakness after intravesicular botulinum toxin injection recurred after repeat injection. Conclusion: These cases represent a previously unreported phenomenon of proximal focal weakness associated with the use of intradetrusor chemodenervation. Possible mechanisms for these cases are discussed.

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Section: Discussionmentioning

confidence: 94%