Botulinum toxin combined with rehabilitation decrease corticomuscular coherence in stroke patients

Delcamp, Célia; Cormier, Camille; Chalard, Alexandre; Amarantini, David; Gasq, David

doi:10.1016/j.clinph.2021.12.019

Cited by 8 publications

(19 citation statements)

References 56 publications

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“…First, our results showed higher antagonist co-contraction for the paretic limb of stroke than for control subjects. This result fully agrees with the literature ( Gracies, 2005 ; Delcamp et al, 2022 ) and highlights the impairment of motor function present in the population of stroke subjects included in this study.…”

Section: Discussionsupporting

confidence: 93%

“…However, even though the non-paretic limb of the patients is not healthy, the ANCOVAs performed did not show any difference in IMC between the paretic and non-paretic limbs of the patients, which is in agreement with the work of Kitatani et al (2016) . Furthermore, work performed based on corticomuscular coherence analysis (between the brain and muscles) has also demonstrated the effect of stroke on the nature of the central drive involved in motor control for the paretic limb ( Krauth et al, 2019 ; Delcamp et al, 2022 ). Therefore, our results agree with these studies concerning the alteration of the motor control of stroke subjects’ paretic limbs.…”

Section: Discussionmentioning

confidence: 99%

“…As presented in Delcamp et al (2022) , subjects sat in front of a table, arms resting at 80° of shoulder flexion, 90° of shoulder internal rotation, elbow flexed at 90°, and the torso secured at the chair ( Figure 1 ). Following a sound signal, subjects were first asked to lift their arm from the table (up to 90° of shoulder flexion), followed by a maximal elbow extension movement at spontaneous speed, and finally to rest their arm now, extended back onto the table.…”

Section: Methodsmentioning

confidence: 99%

“…Kinematic continuous data were low-pass filtered at 6 Hz ( Cahouët et al, 2002 ; Delcamp et al, 2022 ). The onset and offset of each elbow extension movement were detected with a threshold of 0.01°/s applied to the elbow’s instantaneous angular velocity ( Chalard et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

“…Electromyographic continuous data were band-stop filtered at 49–51 Hz ( Krauth et al, 2019 ) to remove power line noise. As was done in Fauvet et al (2019 , 2021) , Glories et al (2021) , and Delcamp et al (2022) , the EMG signal was then 3-100 Hz band-pass filtered to keep the denoised part of the EMG signal energy that is necessary for reliable quantification of intermuscular coherence in the frequency band of interest in the present study. All the filters were fourth-order, zero-lag Butterworth types.…”

Section: Methodsmentioning

confidence: 99%

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Changes in intermuscular connectivity during active elbow extension reveal a functional simplification of motor control after stroke

et al. 2022

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BackgroundStroke alters muscle co-activation and notably leads to exaggerated antagonist co-contraction responsible for impaired motor function. However, the mechanisms underlying this exaggerated antagonist co-contraction remain unclear. To fill this gap, the analysis of oscillatory synchronicity in electromyographic signals from synergistic muscles, also called intermuscular coherence, was a relevant tool.ObjectiveThis study compares functional intermuscular connectivity between muscle pairs of the paretic and non-paretic upper limbs of stroke subjects and the dominant limb of control subjects, concomitantly between two muscle pairs with a different functional role, through an intermuscular coherence analysis.MethodsTwenty-four chronic stroke subjects and twenty-four healthy control subjects were included. Subjects performed twenty elbow extensions while kinematic data and electromyographic activity of both flexor and extensor elbow muscles were recorded. Intermuscular coherence was analyzed in the beta frequency band compared to the assessment of antagonist co-contraction.ResultsIntermuscular coherence was higher in the stroke subjects’ paretic limbs compared to control subjects. For stroke subjects, the intermuscular coherence of the antagonist-antagonist muscle pair (biceps brachii—brachioradialis) was higher than that of the agonist-antagonist muscle pair (triceps brachii—brachioradialis). For the paretic limb, intermuscular coherence of the antagonist-antagonist muscle pair presented a negative relationship with antagonist co-contraction.ConclusionDifferences in intermuscular coherence between the paretic limbs of stroke subjects and control subjects suggest a higher common central drive during movement. Furthermore, results highlight the association between stroke-related alteration of intermuscular functional connectivity and the alteration of motor function.

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Section: Discussionsupporting

confidence: 93%