Botulinum Toxin for Central Neuropathic Pain

Park, Jihye; Chung, Moonkyung

doi:10.3390/toxins10060224

Cited by 64 publications

(42 citation statements)

References 86 publications

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“…In addition, it was verified that BTX-A could repair the spinal cord injury induced by EMS via reducing apoptosis-related protein expression and increasing the outgrowth of spinal cord nerve cells. This conclusion is consistent with previous research that reported that BTX-A could repair the pain caused by inflammation and neuropathology ( 31 ) and increase the growth of spinal cord axons ( 32 ). Then, the possible mechanism of spinal cord nerve injury repair underlying the analgesic effect was investigating.…”

Section: Discussionsupporting

confidence: 93%

Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism

Tian

Cheng

et al. 2020

Mol Med Rep

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endometriosis (eMS) is a common disease in women aged 25-45 years, and pain is the main clinical symptom. The primary clinical treatment is surgical excision and drug therapy targeting the ectopic lesions, but these have not been very effective. Botulinum neurotoxin serotype a (BTX-a) has been reported to be useful in the treatment of pain in a variety of diseases. Based on this, the aim of the present study was to explore the therapeutic effect and mechanism of BTX-a on eMS. a model of nerve injury induced by oxygen glucose deprivation (oGd) was constructed in Pc12 cells and eMS mice. Model cells and mice were treated with different concentrations of BTX-a to observe the changes in pain behavior, to detect cell viability and the secretion of norepinephrine (ne) and methionine enkephalin (M-eK) in cells and the spinal cord, and to evaluate the expression of apoptosis-related molecules in spinal cord nerves. The results revealed that BTX-A significantly reduced the amount of writhing in model mice, enhanced the activity of Pc12 oGd cells, increased the secretion of ne and M-eK in model cells and the spinal cord of mice, and decreased the apoptosis of neural cells in the spinal cord of the model mice. Therefore, it was hypothesized that BTX-a may alleviate the pain induced by eMS by increasing the secretion of analgesic substances and promoting the repair of nerve injury. The present study provided a theoretical basis for the treatment of pain induced by eMS.

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Section: Discussionsupporting

confidence: 93%

Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism

Tian

Cheng

et al. 2020

Mol Med Rep

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“…Dramatic anti-hyperalgesia effects in uninjected contralateral hind paws of the rats were found in this study, which cannot be explained by the peripheral mechanism of BTX-A. These results suggested that BTX-A might have a central effect via the retrograde axonal transport system, which is also presumed to be the mechanism by which BTX-A acts to induce central neuropathic pain [83].…”

Section: Btx Effects In Central Nervous Systemsupporting

confidence: 52%

Effect of Botulinum Toxin A on Bladder Pain—Molecular Evidence and Animal Studies

Yeh

Chen

et al. 2020

Toxins

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Botulinum toxin A (BTX-A) is a powerful neurotoxin with long-lasting activity that blocks muscle contractions. In addition to effects on neuromuscular junctions, BTX-A also plays a role in sensory feedback loops, suggesting the potentiality for pain relief. Although the only approved indications for BTX-A in the bladder are neurogenic detrusor overactivity and refractory overactive bladder, BTX-A injections to treat bladder pain refractory to conventional therapies are also recommended. The mechanism of BTX-A activity in bladder pain is complex, with several hypotheses proposed in recent studies. Here we comprehensively reviewed properties of BTX-A in peripheral afferent and efferent nerves, the inhibition of nociceptive neurotransmitter release, the reduction of stretch-related visceral pain, and its anti-inflammatory effects on the bladder urothelium. Studies have also revealed possible effects of BTX-A in the human brain. However, further basic and clinical studies are warranted to provide solid evidence-based support in using BTX-A to treat bladder pain.

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“…18,19,34,[37][38][39] The effect of BTX-A may also be less evident in patients with no preservation of nociceptive input and structural or functional abnormalities of any one of the different components involved in the BTX-A mechanism of action. We could not identify any predictive factor among either the clinical parameters related to the diabetic neuropathy or the characteristics of selfreported pain severity, CSS, or CTF.…”

Section: Discussionmentioning

confidence: 99%