Botulinum toxin for the treatment of bruxism

Tınastepe, Neslihan; Küçük, Burcu Bal; Oral, Koray

doi:10.1080/08869634.2015.1097296

Cited by 20 publications

(27 citation statements)

References 65 publications

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“…It is beyond the scope of this review to describe the various studies, most of which are relatively small and open-label trials. BoNT has been reported to be safe and effective in the treatment of oromandibular dystonia, including bruxism [33][34][35][36] and jaw-opening dystonia 37 ; tremors, including essential tremor, parkinsonian rest tremors, dystonic tremors, task-specific tremors, and cerebellar tremors [38][39][40][41][42] ; tics 38 ; and various aspects of parkinsonism 43 besides tremor, including sialorrhea, 44,45 anterocollis/camptocormia, 46 overactive bladder, 47,48 pain, 49 depression, 50 and many other movement disorders or related conditions. 51 Spasticity is another form of movement disorder in which BoNT has been increasingly used.…”

Section: Clinical Use Of Bontmentioning

confidence: 99%

Botulinum toxin: State of the art

2017

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Botulinun neurotoxin (BoNT) has emerged as one of the most multipurpose therapeutic agents in modern medicine with more clinical applications than any other drug currently on the market. Initially developed in the treatment of strabismus and neurologic movement disorders, the use of botulinun neurotoxin has been expanding during the past 3 decades to include the treatment of a variety of ophthalmologic, gastrointestinal, urologic, orthopedic, dermatologic, dental, secretory, painful, cosmetic, and other conditions. In addition to onabotulinumtoxinA (Botox), abobotulinumtoxinA (Dysport), incobotulinumtoxinA (Xeomin), and RimabotulinumtoxinB (Myobloc or NeuroBloc) there are other novel botulinun neurotoxin products currently in development. With a better understanding of the cellular mechanisms of botulinun neurotoxin and advances in biotechnology, future botulinun neurotoxin products will likely be even more effective and customized to the specific indication and tailored to the needs of the patients. © 2017 International Parkinson and Movement Disorder Society.

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Section: Clinical Use Of Bontmentioning

confidence: 99%

Botulinum toxin: State of the art

2017

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“…We could speculate that an excessive amount of saliva may enhance jaw-closing movements; therefore, a decrease in salivation may improve bruxism. However, a masticatory muscle relaxation due to BTX spreading from parotid glands can not be excluded [ 12 ]. Unfortunately, our study did not show a correlation between drooling production and respiratory performances, although we found a slight tendency of dyspnoea improvement after BTX treatment.…”

Section: Discussionmentioning

confidence: 99%

The Treatment of Hypersalivation in Rett Syndrome with Botulinum Toxin: Efficacy and Clinical Implications

et al. 2019

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Introduction Subjects with Rett syndrome (RS) develop invariably severe motor deterioration resulting in swallowing difficulties that may produce excessive drooling. Hypersalivation can cause discomfort due to hygienic problems and may complicate with oral and respiratory dysfunctions. The aim of this study is to evaluate the response to treatment with botulinum toxin (BTX) for hypersalivation and to identify possible benefits of saliva reduction on oral motor and respiratory disorders of patients with RS. Methods Five consecutive patients with RS and hypersalivation were treated with incobotulinumtoxin A injected in salivary glands with ultrasound guidance. Severity of excessive drooling was assessed with the Thomas-Stonell and Greenberg Scale (TGSC) and the clinical impact of the treatment was evaluated using three selected items of RS Assessment Rating Scale (R.A.R.S.): eating habits, dyspnoea and bruxism. Scale rating was performed before BTX injection (T0), 4 (T1) and 12 (T2) weeks after. Results Scores of TGSC and R.A.R.S. (for eating and bruxism) were reduced significantly after therapy at T1. Conclusions BTX treatment for sialorrhea in RS is effective in reducing saliva production and may also improve oral motor functions. Electronic supplementary material The online version of this article (10.1007/s40120-018-0125-9) contains supplementary material, which is available to authorized users.

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“…2,21,25 However, further study is needed to elucidate the mechanism and safety of BTX-A injections. 2,20,21 To directly prevent injury, intraoral devices can be used, including mouth guards, splints, lip bumpers, and combinations thereof. These prosthetics serve to suppress biting behavior and act as physical barriers against injury, providing better protection and control according to some clinicians.…”

Section: Discussionmentioning

confidence: 99%

A Novel Approach for the Management and Prevention of Self-Induced Masticatory Lingual Trauma in the Neurologically Injured Patient

Avashia

Bittar

Suresh

et al. 2018

Craniomaxillofacial Trauma & Reconstruction

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Self-induced masticatory trauma is an unfortunate complication of a variety of neurologic disorders, including epileptic seizures, cerebral palsy, mental retardation, psychiatric disease, and brain trauma, in addition to other described etiologies. While single or occasional occurrences of tongue biting are relatively benign, recurrent self-injury can pose major issues and predispose a patient to chronic, severe complications. To prevent the complications associated with ongoing trauma to the tongue, steps must be taken to protect individuals from chronic self-injurious behavior. Often, these interventions cause significant morbidity to the patient, such as elective removal of the dentition or complications in gaining access to the oral cavity/airway associated with maxillomandibular fixation. In the neurologically impaired patient, immobilization of the jaws is frequently associated with higher rates of agitation, aspiration, or development of complicating infections of the gingival tissues. We report a case of self-induced masticatory trauma managed with the fabrication of a custom-fabricated oral appliance. This treatment modality successfully prevents the recurrence or incidence of self-induced masticatory trauma to the tongue. The benefits of this modality are that it allows access to the oral cavity, prevents immobilization of the jaws, has minimal to no morbidity, and is completely reversible.

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Botulinum toxin for the treatment of bruxism

Abstract: Evidence-based research was limited on this topic. More randomized controlled studies are needed to confirm that botulinum toxin is safe and reliable for routine clinical use in bruxism.

Cited by 20 publications

References 65 publications

Botulinum toxin: State of the art

Botulinum toxin: State of the art

The Treatment of Hypersalivation in Rett Syndrome with Botulinum Toxin: Efficacy and Clinical Implications

A Novel Approach for the Management and Prevention of Self-Induced Masticatory Lingual Trauma in the Neurologically Injured Patient

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