Botulinum toxin injections for adults with overactive bladder syndrome

Duthie, James B; Vincent, Michael S.; Herbison, Peter; Wilson, David Iain; Wilson, Don

doi:10.1002/14651858.cd005493.pub3

Cited by 155 publications

(72 citation statements)

References 40 publications

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“…The treatment requires the use of a cystoscope with direct injection of botulinum toxin into the detrusor muscle. Duthie et al [30] in a recent review evaluated 19 studies on botulinum toxin injections for adults with OABS and their conclusions were that intravesical botulinum toxin is an effective therapy for refractory OAB symptoms, but as yet little controlled trial data exist on benefits and safety compared with other interventions, or with placebo.…”

Section: Discussionmentioning

confidence: 99%

Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in Women with Overactive Bladder Syndrome: Results of a Randomized Controlled Crossover Study

Vecchioli-Scaldazza¹,

Morosetti²,

Berouz³

et al. 2013

Gynecol Obstet Invest

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Aims: This study compared the effectiveness of solifenacin succinate (SS) versus percutaneous tibial nerve stimulation (PTNS) in women with overactive bladder syndrome (OABS). Methods: A randomized controlled crossover study of 40 women with OABS was performed. Patients were randomized into two groups. In group A, patients received SS and then PTNS. In group B, patients underwent PTNS and then SS. Voiding diaries, quality of life surveys and patient perception of intensity of urgency questionnaire were performed before and after each treatment. The global impression of improvement questionnaire was performed at the end of the study. Results: A reduction in the number of daily micturitions, episodes of nocturia and urge incontinence were found with both SS and PTNS in all groups, but PTNS showed a greater effectiveness than SS. There was an increase in voided volume in all groups with both SS and PTNS, but patients treated with PTNS had a greater increase. PTNS showed greater effectiveness in patient perception of urgency and quality of life. Conclusion: This study demonstrates the effectiveness of SS and PTNS In women with overactive bladder symptoms. However, greater improvements were found with PTNS.

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Section: Discussionmentioning

confidence: 99%

Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in Women with Overactive Bladder Syndrome: Results of a Randomized Controlled Crossover Study

Vecchioli-Scaldazza¹,

Morosetti²,

Berouz³

et al. 2013

Gynecol Obstet Invest

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“…13 In 2011 these results were compiled in a Cochrane review, which evaluated 19 studies prior to February 2010 and showed that the use of onaBoNTA was superior to placebo in incontinence episodes and urinary frequency. Since this published Cochrane review, larger studies have replicated the efficacy of onaBoNTA over placebo.…”

Section: Medication Related Problemsmentioning

confidence: 99%

“…12 For these patients the use of onabotulinumtoxinA (onaBoNTA) has been proven safe and effective. 13 OnaBoNTA was approved by the FDA for the treatment of OAB in January 2013. 14 OnaBoNTA is administered via intravesical injections into several locations of the detrusor, the muscle of the bladder, under local anesthesia with effects typically lasting for twelve weeks.…”

Section: Introductionmentioning

confidence: 99%

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Use of OnabotulinumtoxinA for Overactive Bladder with Concomitant Warfarin

Peters

Vouri²

2014

Consult Pharm

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Overactive bladder symptoms (OAB) can be treated with oral medications using a variety of antimuscarinic medications and more recently mirabegron, a beta-3 agonist. However, the use of these medications may be limited for patients due to adverse drug reactions, contraindications, and those who are refractory to oral medications. Recently, intravesical injections of onabotulinumtoxinA (onaBoNTA) have been proven to be safe and effective as an alternative to oral OAB medications. Although this procedure is typically thought to be outside the realm of a consultant pharmacist, there are incidences in which a pharmacist can make a substantial impact on patient care. The patient, a 71 year old female, presents to her urologist for evaluation to assess appropriateness of intravesical onaBoNTA injections. She has failed multiple oral medications for the treatment of her OAB with urge incontinence. The procedure is further complicated by the patient’s past medical history of atrial fibrillation, deep vein thrombosis, and pulmonary embolism which requires anticoagulation with warfarin therapy. This case demonstrates the use of onaBoNTA for OAB in a patient concomitantly receiving warfarin for atrial fibrillation, pulmonary embolism, and deep vein thrombosis. Specifically, it demonstrates discontinuation, bridge therapy, and reinitiation of warfarin on a patient undergoing intravesical injections of onaBoNTA for OAB along with a collaborative approach to care with a pharmacist and urologist.

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“…5 1. Intravesical botulinum toxin 6 appears to be an effective therapy for refractory OAB symptoms, but as yet little data exist on benefits and safety compared with other interventions, or with placebo. Further data are required on long-term outcomes, safety, and optimal dose of botulinum toxin for OAB.…”

Section: What Is the Place Of Anticholinergic Drugs?mentioning

confidence: 99%

Urinary Incontinence: Revisited

Malhotra¹,

Rawat²,

Garg³

2014

Journal of South Asian Federation of Obstetrics and Gynaecology

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Patients usually under-report symptoms of incontinence. Therefore, improved physician-patient communication is vital. Most urinary incontinence can be evaluated and treated after careful history and simple clinical assessment. Initial treatment, for both urge urinary incontinence and stress urinary incontinence, is lifestyle modification and pelvic floor muscle exercises.Urgency responds to bladder training and drug therapy with anticholinergic medication. Pharmacotherapy has a limited place in stress incontinence.

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Botulinum toxin injections for adults with overactive bladder syndrome

Cited by 155 publications

References 40 publications

Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in Women with Overactive Bladder Syndrome: Results of a Randomized Controlled Crossover Study

Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in Women with Overactive Bladder Syndrome: Results of a Randomized Controlled Crossover Study

Use of OnabotulinumtoxinA for Overactive Bladder with Concomitant Warfarin

Urinary Incontinence: Revisited

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