Botulinum Toxin Injections Into the Lateral Cricoarytenoid Muscles for Vocal Process Granuloma

Pham, Quang; Campbell, Ross; Mattioni, Jillian; Sataloff, Robert T.

doi:10.1016/j.jvoice.2017.06.006

Cited by 20 publications

(16 citation statements)

References 10 publications

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“…described significant regression in the size of two vocal process granuloma lesions following office-based injection of botulinum toxin within the lateral cricoarytenoid muscle, thus alluding to the safety and effectiveness of this procedure. 17…”

Section: Discussionmentioning

confidence: 99%

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Interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma

Khalifee

Jaffal

et al. 2019

J. Laryngol. Otol.

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ObjectivesTo report on the efficacy and adverse effects of interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma.MethodsA retrospective chart review was conducted of eight patients with vocal process granuloma resistant to anti-reflux therapy who underwent interarytenoid botulinum toxin A injection. The mean dosage of botulinum toxin A injected was 6.56 U.ResultsFifty per cent of patients had complete regression of the lesion and 50 per cent had partial regression. The main side effects were breathiness (n = 4), voice breaks (n = 1) and aspiration (n = 1).ConclusionInterarytenoid botulinum toxin A injection for the treatment of vocal process granuloma is an effective mode of therapy, with transient vocal and swallowing side effects.

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Section: Discussionmentioning

confidence: 99%

“…in 1995, 12 numerous authors have corroborated its success. 13–17 Based on a nationwide multicentre review that included 590 cases of contact granulomas, botulinum toxin injection achieved the highest long-term complete or marked response rate (74 per cent), in comparison to surgical removal and other conservative measures. 6…”

Section: Introductionmentioning

confidence: 99%

Interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma

Khalifee

Jaffal

et al. 2019

J. Laryngol. Otol.

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“…28 Some physicians advocate for botulinum toxin (Botox, Allergan) injections to weaken the laryngeal musculature and thus prevent full glottic closure, which may decrease the amount of repeated trauma. 29 Finally, any known or suspected element of gastroesophageal reflux should be aggressively managed with proton pump inhibitors because exposure to acidic refluxate will only worsen the glottic irritation and inflammation, prolonging the time of healing. 28 Many experts believe that arytenoid dislocation is another potential complication of intubation.…”

Section: Dysphoniamentioning

confidence: 99%

Managing Otolaryngologic Complications in Cardiothoracic Surgery

Huston

Naunheim

2020

The Annals of Thoracic Surgery

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“…However, there is still no consensus on the treatment of laryngeal contact granuloma. Recently, several studies reported that botulinum toxin A injection was effective [5,7], but the dosages and injection sites were based on a laryngologist's experience without objective evidence. The commonly used dosage may be insufficient for some individuals, to ensure a complete response.…”

Section: Introductionmentioning

confidence: 99%

Conservative Treatment versus Surgery for Laryngeal Contact Granuloma: A Prospective Study

Chen

Yang

et al. 2018

ORL

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Aims: To confirm the efficacy of conservative treatment for laryngeal contact granuloma and identify factors influencing treatment outcome. Methods: In this prospective study, patients with laryngeal contact granuloma were divided into a group receiving conservative treatment and a group undergoing surgery. Efficacy was assessed by analyzing the complete response after a 48-week follow-up. The association of treatment outcome with clinical factors was then evaluated. Results: In total, 61 patients, 43 in the group receiving conservative treatment and 18 in the group undergoing surgery, were analyzed, and the complete response rate was 72.1% and 38.9%, respectively. Both univariate analysis and multivariate analysis revealed that treatment modality (p₁ = 0.015, p₂ = 0.043), voice abuse (p₁ = 0.010, p₂ = 0.010), and the size of the granuloma (p₁ = 0.031, p₂ = 0.020) were significantly associated with the complete response of laryngeal contact granuloma. Kaplan-Meier curves showed that alcohol consumption (p = 0.031), voice abuse (p < 0.001), and granuloma size (p = 0.025) were significantly related to the complete response of conservative treatment. Conclusions: This prospective study strengthens the argument for conservative treatment (instead of surgery) as the first choice for laryngeal contact granuloma. The results also suggest that voice abuse, alcohol consumption, and the size of the granuloma may predict treatment outcome.

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Botulinum Toxin Injections Into the Lateral Cricoarytenoid Muscles for Vocal Process Granuloma

Cited by 20 publications

References 10 publications

Interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma

Interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma

Managing Otolaryngologic Complications in Cardiothoracic Surgery

Conservative Treatment versus Surgery for Laryngeal Contact Granuloma: A Prospective Study

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