Botulinum Toxin Paves the Way for the Treatment of Functional Lower Urinary Tract Dysfunction

Kuo, Hann‐Chorng

doi:10.3390/toxins12060394

Cited by 3 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yu et al demonstrated that the level of malondialdehyde (MDA), a marker of oxidative stress which indicates the rate of lipid peroxidation, was considerably reduced in spinal cord injury-induced mice model treated with BoNT along with minocycline, indicating reduced oxidative stress [ 65 ]. Further, many studies have suggested the use of therapeutic BoNT-A in urinary bladder dysfunctions resulting from prostatic hyperplasia due to its positive effect in controlling oxidative stress [ 66 , 67 ]. Very recently, Yesudhas et al reported that BoNT improves the enzymatic activities of key antioxidants and provides neuroprotection in the brain of ageing experimental animals [ 11 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

et al. 2022

View full text Add to dashboard Cite

Background Botulinum toxin (BoNT) is a widely used therapeutic agent that blocks the excessive release of acetylcholine at the neuromuscular junction. Previously, repeated intracremasteric injections and slight overdose of BoNT have been reported to induce adverse effects in the testicular parameter of experimental rodents. However, a mild dose of BoNT is highly beneficial against skin ageing, neuromuscular deficits, overactive urinary bladder problems, testicular pain and erectile dysfunctions. Considering the facts, the possible therapeutic benefits of BoNT on the testis might be achieved at a very minimal dosage and via a distal route of action. Therefore, we revisited the effect of BoNT, but with a trace amount injected into the vastus lateralis of the thigh muscle, and analyzed histological parameters of the testis, levels of key antioxidants and sperm parameters in ageing experimental mice. Results Experimental animals injected with 1 U/kg bodyweight of BoNT showed enhanced spermatogenesis in association with increased activities of key antioxidants in the testis, leading to enhanced amount of the total sperm count and progressive motility. Conclusions This study signifies that a mild intramuscular dose of BoNT can be considered as a potent treatment strategy to manage and prevent male infertility.

show abstract

Section: Discussionmentioning

confidence: 99%

Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Several issues are difficult to treat using medication or surgery. Because Botox has an anti-inflammatory mechanism of action, LUTDs related to chronic inflammation might be treated with Botox injection at the target organ or afferent nerves to achieve a satisfactory result [ 148 ]. In patients with chronic SCI, AD is a challenge for urological management, and Botox injection might reduce AD severity and improve the quality of life of these patients.…”

Section: Potential Clinical Applications Of Botox On Recurrent Uti De...mentioning

confidence: 99%

Clinical Application of Botulinum Neurotoxin in Lower-Urinary-Tract Diseases and Dysfunctions: Where Are We Now and What More Can We Do?

Kuo

2022

Toxins

Self Cite

View full text Add to dashboard Cite

Botulinum toxin A (Botox) had been considered a promising drug that has an effect on functional disorders of the lower urinary tract. Because Botox exhibits anti-inflammatory and antispasmodic effects, Botox injection into the bladder can decrease detrusor contractility, reduce bladder hypersensitivity, and eliminate painful sensations. Injecting Botox into the bladder outlet can relax the hyperactivity of the bladder neck, and of the urethral smooth and striated muscles. Based on these therapeutic effects, Botox has been widely applied to treat lower-urinary-tract dysfunctions (LUTDs) such as overactive bladder and neurogenic detrusor overactivity. However, this treatment has not been licensed for use in other LUTDs such as interstitial cystitis, voiding dysfunction due to benign prostatic hyperplasia in men, and dysfunctional voiding in women. Botox has also not been approved for the treatment of children with overactive bladder and dysfunctional voiding; in patients with spinal cord injuries with detrusor sphincter dyssynergia and autonomic dysreflexia; or for poorly relaxed external sphincter in non-neurogenic patients. This article reviews the current knowledge regarding Botox treatment for LUTDs and discusses the potential clinical applications of Botox, as well as work that can be conducted in the future.

show abstract

Emerging molecular mechanisms and genetic targets for developing novel therapeutic strategies for treating bladder diseases

Zoqlam

Lazauskaite

Glickman³

et al. 2022

European Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Botulinum Toxin Paves the Way for the Treatment of Functional Lower Urinary Tract Dysfunction

Abstract: Botulinum toxin A (BoNT-A) is a potent protein that can selectively modulate neurotransmission from nerve endings, resulting in the blocking of neurotransmitter releases and causing muscular paralysis [...]

Cited by 3 publications

References 18 publications

Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

Clinical Application of Botulinum Neurotoxin in Lower-Urinary-Tract Diseases and Dysfunctions: Where Are We Now and What More Can We Do?

Emerging molecular mechanisms and genetic targets for developing novel therapeutic strategies for treating bladder diseases

Contact Info

Product

Resources

About